The effect of meal size on postprandial increase in cardiac output

Waaler, B. A.; Eriksen, Morten; Toska, Karin

doi:10.1111/j.1748-1716.1991.tb09125.x

Cited by 55 publications

(61 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 Our findings support previous observations by demonstrating that food intake is indeed accompanied by systemic hemodynamic changes. 34 The decrease in splanchnic vascular resistance as well as the significant fall in dBP under placebo as shown in this study both lead to baroreceptor activation with a subsequent significant increase in HR due to a positive chronotropic effect. These systemic hemodynamic postprandial changes were completely inhibited by lanreotide.…”

Section: Discussionmentioning

confidence: 95%

Hemodynamic effects of the somatostatin analog lanreotide in humans: Placebo-controlled, cross-over dose-ranging echo-doppler study

Mottet¹,

Sieber²,

Nauer³

et al. 1998

Hepatology

View full text Add to dashboard Cite

Because of their vasoactive effects, somatostatin and its analogs are increasingly used in the management of complications of chronic liver diseases such as variceal bleeding. Postprandial hyperemia augments splanchnic blood flow, subsequently increasing portal pressure. The aim of this study was to explore effects of the somatostatin analog, lanreotide, on food-stimulated hemodynamic parameters in healthy human subjects. A dose-response curve was constructed in eight healthy male subjects in a placebo-controlled cross-over study. On 4 different days, either 0 (placebo), 50, 100, or 200 g/h of lanreotide was infused intravenously in random order, starting at 45 minutes for 7 hours. On each day, a liquid test meal (Ensure plus, 1.5 kcal/mL) was perfused intraduodenally at a rate of 3 mL/min over 7 hours after a 45-minute basal period. Diastolic arterial pressure (dBP), heart rate (HR), superior mesenteric arterial (SMA) average flow velocity (SMA-V), SMA pulsatility index (SMA-PI), portal venous volume flow (PV-F), and renal artery (RA) resistance index (RA-RI) were measured on regular intervals (flows using Echo-Doppler technology). Lanreotide at all doses abolished food-stimulated splanchnic hyperemia both in the SMA and PV over 7 hours. The fall in dBP and increase in HR after food perfusion were blunted under lanreotide. Food as well as lanreotide did not modify RA-RI. In summary: 1) lanreotide inhibits food-induced splanchnic hyperemia in normal subjects; 2) in parallel, systemic hemodynamic alterations to food stimulation are abolished with lanreotide; and 3) renal vascular resistance is unchanged. Because of its persistent splanchnic vasoconstrictive effect, lanreotide should be tested in patients with portal hypertension. (HEPATOLOGY 1998;27: 920-925.) Natural somatostatin, and especially its analog, octreotide, are increasingly used in the treatment of esophageal variceal bleeding. [1][2][3][4] In patients with cirrhosis and portal hypertension, it reduces splanchnic and azygos blood flow, 5,6 whereas the action with regard to portal pressure is modest. [5][6][7] Conversely, the effect(s) of natural somatostatin and its analog, octreotide, upon renal hemodynamics and function are unclear and have been a reason for debate. [8][9][10][11] Hemodynamic effects, at least for octreotide, have recently been shown to be only short-lasting, even when the drug is infused constantly. 12 In addition, no clear dose-response with regard to splanchnic hemodynamics has been performed, making a dose justification for the use of this compound difficult.Food is a very potent hyperemic stimulus in the splanchnic vascular area, both in normal subjects, 13-15 as well as in patients with portal hypertension. 16,17 It has been hypothesized that postprandial hyperemia may acutely augment portal pressure, and by this mechanism may probably increase the risk of bleeding from gastroesophageal varices. 18,19 It has also been shown that octreotide blunts this postprandial increase both in normal subjects 20,21 and cirrhotic patients....

show abstract

Section: Discussionmentioning

confidence: 95%

Hemodynamic effects of the somatostatin analog lanreotide in humans: Placebo-controlled, cross-over dose-ranging echo-doppler study

Mottet¹,

Sieber²,

Nauer³

et al. 1998

Hepatology

View full text Add to dashboard Cite

show abstract

“…Meal size has been shown to positively correlate with the increase in intestinal blood flow, and a liquid consistency is believed to accelerate this effect (4,12,18). However, osmolality, volume, and consistency of the food bolus alone do not seem to alter intestinal hemodynamics significantly (2,11).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive assessment of the global and regional vascular responses to food ingestion in humans using novel rapid MRI

