The effect of marital status on stage at diagnosis and survival in Saudis diagnosed with colorectal cancer: cancer registry analysis

Alyabsi, Mesnad; Ramadan, Majed; Algarni, Mohammed; Alshammari, Kanan; Jazieh, Abdul Rahman

doi:10.1038/s41598-021-88042-9

Cited by 20 publications

(15 citation statements)

References 44 publications

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“…Several clinical studies have shown that socio‐psychosocial factors are important prognostic factors in a variety of tumor types in both adults and adolescents, 21–24 and marital status is one of the most important socio‐psychosocial factors 25–27 . Recent studies have focused on marital status and cancer, and the results suggest that married patients have significantly better survival than unmarried patients 27–29 . However, to date, there have been few studies on the effect of marital status among patients with RPLs.…”

Section: Introductionmentioning

confidence: 99%

Effects of marital status on survival of retroperitoneal liposarcomas stratified by age and sex: A population‐based study

Zhang

et al. 2022

Cancer Medicine

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Background Previous studies have shown that marital status is associated with survival in patients with a variety of cancer types, including lung cancer, prostate cancer, and bladder cancer. However, to date, the impact of marital status on the survival of patients with retroperitoneal liposarcomas (RPLs) has not been established. Methods A total of 1211 eligible patients diagnosed with RPLs were identified in the Surveillance, Epidemiology, and End Results (SEER) database. The relationships between marital status and survival in patients with RPLs were assessed. Patients were stratified by age to determine whether an association exists between marital status and age. We also probed the association between marital status and survival in males and females. Results Our findings suggest that divorced, separated, or widowed patients have more advanced cancer stages, and more of these patients do not undergo surgery. Meanwhile, divorced, separated, or widowed patients have worse survival outcomes than married patients (overall survival (OS): HR = 1.66 (95% CI, 1.12, 2.46)); cancer‐specific survival (CSS): HR = 1.90 (95% CI, 1.13, 3.19)). OS does not differ between single patients and married patients (HR = 1.21 [95% CI, 0.81, 1.81]) or CSS (HR = 1.36 [95% CI, 0.80, 2.29]). In addition, these results demonstrate that being divorced, separated, or widowed can play a significant detrimental role in mortality in older and female patients. Conclusion Married patients have earlier disease stages at diagnosis and better survival outcomes than divorced, separated, or widowed patients with RPLs. In addition, this effect is especially pronounced in older people and females.

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Section: Introductionmentioning

confidence: 99%

Effects of marital status on survival of retroperitoneal liposarcomas stratified by age and sex: A population‐based study

Zhang

et al. 2022

Cancer Medicine

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“…For instance, women with BMI ≥ 23 at age 18 had a 63% higher risk of early-onset CRC compared to women with a BMI of 18.5-20.9 (10). Third, there is currently no population-based screening for CRC in Saudi Arabia, leading to delayed CRC detection, increased late-stage diagnosis, and poor survival across all age groups (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Trends in Colorectal Cancer Incidence Rates in Saudi Arabia (2001–2016) Using Saudi National Registry: Early- Versus Late-Onset Disease

2021

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Early-onset (<50 years old) colorectal cancer (CRC) has been increasing worldwide and is associated with poor outcomes. Over 85% of the Saudi population are <50 years old, which put them at heightened risk of early-onset CRC. No study assessed the trends in CRC incidence rates among the Saudis. The Joinpoint Regression software by the Surveillance, Epidemiology, and End Results (SEER) program was used to estimate the magnitude and direction of CRC incidence trends by age and gender. The annual percentage change (APC) and the average annual percentage change (AAPC) between 2001 and 2016 were computed. In a sensitivity analysis, we also assessed trends using various age groups. Between 2001 and 2016, the early-onset CRC incidence (per 105) increased from 1.32 (95% CI: 1.11, 1.54) to 2.02 (95% CI: 1.83, 2.22) with AAPC (2.6, 95% CI: -0.4, 5.7). At same period, the late-onset incidence increased from 3.54 (95% CI: 3.10, 3.97) to 9.14 (95% CI: 8.62, 9.66) with AAPC (6.1, 95% CI: 3.5, 8.8). Among early-onset CRC patients, age 40–49 has the highest rates and women in this age group has higher rate than men. Our national data showed a gradual increase in CRC incidence rates, which reflect the global concern of early-onset CRC. Further research is needed to understand the etiology of early-onset CRC. Primary health care providers must be alerted about the increasing rate of early-onset CRC. To reduce the future burden of the disease, initiating CRC screening before age 50 is warranted.

