The effect of medial meniscectomy on anterior-posterior motion of the knee.

Levy, I. Martin; Torzilli, Peter A.; Warren, Russell F.

doi:10.2106/00004623-198264060-00011

Cited by 760 publications

(419 citation statements)

References 0 publications

Supporting

Mentioning

385

Contrasting

Unclassified

Order By: Relevance

“…1,2 Meniscus has an important role in load transmission, shock absorption, knee stability, and lubrication of the knee joint. [3][4][5][6] Menisci injury may lead to long-term degenerative joint changes, such as osteophyte formation, articular cartilage degeneration, joint space narrowing, and symptomatic osteoarthritis. 1,2 The treatments of meniscal lesion in knee joint include partial or total meniscectomy, meniscus repair, and allogeneic meniscus transplantation.…”

Section: Introductionmentioning

confidence: 99%

Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model

Kang

Son

Lee

et al. 2006

J Biomedical Materials Res

View full text Add to dashboard Cite

Abstract:The current treatments of meniscal lesion in knee joint are not perfect to prevent adverse effects of meniscus injury. Tissue engineering of meniscus using meniscal cells and polymer scaffolds could be an alternative option to treat meniscus injury. This study reports on the regeneration of whole medial meniscus in a rabbit total meniscectomy model using the tissue engineering technique. Biodegradable scaffolds in a meniscal shape were fabricated from polyglycolic acid (PGA) fiber meshes that were mechanically reinforced by bonding PGA fibers at cross points with 75:25 poly(lactic-co-glycolic acid). The compressive modulus of the bonded PGA scaffold was 28-fold higher than that of nonbonded scaffold. Allogeneic meniscal cells were isolated from rabbit meniscus biopsy and cultured in vitro. The expanded meniscal cells were seeded onto the polymer scaffolds, cultured in vitro for 1 week, and transplanted to rabbit knee joints from which medial menisci were removed. Ten or 36 weeks after transplantation, the implants formed neomenisci with the original scaffold shape maintained approximately. Hematoxylin and eosin staining of the sections of the neomenisci at 6 and 10 weeks revealed the regeneration of fibrocartilage. Safranin-O staining showed that abundant proteoglycan was present in the neomenisci at 10 weeks. Masson's trichrome staining indicated the presence of collagen. Immunohistochemical analysis showed that the presence of type I and II collagen in neomenisci at 10 weeks was similar to that of normal meniscal tissue. Biochemical and biomechanical analyses of the tissue-engineered menisci at 36 weeks were performed to determine the quality of the tissue-engineered menisci. Tissue-engineered meniscus showed differences in collagen content and aggregate modulus in comparison with native meniscus. This study demonstrates, for the first time, the feasibility of regenerating whole meniscal cartilage in a rabbit total meniscectomy model using the tissue engineering method.

show abstract

Section: Introductionmentioning

confidence: 99%

Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model

Kang

Son

Lee

et al. 2006

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…After the first historical description of the test by Galway and MacIntosh [30], many other variations have been described by physicians and researchers [31][32][33]. However, research has documented that the interpretation of the pivot shift test remains subjective and examiner dependent [17,[34][35][36][37].…”

Section: Objective Quantification Of Pivot Shift Phenomenamentioning

confidence: 99%

Basic biomechanic principles of knee instability

Zlotnicki

Naendrup

Ferrer

et al. 2016

Curr Rev Musculoskelet Med

View full text Add to dashboard Cite

Motion at the knee joint is a complex mechanical phenomenon. Stability is provided by a combination of static and dynamic structures that work in concert to prevent excessive movement or instability that is inherent in various knee injuries. The anterior cruciate ligament (ACL) is a main stabilizer of the knee, providing both translational and rotatory constraint. Despite the high volume of research directed at native ACL function, pathogenesis and surgical reconstruction of this structure, a gold standard for objective quantification of injury and subsequent repair, has not been demonstrated. Furthermore, recent studies have suggested that novel anatomic structures may play a significant role in knee stability. The use of biomechanical principles and testing techniques provides essential objective/quantitative information on the function of bone, ligaments, joint capsule, and other contributing soft tissues in response to various loading conditions. This review discusses the principles of biomechanics in relation to knee stability, with a focus on the objective quantification of knee stability, the individual contributions of specific knee structures to stability, and the most recent technological advances in the biomechanical evaluation of the knee joint.

show abstract

“…The integral roles the menisci provide to maintaining appropriate function of the knee are well documented in the literature and include load transmission [1], stability and alleviation of tibiofemoral joint incongruity [54,81], shock absorption [91], joint lubrication [17], and proprioception [98]. Injury to the menisci can therefore be exceptionally debilitating.…”

Section: Introductionmentioning

confidence: 99%