The effect of melanocortin (Mc3 and Mc4) antagonists on serotonin-induced food and water intake of broiler cockerels

Zendehdel, Morteza; Hamidi, Farshid; Babapour, Vahab; Mokhtarpouriani, Kasra; Fard, Ramin Mazaheri Nezhad

doi:10.4142/jvs.2012.13.3.229

Cited by 26 publications

(13 citation statements)

References 29 publications

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“…For example, in broiler cockerels pre-treatment with melanocortin receptor antagonists attenuates the anorexic effects of icv injections of 5-HT (Zendehdel et al, 2012). In chicks, non-selective CRF receptor antagonists reverse the appetite-suppressing effects of α-MSH (Tachibana et al, 2007) and β-MSH (Kamisoyama et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss)

2013

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Corticotropin-releasing factor (CRF), urotensin I (UI) and serotonin (5-HT) are generally recognized as key regulators of the anorexigenic stress response in vertebrates, yet the proximal effects and potential interactions of these central messengers on food intake in salmonids are not known. Moreover, no study to date in fishes has compared the appetite-suppressing effects of CRF and UI using species-specific peptides. Therefore, the objectives of this study were to (1) assess the individual effects of synthesized rainbow trout CRF (rtCRF), rtUI as well as 5-HT on food intake in rainbow trout, and (2) determine whether the CRF and serotonergic systems interact in the regulation of food intake in this species. Intracerebroventricular (icv) injections of rtCRF and rtUI both suppressed food intake in a dose-related manner but rtUI [ED50 = 17.4 ng/g body weight (BW)] was significantly more potent than rtCRF (ED50 = 105.9 ng/g BW). Co-injection of either rtCRF or rtUI with the CRF receptor antagonist α-hCRF(9–41) blocked the reduction in food intake induced by CRF-related peptides. Icv injections of 5-HT also inhibited feeding in a dose-related manner (ED50 = 14.7 ng/g BW) and these effects were blocked by the serotonergic receptor antagonist methysergide. While the anorexigenic effects of 5-HT were reversed by α-hCRF(9–41) co-injection, the appetite-suppressing effects of either rtCRF or rtUI were not affected by methysergide co-injection. These results identify CRF, UI and 5-HT as anorexigenic agents in rainbow trout, and suggest that 5-HT-induced anorexia may be at least partially mediated by CRF- and/or UI-secreting neurons.

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Section: Discussionmentioning

confidence: 99%

Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss)

2013

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“…The 5-HT 2 c expression in POMC neurons might contribute to this effect. Furthermore, it is suggested that the hypophagic effect of 5-HTergic system is mediated via the melanocortin pathway (Nonogaki et al 2008;Zendehdel et al 2012a). The 5HT 2 c receptors affect appetite regulation via several neurotransmitters (Zendehdel et al 2013a(Zendehdel et al , b, 2014.…”

Section: Discussionmentioning

confidence: 99%

“…The central 5-HTergic system has a potential effect on food intake. Reportedly the intracerebroventricular (ICV) injection of 5-HT has a hypophagic effect on food intake in chicken (Zendehdel et al 2012a(Zendehdel et al , b, 2013a(Zendehdel et al , b, 2014.…”

Section: Introductionmentioning

confidence: 99%

Opioid-induced hypophagia is mediated by 5-HT<sub>2</sub>c receptors in neonatal layer-type chicken

