The Effect of Maximal and Submaximal Exercise Testing on NT-proBNP Levels in Patients with Systolic Heart Failure

Zdrenghea, Dumitru; Ilea, Maria; Zdrenghea, Mihnea; Sitar-Tăut, Adela; Pop, Dana

doi:10.2478/rrlm-2014-0008

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…In our study the median ejection fraction was of 45 %. There is evidence that heart failure with preserved ejection fraction is associated with an accelerated production and also an abnormal degradation of collagen [23]. ESC current guideline for the diagnosis and treatment of acute and chronic heart failure highlights that one out of six patients experiencing exertion symptoms of heart failure, who fits in the heart failure with preserved ejection fraction class remains undiagnosed [1].…”

Section: Discussionmentioning

confidence: 99%

The profile of cardiovascular risk factors in heart failure obese patients hospitalised in a rehabilitation romanian hospital

Dădârlat¹,

Sitar-Tăut²,

Zdrenghea³

et al. 2018

Balneo

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Introduction.Despite all advanced evidence-based therapeutic opportunities, heart failure remains a major public health burden, with a dramatically increasing in prevalence. Moreover, the diagnosis of chronic heart failure in obese patients brings unique challenges. So, the aim of this study was to identify the cardiovascular risk factors profile in heart failure obese patients, admitted in rehabilitation programs. Material and methods.This study enrolled 80 obese (body mass index ≥30 kg/m2) patients, 56.2% men with average age ranged of 69.75 ± 9.12 years who were hospitalized for decompensated heart failure in the Rehabilitation Hospital, Cardiology-Department, Cluj-Napoca, Romania. Baseline characteristics, clinical presentation, NT-proBNP values, echocardiographic parameters and in-hospital therapies were evaluated. The lot was divided into three groups: obese heart failure patients with reduced (<40%), preserved (≥50%), and midrange (40-49%) ejection fraction. Heart failure was defined according to 2016 ESC criteria. NT-pro-BNP values higher than 125 pg/ml were considered to be associated with heart failure development. Statistics were performed using SPSS 16.0 for Windows. Results.The mean age of the analyzed study population was 69.75 ± 9.12 years and 56.2% were men. The most frequent associated risk factor was smoking (45%), followed by diabetes mellitus (40%) and hypertension (25%). The mean ejection fraction value was 43.58±10.85% and the median value was 45%. The mean NT-pro-BNP registered levels were 2887.03±3157 pg/ml. An inverse relationship was found between NT-pro-BNP levels and plasma lipid fractions, total-cholesterol-r=-0.194, LDL-cholesterol-r=-0.0971, triglycerides-r=-0.155, HDL-cholesterol-r=-0.07. Also, NT-proBNP negatively correlated with left ventricular ejection fraction-r=-0.307, p=0.0086. In conclusion, obese heart failure patients presented particular characteristics, the most frequent observed cardiovascular risk factors were smoking, diabetes mellitus and arterial hypertension. Identifying the major comorbidities in this subgroup of patients is of major importance, especially for improving heart failure's prognosis and survival.

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Section: Discussionmentioning

confidence: 99%

The profile of cardiovascular risk factors in heart failure obese patients hospitalised in a rehabilitation romanian hospital

Dădârlat¹,

Sitar-Tăut²,

Zdrenghea³

et al. 2018

Balneo

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“…Based on the present results regarding the effects of statins on ChE activity following drug type and duration of therapy as well as on the results of other investigators (Darvesh et al, 2004;Cibickova et al, 2007;Roensch et al, 2007;Vukšić et al, 2019), caution should be practised in generalising this notion on all statins, which differ considerably in their pharmacokinetic, pharmacodynamics, and even neurotoxic profiles (Bocan, 2002;Butterfield et al, 2011;Zhang et al, 2018;Hirota et al, 2020). The statins vary greatly when pseudo and true ChE are considered for any activity modulation (Zdrenghea et al, 2002;Darvesh et al, 2004;Muačević-Katanec et al, 2005;Cibickova et al, 2007;Cibickova et al, 2009;Macan et al, 2015;Vukšić et al, 2019). Therefore, extensive preclinical studies are needed on different types of statins, considering their anti-ChE and potential neurotoxic effects.…”

