The effect of malignant disease on the metabolism of pteroylglutamic acid in man

Saleh, Adly M.; Pheasant, Anne E.; Blair, J. Anthony; Allan, Robert

doi:10.1042/bst0080566

Cited by 10 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is probably due to uptake of folate and formation of polyglutamates by a large tumour mass. Similar observations have been reported for human subjects suffering from malignancies (Saleh et al, 1980). Catabolism of folate was also decreased in the tumour-bearing rats.…”

Section: Effect Of a Tumoursupporting

confidence: 76%

See 1 more Smart Citation

Folate catabolism in tumour-bearing rats and rats treated with methotrexate

Saleh¹,

Pheasant²,

Blair³

1981

Br J Cancer

View full text Add to dashboard Cite

The metabolism of (2-14C) + (3',5',7,9-3H) folic acid was studied in normal rats, tumour-bearing rats and rats treated with methotrexate (MTX). The experiments were designed to investigate changes in the catabolism and folate. The breakdown of folate to scission products was again demonstrated to be a normal phenomenon. Catabolites excreted included p-acetamidobenzoate, p-acetamidobenzoyl-L-glutamate, 3H2O, urea and a number of pterins. The catabolic process was decreased in the presence of a tumour and increased by the administration of MTX. MTX also led to the excretion of 4 additional radioactive pterins not found in normal urine. The possible mechanisms of folate breakdown are discussed with reference to the point of action of MTX.

show abstract

Section: Effect Of a Tumoursupporting

confidence: 76%

“…Folate metabolism in vivo is known to be affected by the presence of a tumour; preliminary studies suggest that the catabolism of folate may be depressed Saleh et al, 1980). Methotrexate (MTX) is a folate antagonist which is used in cancer chemotherapy.…”

mentioning

confidence: 99%

Folate catabolism in tumour-bearing rats and rats treated with methotrexate

Saleh¹,

Pheasant²,

Blair³

1981

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Decreasing the dose of folic acid to I 0 mg or 0 5 mg has been shown to lead to lower recovery of radioactivity in urine, with a greater fall in excretion of folic acid than of the other metabolites (Saleh et al, 1980). In this study a dose about equal to the daily intake of folate was given (60 ,g) and the results confirmed the observations of Pheasant et al (1979).…”

Section: Discussionsupporting

confidence: 80%

“…Therefore the metabolism of a mixture of 14C-and 3H-labelled folic acid was studied in control patients and in patients with malignant disease in order to observe any metabolic variations which may have diagnostic or therapeutic applications. Preliminary results have been reported elsewhere (Saleh et al, 1980). 10-Formylfolate, an oxidized folate, is an important constituent of food folate (Butterworth et al, 1965;Santini et al, 1964).…”

mentioning

confidence: 99%

Folate metabolism in man: the effect of malignant disease

Saleh¹,

Pheasant²,

Blair³

et al. 1982

Br J Cancer

View full text Add to dashboard Cite

The metabolism of [2-14C]+[3', 5', 7, 9-3H] folic acid and [214C]+[3', 5', 7, 9-3H] 10-formylfolate was studied in hospital inpatients. Metabolites detected in the urine after folic acid feeding included the unchanged compound, other folates and a number of breakdown products, such as p-acetamidobenzoyl-L-glutamate and p-acetamidobenzoate. This confirms the existence of a folate catabolic pathway in man. Patients with malignant disease excreted less of the dose in urine, incorporated more into the reduced folate pool, and showed decreased catabolism of folate, when compared to controls. 10-Formylfolate was excreted largely unchanged, and appears not to be reduced by man. Also 10-formylfolate interfered with the reduction of folic acid given simultaneously.

show abstract

“…Recently, ras p-acetamidobenzoyl-L-glutamate (Figurel 20) has been identified in rat urine (Murphy et al, 1976;Connor et al, 1979), in guinea-pig urine (Choolun et al, 1980) and in human urine (Saleh et al, 1980), after oral doses of CoH] -folic acid, 10-formyl FA (Connor, 1979) or 5-MeTHF (Kennelly et al, 1979 b;Kennelly, 1980).…”

Section: Transfersmentioning

confidence: 99%