Shojaei¹,

Zendehdel²,

Babapour³

et al. 2015

CZECH J ANIM SCI

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Opioidergic and serotonergic (5-HTergic) systems have crucial role in central regulation of food intake. This study was designed to investigate the role of the opioidergic system and the interaction with the 5-HTergic system in opioid-induced feeding behaviour in 3-h food-deprived (FD 3 ) neonatal layer-type chicks. In total 432 chickens were allocated into 9 experiments, each per 4 treatment groups. In Experiment 1, birds were intracerebroventricularly (ICV) injected with D-Ala2-NMe-Phe4-Glyol5-enkephalin (DAMGO), µ-opioid receptor agonist (125, 250, and 500 pmol). In Experiment 2, chickens were ICV treated with D-Pen 2 , D-Pen 5 enkephalin (D-Pen 2,5 enkephalin, DPDPE), δ-opioid receptor agonist (20, 40, and 80 pmol). In Experiment 3, the effect of ICV injection of U-50488H, κ-opioid receptor agonist (10, 20, and 30 nmol) was investigated in chicks. In Experiment 4, chickens were injected with para-chlorophenylalanine (PCPA), cerebral serotonin depletive (1.5 µg) + DAMGO (125 pmol). In Experiment 5, birds were treated with PCPA (1.5 µg) + DPDPE (40 pmol). In Experiment 6, birds received 1.5 µg PCPA + U-50488H (30 nmol). In Experiments 7-9, birds were injected like in Experiments 4-6, but with SB242084, 5-HT 2 c receptor antagonist (1.5 µg) instead of the PCPA injection. Cumulative food intake was recorded until 3 h post injection. According to the results, the ICV injection of DAMGO significantly decreased whereas that of DPDPE + U-50488H increased food intake (P ≤ 0.05). Co-administration of PCPA + DAMGO significantly decreased hypophagia induced by DAMGO (P ≤ 0.05). PCPA had no effect on DPDPE + U-50488H-induced hyperphagia (P ≥ 0.05). SB242084 significantly attenuated the hypophagic effect of DAMGO (P ≤ 0.05), while SB242084 had no modulatory effect on the food intake induced by DPDPE + U-50488H (P ≥ 0.05). These results suggest that there is an interaction between the opioidergic and 5-HTergic systems mediating the hypophagic effect of µ-opioid receptors via the 5-HT 2 c receptor in neonatal layer-type chicks.

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“…Some of these factors play a similar role in trading off sex for ingestive behavior in other model systems. ( McCann and Hansel 1986 ; Wade et al 1991 ; Heisler et al 1994 ; Bruning et al 2000 ; Sullivan et al 2002 ; Benoit et al 2004 ; Woodside et al 2012 ; Zendehdel et al 2012 ; Blevins and Ho 2013 ; Sabatier et al 2013 ; French et al 2014 ; Lopez-Esparza et al 2015 ; Schellekens et al 2015 ; Santoso et al 2017 ; Woodside 2016 ). This initial 1-h kick-off to the symposium suggested many possibilities for linked genes with pleiotropic and/or antagonistic effects that would constrain phenotypic expression and lead to population divergence due to selection for different optima.…”

Section: Moving Beyond Endocrine Secretionsmentioning

confidence: 99%

Molecular and Neuroendocrine Approaches to Understanding Trade-offs: Food, Sex, Aggression, Stress, and Longevity—An Introduction to the Symposium

Schneider

Deviche

2017

Integrative and Comparative Biology

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SynopsisLife history strategies are composed of multiple fitness components, each of which incurs costs and benefits. Consequently, organisms cannot maximize all fitness components simultaneously. This situation results in a dynamic array of trade-offs in which some fitness traits prevail at the expense of others, often depending on context. The identification of specific constraints and trade-offs has helped elucidate physiological mechanisms that underlie variation in behavioral and physiological life history strategies. There is general recognition that trade-offs are made at the individual and population level, but much remains to be learned concerning the molecular neuroendocrine mechanisms that underlie trade-offs. For example, we still do not know whether the mechanisms that underlie trade-offs at the individual level relate to trade-offs at the population level. To advance our understanding of trade-offs, we organized a group of speakers who study neuroendocrine mechanisms at the interface of traits that are not maximized simultaneously. Speakers were invited to represent research from a wide range of taxa including invertebrates (e.g., worms and insects), fish, nonavian reptiles, birds, and mammals. Three general themes emerged. First, the study of trade-offs requires that we investigate traditional endocrine mechanisms that include hormones, neuropeptides, and their receptors, and in addition, other chemical messengers not traditionally included in endocrinology. The latter group includes growth factors, metabolic intermediates, and molecules of the immune system. Second, the nomenclature and theory of neuroscience that has dominated the study of behavior is being re-evaluated in the face of evidence for the peripheral actions of so-called neuropeptides and neurotransmitters and the behavioral repercussions of these actions. Finally, environmental and ecological contexts continue to be critical in unmasking molecular mechanisms that are hidden when study animals are housed in enclosed spaces, with unlimited food, without competitors or conspecifics, and in constant ambient conditions.

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The effect of melanocortin (Mc3 and Mc4) antagonists on serotonin-induced food and water intake of broiler cockerels

Cited by 26 publications

References 29 publications

Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss)

Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss)

Opioid-induced hypophagia is mediated by 5-HT<sub>2</sub>c receptors in neonatal layer-type chicken

Molecular and Neuroendocrine Approaches to Understanding Trade-offs: Food, Sex, Aggression, Stress, and Longevity—An Introduction to the Symposium

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