The effect of medicinal plants on multiple drug resistance through autophagy: A review of in vitro studies

Sameiyan, Elham; Hayes, A. Wallace; Karimi, Gholamreza

doi:10.1016/j.ejphar.2019.04.001

Cited by 28 publications

(35 citation statements)

References 147 publications

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“…Another group of NCs has been reported to exhibit a modulating response at different stages of autophagy [ 71 ] (Tables 1). These NCs restore inhibition of mitochondrial complex I and increase the AMP/ATP ratio following exposure to rotenone.…”

Section: Protective Effects Of Natural Compounds Against Rotenone‐indmentioning

confidence: 99%

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The protective effect of natural compounds against rotenone‐induced neurotoxicity

Yarmohammadi

Hayes

Najafi

et al. 2020

J Biochem & Molecular Tox

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Rotenone is a widely used organic pesticide; its serious side effect for off-target species is neurotoxicity. The primary mechanism of rotenone toxicity is inhibition of the mitochondrial complex I. Oxidative stress, apoptosis, and reduction of autophagy are key outcomes of the inhibition of complex I. Numerous in vitro and in vivo studies have shown antioxidant, anti-apoptotic, and autophagy enhancement of a variety of natural compounds (NCs). In this manuscript, we reviewed several NCs, which have protective effects against rotenone-induced neurotoxicity.

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Section: Protective Effects Of Natural Compounds Against Rotenone‐indmentioning

confidence: 99%

“…Another group of NCs has been reported to exhibit a modulating response at different stages of autophagy [71] (Tables 1).…”

Section: Protective Effects Of Natural Compounds Against Rotenone-imentioning

confidence: 99%

The protective effect of natural compounds against rotenone‐induced neurotoxicity

Yarmohammadi

Hayes

Najafi

et al. 2020

J Biochem & Molecular Tox

Self Cite

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“…To date, there is a growing body of evidence to suggest that the association between autophagy and cancer is complicated and contradictory (Wen and Klionsky, 2019;Galluzzi and Kroemer, 2020). Autophagy performs various functions in the body; during starvation, this mechanism serves as a cell survival pathway by preparing recycled metabolic substrates as well as keeping energy homeostasis (Sameiyan et al, 2019). Besides, it results in cell death, in association with an apoptosis pathway or as a backup mechanism (Nazim et al, 2020).…”

Section: Apigenin and Programmed Cell Deathmentioning

confidence: 99%

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

et al. 2020

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Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its propensity for early local and distant spread, affected patients possess extremely poor prognosis. Currently applied treatments are not effective enough to eradicate all cancer cells, and minimize their migration. Besides, these treatments are associated with adverse effects on normal cells and organs. These therapies are not able to increase the overall survival rate of patients; hence, finding novel adjuvants or alternatives is so essential. Up to now, medicinal herbs were utilized for therapeutic goals. Herbal-based medicine, as traditional biotherapeutics, were employed for cancer treatment. Of them, apigenin, as a bioactive flavonoid that possesses numerous biological properties (e.g., anti-inflammatory and anti-oxidant effects), has shown substantial anticancer activity. It seems that apigenin is capable of suppressing the proliferation of cancer cells via the induction of cell cycle arrest and apoptosis. Besides, apigenin inhibits metastasis via down-regulation of matrix metalloproteinases and the Akt signaling pathway. In pancreatic cancer cells, apigenin sensitizes cells in chemotherapy, and affects molecular pathways such as the hypoxia inducible factor (HIF), vascular endothelial growth factor (VEGF), and glucose transporter-1 (GLUT-1). Herein, the biotherapeutic activity of apigenin and its mechanisms toward cancer cells are presented in the current review to shed some light on anti-tumor activity of apigenin in different cancers, with an emphasis on pancreatic cancer.

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“…Therefore, the balance of anabolic and catabolic processes is vital; however, the level of growth factors, nutrient and energy in cells, as well as hormonal inputs, define their balance. mTOR pathway plays a significant role in cell fate [43]. Importantly, mTOR protein kinase regulates some cellular anabolic processes and this has a remarkable role in autophagy inhibition [44,45,46,47].…”

Section: Mtor Signaling Pathwaymentioning

confidence: 99%

Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems

et al. 2019

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Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. This knowledge will help scientists find approaches to manipulate tumor and pathologic cells in order to enhance cellular sensitivity to therapeutics and treat them. Although some conventional therapeutics suffer from poor solubility, bioavailability and controlled release mechanisms, it appears that novel nanoplatforms overcome these obstacles and have led to the design of a theranostic-controlled drug release system with high solubility and active targeting and stimuli-responsive potentials. In this review, we discuss autophagy modulators-related signaling pathways and some of the drug delivery strategies that have been applied to the field of therapeutic application of autophagy modulators. Moreover, we describe how therapeutics will target various steps of the autophagic machinery. Furthermore, nano drug delivery platforms for autophagy targeting and co-delivery of autophagy modulators with chemotherapeutics/siRNA, are also discussed.

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The effect of medicinal plants on multiple drug resistance through autophagy: A review of in vitro studies

Cited by 28 publications

References 147 publications

The protective effect of natural compounds against rotenone‐induced neurotoxicity

The protective effect of natural compounds against rotenone‐induced neurotoxicity

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems

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