The Effect of Menopausal Status and Sequential Mestranol and Norethisterone on Serum Cholesterol, Triglyceride and Electrophoretic Lipoprotein Patterns

Paterson, M. E. L.; Sturdee, David W.; Moore, B.; Whitehead, T. P.

doi:10.1111/j.1471-0528.1979.tb10698.x

Cited by 19 publications

(6 citation statements)

References 21 publications

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“…The reduction in serum cholesterol with graded sequential mestranol and norethisterone has already been reported (Magnani and Moore, 1976). In the present series there was a + Z l significant reduction in serum cholesterol concentration at all durations of therapy and these reduced levels were similar to those found in age-matched premenopausal women (Paterson et al, 1979). Although there were differences in mean serum cholesterol concentration at the different durations of therapy, these differences did not achieve statistical significance.…”

Section: Discussionsupporting

confidence: 74%

The Effect of Various Regimens of Hormone Therapy on Serum Cholesterol and Triglyceride Concentrations in Postmenopausal Women

Paterson

Sturdee

Moore

et al. 1980

BJOG

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Summary The serum cholesterol and triglyceride concentrations of 84 postmenopausal women both before and after 2, 6 and 12 months therapy with various regimens of hormone therapy were measured. There was little alteration in mean serum cholesterol concentration with cyclical oestrogens but both sequential mestranol and norethisterone and sequential oestradiol valerate and norgestrel significantly reduced the mean serum cholesterol concentration to a level similar to that found in age‐matched premenopausal women. There was a small and sometimes significant rise in serum triglyceride concentration with cyclical oestrogens. Sequential mestranol and norethisterone significantly elevated serum triglyceride levels, but sequential oestradiol valerate and norgestrel significantly depressed them. The results suggest that the progestogenic agent norgestrel has an important role to play in reducing both serum cholesterol and triglyceride levels, and that the sequential preparations, by virtue of their greater cholesterol lowering effect, should perhaps be preferred to cyclical oestrogens.

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Section: Discussionsupporting

confidence: 74%

The Effect of Various Regimens of Hormone Therapy on Serum Cholesterol and Triglyceride Concentrations in Postmenopausal Women

Paterson

Sturdee

Moore

et al. 1980

BJOG

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“…The present study revealed significant differences between the premenopausal untrained group and the postmenopausal untrained group in measures of Tc, LDL-C, HDL-C, HDL/Tc (P < 0.05) and no significance with regard to HDL-C (F> 0.05) ( Table 3). These findings support the notion that menopause adversely alters cholesterol lipid profiles by elevating LDL-C levels since HDL-C levels were not significantly affected by menopause (10,20,29). The present authors hypothesize that this change may predispose postmenopausal women to higher risk for CAD.…”

Section: Discussionsupporting

confidence: 88%

“…Menopause appears to be related to increased heart attack risk (20). Although no cause and effect has yet been established, studies suggest that changes in HDL-C, LDL-C, and Tc that accompany menopause may be responsible for the increased risk (6,9,10,20,29,34). The present study revealed significant differences between the premenopausal untrained group and the postmenopausal untrained group in measures of Tc, LDL-C, HDL-C, HDL/Tc (P < 0.05) and no significance with regard to HDL-C (F> 0.05) ( Table 3).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Menopause and Training on Serum Lipids*

Rainville¹,

Vaccaro²

1984

Int J Sports Med

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Forty women were studied to determine the effect of training and menopause on serum levels of total cholesterol (Tc), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), and the ratio of HDL-C/LDL-C. Subjects were assigned to one of four groups: (a) premenopausal trained runners (Pre-T) (25-75 miles per week) (VO2max 44.82 ml/kg-1 X min-1) (N = 10); (b) premenopausal untrained who took part in no regular aerobic exercise (Pre-UT) (VO2max 28.60 ml/kg-1 X min-1) (N = 10); (c) postmenopausal trained runners (Post-T) (25-65 miles per week) (V02max 40.25 ml/kg-1 X min-1) (N = 10); (d) postmenopausal untrained who took part in no regular aerobic exercise (Post-UT) (VO2max 21.50 ml/kg-1 X min-1) (N = 10). None of the women smoked, were taking oral contraceptives, or any form of hormonal replacement. The postmenopausal women had all undergone natural menopause. Analysis of variance indicated: (a) no significant differences between Pre-T and Pre-UT in measures of Tc (188.04 mg/dl; 206.46 mg/dl) and HDL-C (73.2 mg/dl; 62.10 mg/dl) (P greater than 0.05) and a significant difference between Pre-T and Pre-UT in LDL-C (114.57 mg/dl; 144.57 mg/dl) and HDL-C/LDL-C (0.66; 0.44) (P less than 0.05); (b) no significant differences between Pre-T and Post-T for Tc, HDL-C, LDL-C, and HDL-C/LDL-C (P greater than 0.05); (c) significant differences between Pre-UT and Post-UT in Tc (206.46 mg/dl; 241.15 mg/dl), LDL-C (144.36 mg/dl; 184.85 mg/dl), and HDL-C/LDL-C (0.44; 0.32) (P less than 0.05), and no significant difference between these groups in HDL-C (P greater than 0.05); (d) no significant difference between Post-T and Post-UT in Tc (P greater than 0.05) and significant differences between these groups in measures of HDL-C (74.14 mg/dl; 55.54 mg/dl); LDL-C (141.45 mg/dl; 185.85 mg/dl), and HDL-C/LDL-C (0.57; 0.32) (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Over lapping results have been obtained during investigations on the long-term influence of estrogen withdrawal, either physiological (menopause) or therapeutic (postoophorecto my) on lipid metabolism [7,8); in these con ditions, triglycerides are usually unchanged, while cholesterol increases well above nor mal mean values.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Effect of Oophorectomy on Lipoprotein Metabolism

Pansini¹,

Bergamini²,

Bettocchi³

et al. 1984

Gynecol Obstet Invest

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The influence of steroid hormones on lipoprotein metabolism has been investigated in menstruating women undergoing oophorectomy; indeed, by this procedure, it is possible to alter selectively the secretion of the hormones and thus to determine the influence of their withdrawal on blood lipids. Within 3 months of surgery we observed significant rapid changes in cholesterol levels of total and HDL-bound components (early decrease and subsequent increase) without alteration of the triglyceride component of the lipoproteins. Similar biphasic changes were observed for the apolipoproteins A and B, determined by immunological methods. These results are suggestive of an action of sex hormones on the lipoprotein metabolism, both on the lipid and the protein moieties. They can be explained by a primary action of the hormones on the apolipoprotein metabolism and a secondary apoprotein-mediated effect on the lipid component of the lipoproteins.

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The Effect of Menopausal Status and Sequential Mestranol and Norethisterone on Serum Cholesterol, Triglyceride and Electrophoretic Lipoprotein Patterns

Cited by 19 publications

References 21 publications

The Effect of Various Regimens of Hormone Therapy on Serum Cholesterol and Triglyceride Concentrations in Postmenopausal Women

The Effect of Various Regimens of Hormone Therapy on Serum Cholesterol and Triglyceride Concentrations in Postmenopausal Women

The Effects of Menopause and Training on Serum Lipids*

Short-Term Effect of Oophorectomy on Lipoprotein Metabolism

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