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“…Several epidemiologic cancer studies have found marital status to be an independent prognostic factor. Married patients were found to have a lower overall and cancer speci c mortality, compared to their non married counterparts [18][19][20][21][22][23][24][25][26][27]. This was mainly thought to be due to better social support among married patients.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology And Prognosis Factors Of Primary GI Melanoma In The Past Decade: Results From The SEER Database

Bangolo

Fwelo

Trivedi

et al. 2022

Preprint

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Background: Primary malignant melanomas of the Gastric mucosa are uncommon. Most cases of Gastrointestinal (GI) melanomas are secondary, arising from metastasis at distant sites. GI melanomas have been associated with dismal prognosis, owing to their identification at more advanced stages. The purpose of this study is to investigate the clinical characteristics, survival outcomes, and prognostic factors of patients with primary GI melanoma in the past decade. Methods: A total of 399 patients diagnosed with Primary GI melanoma, between 2008 and 2017, were ultimately enrolled in our study by retrieving the Surveillance, Epidemiology, and End Results (SEER) database. We analyzed demographics, clinical characteristics, and overall mortality (OM) as well as cancer-specific mortality (CSM) of primary GI melanoma. Variables with a p value < 0.1 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors, with a hazard ratio (HR) of greater than 1 representing adverse prognostic factors.Results: From a sample of 399 primary GI melanomas, male gender (56.4%), age range 60-79 years (52.88%), non-Hispanic whites (70.18%), as well as annual income of $75,000+ yearly (30.33%) were the most represented. Crude analysis revealed higher overall mortality (OM) in age group 80+ (HR = 4.042, 95% CI 1.732 - 9.433, p = 0.001), stomach location of the tumor (HR = 3.261, 95% CI 1.658 - 6.417, p = 0.001), distant metastases (HR = 2.967, 95% CI 2.22 - 3.965, p=0 ), Nonmetropolitan counties not adjacent to a metropolitan area ( HR= 2.211, 95 % CI 1.253-3.9, p=0.006 ), and chemotherapy ( HR= 1.417, 95% CI 1.078-1.863, p=0.012). Crude analysis for Cancer specific mortality (CSM) also revealed higher mortality in the same groups. Multivariate cox proportional hazard regression analyses only revealed higher OM in age group 80+ (HR = 5.653, 95% CI 2.212 - 14.445, p=0), stomach location of the tumor (HR = 2.821, 95% CI 1.265 - 6.292, p = 0.011), and distant metastases (HR= 4.491, 95% CI 3.115-6.476, p=0). Multivariate cox proportional hazard regression analyses of CSM also revealed higher mortality of the same groups.Conclusion: Primary GI melanoma is a rare entity. Only a few studies have been carried out in recent years to evaluate factors affecting the survival and mortality of primary GI melanoma. The paucity of data on primary GI melanoma governed the need of this study. In this population-based retrospective cohort study using the SEER database, we found that age at diagnosis, the primary site of the disease, and advanced disease at diagnosis were independent factors predicting poor prognosis. Furthermore, even surgical resection did not significantly impact the overall mortality or the cancer-specific mortality. This cohort paves the path for further prospective studies identifying individuals at an increased risk of primary GI melanomas, earlier and closer screenings in such individuals, and then evaluation of long-term prognosis in these patients as age and advanced disease were both independent risk factors predicting poor prognosis in our study.

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The effect of marital status on stage at diagnosis and survival in Saudis diagnosed with colorectal cancer: cancer registry analysis

Cited by 20 publications

References 44 publications

Effects of marital status on survival of retroperitoneal liposarcomas stratified by age and sex: A population‐based study

Effects of marital status on survival of retroperitoneal liposarcomas stratified by age and sex: A population‐based study

Trends in Colorectal Cancer Incidence Rates in Saudi Arabia (2001–2016) Using Saudi National Registry: Early- Versus Late-Onset Disease

Epidemiology And Prognosis Factors Of Primary GI Melanoma In The Past Decade: Results From The SEER Database

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