2022
DOI: 10.1055/a-1910-0748
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The Effect of Melatonin on Nasal Septal Wound Healing in an Experimental Animal Model

Abstract: Objective: The purpose of our study was to examine the effect of melatonin (MLT) on wound healing in the nasal septum. Methods: Twenty-two Sprague–Dawley rats of the male sex were included in this experimental study. Nasal septal perforation (NSP), about two millimeters in diameter, was formed in each rat. Melatonin was applied to the subjects in the study group and saline was applied to the subjects in the control group once a day for 14 days. On day 14, the rats were sacrificed and the nasal septums of the s… Show more

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Cited by 3 publications
(1 citation statement)
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“…Thus, reducing the size of the perforation may lead to symptom improvement. Therefore, several topical agents have been investigated for the healing of perforations in a rat or rabbit model [ [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] ]. However, effects vary, and no consensus has been reached regarding which agent and method are considered effective.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, reducing the size of the perforation may lead to symptom improvement. Therefore, several topical agents have been investigated for the healing of perforations in a rat or rabbit model [ [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] ]. However, effects vary, and no consensus has been reached regarding which agent and method are considered effective.…”
Section: Discussionmentioning
confidence: 99%