The effect of mangrove (Rhizophora apiculata) bark extract ethanol on histopathology pancreas of male white rats Sprague Dawley strain exposed to cigarette smoke

Abstract

Background: Cigarette smoke is free radical that causing some pathological conditions such as inflammation, proteolysis, and oxidative stress. In previous studies, mangrove (Rhizophora apiculata) bark extract showed the potential effect as an antioxidant. Mangrove and mangrove associates are abundant plants that grow throughout Indonesian shorelines that have high pharmaceutical and food values.Objective: The purpose of this study is to explore the potential of Rhizophora apiculata bark extract in protecting pancreas of male white rat (Rattus novergicus) Sprague Dawley strain exposed to cigarette smoke.Methods: This research was an experimental study using a posttest-only control group design. Mangrove bark was extracted by using the maceration method. Cigarette smoke exposure was performed using an electric cigarette. Liver inflammation is assessed histopathologically.Results: Significant results (p <0.05) were found between the control and cigarette groups as well as the cigarette and bark extract + control groups. The results were not significant (p> 0.05) between the control and the bark extract + cigarette.Conclusion : The administration of mangrove bark extract has a potential to protect the damage of pancreatic male white rats (Rattus norvegicus) Sprague Dawley strains exposed to cigarette smoke

Alpha‐Lipoic Acid Modulates the Oxidative and Inflammatory Responses Induced by Traditional and Novel Tobacco Products in Human Liver Epithelial Cells

“…In addition to the primary oxidant action, the constituents in the gas phase of cigarette smoke are able to enter the systemic circulation via the pulmonary circulation, and exacerbate systemic effects such as inflammation [36] . Since smoking is a source of free radical formation that causes crucial pathological conditions such as inflammation, [37] CSE and HTP‐induced inflammatory biomarkers in HepG2 cells were assessed in the present study. For this purpose, nitrite level as an important biochemical marker for acute injury and inflammation, pro‐inflammatory cytokine IL‐6 level, and a ligand‐activated transcription factor mediating inflammatory response and metabolism, [38] AhR level, were determined in HepG2 cells with or without α‐LA pre‐treatments.…”

Pengaruh Ekstrak Etanol Daun Rhizophora apiculata terhadap Kolesterol Total dan Trigliserida Rattus norvegicus Galur Sprague dawley yang Diinduksi Diet Tinggi Lemak

“…Pada tanaman bakau minyak juga banyak mengandung senyawa antioksidan pada bagian-bagian tumbuhannya (Berawi dan Marini, 2018). Pada penelitian yang lainnya, manfaat dari penggunaan ekstrak bakau memiliki efek antioksidan pada dosis 56,55mg/kgBB (Mustofa, et al, 2018;Mustofa dan Hanif, 2019;.…”