Hauser

Muthurangu

Steeden

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Comprehensive assessment of the global and regional vascular responses to food ingestion in humans using novel rapid MRI. Am J Physiol Regul Integr Comp Physiol 310: R541-R545, 2016. First published January 13, 2016 doi:10.1152/ajpregu.00454.2015.-Ingestion of food is known to increase mesenteric blood flow. It is not clear whether this increased flow demand is compensated by a rise in cardiac output (CO) alone or by redistribution of blood flow from other organs. We used a new comprehensive imaging method to assess the human cardiovascular response to food ingestion. Following a 12-h fast, blood flow in segments of the aorta and in organspecific arteries, and ventricular volumes were assessed in 20 healthy adults using MRI at rest and following ingestion of a high-energy liquid meal. Systemic vascular resistance (SVR) fell substantially and CO rose significantly. Blood pressure remained stable. These changes were predominantly driven by a rapid fall in mesenteric vascular resistance, resulting in over four times more intestinal blood flow. Renal vascular resistance also declined but less dramatically. No changes in blood flow to the celiac territory, the brain, or the limbs were observed. In conclusion, this is the first study to fully characterize systemic and regional changes in vascular resistance after food ingestion in humans. Our findings show that the postprandial drop in SVR is fully compensated for by increased CO and not by redistribution of blood from other organs. With the exception of a modest increase in renal blood flow, there was no evidence of altered blood flow to nondigestive organs. The proposed oral food challenge protocol can be applied safely in an MRI environment and may be useful for studying the involvement of the gut in systemic or cardiovascular disease.

show abstract

“…The difference in duration may simply have been due tȯ Vo 2 the variability in the relationship between f H and durinġ Vo 2 digestion (Green et al 2006). Studies of humans have also shown a greater increase in postprandial f H with increasing meal size (Waaler et al 1991;Sidery and Macdonald 1994).…”

Section: Changes In Heart Ratementioning

confidence: 96%

“…Under our experimental conditions, it was not possible for us to ascertain the extent to which this increase in OP was due to a change in cardiac stroke volume and/or oxygen extraction by the tissues. Studies of humans have reported varying contributions of stroke volume to increases in cardiac output associated with digestion, but all report an increase in f H (Waaler et al 1991;Muller et al 1992;Sidery and Macdonald 1994). McPhee et al (2003) detected little or no change in postprandial f H , while increased steadVo 2 ily in Steller sea lions.…”

Section: Changes In Heart Ratementioning

confidence: 99%

Physiological Response to Feeding in Little Penguins

Green¹,

Frappell²,

Butler³

2006

Physiological and Biochemical Zoology

View full text Add to dashboard Cite

Specific dynamic action (SDA), the increase in metabolic rate above resting levels that accompanies the processes of digestion and assimilation of food, can form a substantial part of the daily energy budget of free-ranging animals. We measured heart rate (f H ) and rate of oxygen consumption ( ) in 12 littlė Vo 2 penguins while they digested a meal of sardines in order to determine whether they show specific dynamic action. In contrast to some studies of other penguin species, little penguins showed a substantial SDA, the magnitude of which was proportional to the size of the meal. The energy utilized in SDA was equivalent to 13.4% of the available energy content of the fish. Furthermore, animals such as penguins that forage in a cold environment will probably expend further energy in heating their food to body temperature to facilitate efficient digestion. It is estimated that this additional energy expenditure was equivalent to 1.6%-2.3% of the available energy content of the fish, depending on the time of year and therefore the temperature of the water. Changes in f H during digestion were qualitatively similar to those in , implying that there were nȯ Vo 2 substantial circulatory adjustments during digestion and that the relationship between f H and in penguins is unaffecteḋ Vo 2 by digestive state.

show abstract

The effect of meal size on postprandial increase in cardiac output

Cited by 55 publications

References 11 publications

Hemodynamic effects of the somatostatin analog lanreotide in humans: Placebo-controlled, cross-over dose-ranging echo-doppler study

Hemodynamic effects of the somatostatin analog lanreotide in humans: Placebo-controlled, cross-over dose-ranging echo-doppler study

Comprehensive assessment of the global and regional vascular responses to food ingestion in humans using novel rapid MRI

Physiological Response to Feeding in Little Penguins

Contact Info

Product

Resources

About