Section: Discussionmentioning

confidence: 76%

“…Lovastatin and simvastatin inhibited plasma ChE activity, whereas mevastatin and pravastatin did not in patients on lipidlowering therapy (Darvesh et al, 2004). Moreover, patients on simvastatin did not suffer from changes in serum ChE (Zdrenghea et al, 2002;Muačević-Katanec et al, 2005). Based on these studies, current evidence suggests no single unified pharmacological effect of statins on blood or brain ChE activity, as the statins vary in their chemical and physical properties and pharmacological effects (Bocan, 2002;Zhang et al, 2018;Hirota et al, 2020;Fan et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Differential effects of statins on plasma and brain cholinesterase activities in chicks

Rashid,

Mohammad

2023

Neurosci Res Notes

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Statins used to treat dyslipidemia may differentially modulate cholinesterase (ChE) activity impacting neuronal function. This study examines the effects of three statins (atorvastatin, fluvastatin, and simvastatin) on plasma and brain ChE activities and cholesterol levels in a chick model of 7-14 days old. Chicks were dosed orally with single doses of each statin at 50, 100, and 200mg/kg or repeated doses at 100mg/kg/day for 14 consecutive days. Plasma and whole brain ChE activities were measured electrometrically, whereas cholesterol levels were measured using a commercial colourimetric kit. In vitro ChE inhibition by the statins was initiated at 37°C for 10 mins. Data were statistically analysed using analysis of variance followed by the least significant difference test. Atorvastatin and fluvastatin did not significantly affect plasma ChE activities 2 hours after the oral administration, whereas simvastatin at 100 and 200mg/kg significantly increased (28% and 16%, respectively) plasma ChE activity. Repeated oral doses of the statins did not significantly affect plasma ChE activity. However, only simvastatin significantly decreased whole brain ChE activity by 33%. Repeated treatments with the three statins significantly reduced cholesterol levels in the plasma but not in the whole brain. The three statins inhibited in vitro plasma and whole brain ChE activities by 10-33% and 8-43%, respectively. The results suggested that the statins differentially modulated ChE activity in vivo and in vitro in chicks. Additional in vivo studies are warranted on statin effects on ChE activity in different brain regions of animal models.

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“…N-terminal pro b-type natriuretic peptide (NT-proBNP) is a well known biological marker used for the diagnosis and follow-up of patients with heart failure. It can be used to asses the evolution of the disease and to guide the medical decisions [8,9].…”

Section: Introductionmentioning

confidence: 99%

The effect of cardiac pacemaker implantation on cardiac performance – the experience of a Cardiology – Rehabilitation Department

Caloian¹,

Gușetu²,

Costea³

et al. 2018

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Background. Although cardiac pacemakers can prevent the occurrence of heart failure secondary to low cardiac output in patients suffering from extreme bradycardia, they can also induce, in some circumstances, heart failure by decreasing the left ventricular stroke volume. In our study, we aim to describe the effect of permanent cardiac pacing on the evolution of patients with heart failure, objectively determined by the N-terminal pro b-type natriuretic peptide (NT-proBNP) dynamics. Material and methods. Complete clinical examination and determination of NT-proBNP were performed before and 5 days after pacemaker implantation. Results. We enrolled in our study 32 patients with an indication for permanent cardiac pacing in which we implanted 21 single-chamber ventricular pacemakers (VVI, 65.6%), 4 single-chamber atrial pacemakers (AAI, 12.5%) and 7 dual-chamber atrio-ventricular pacemakers (DDD, 21.9%). Patients with heart failure had an average NT-proBNP value of 2542.2±2311.12 pg/mL and patients without heart failure (control group), had an average NT-proBNP value of 190.58±98.16pg/mL. Patients in sinus rhythm that received a VVI pacemaker experienced an increase in NT-proBNP values of 103.73%, while patients in atrial fibrillation and VVI of only 0.27%. NT-proBNP values decreased in patients in sinus rhythm that received a DDD or AAI pacemaker by 20.94%. Conclusion. Permanent cardiac pacemakers are able to influence the clinical status of patients with heart failure, especially if they cause the loss of atrio-ventricular synchronism.

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The Effect of Maximal and Submaximal Exercise Testing on NT-proBNP Levels in Patients with Systolic Heart Failure

Cited by 6 publications

References 21 publications

The profile of cardiovascular risk factors in heart failure obese patients hospitalised in a rehabilitation romanian hospital

The profile of cardiovascular risk factors in heart failure obese patients hospitalised in a rehabilitation romanian hospital

Differential effects of statins on plasma and brain cholinesterase activities in chicks

The effect of cardiac pacemaker implantation on cardiac performance – the experience of a Cardiology – Rehabilitation Department

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