The effect of mercury on the mitochondria

Seydi, Enayatollah; Pourahmad, Jalal

doi:10.1016/b978-0-323-88462-4.00017-1

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…HCQ@ROL‐LNPs solved the limitation of free HCQ application and can specifically target to aHSC. Studies found that inhibiting autophagy of aHSC rather than other liver cells can improve the liver fibrosis 27–29 . Cell fluorescence results of aHSC, qHSC and AML‐12 showed that the uptake of aHSC by HCQ@ROL‐LNPs was significantly higher than qHSC and AML‐12.…”

Section: Discussionmentioning

confidence: 99%

Targeted inhibition of autophagy in hepatic stellate cells by hydroxychloroquine: An effective therapeutic approach for the treatment of liver fibrosis

Hou,

Zhai,

Zhang

et al. 2024

Liver International

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Background and PurposeLiver fibrosis is a wound‐healing reaction which is the main cause of chronic liver diseases worldwide. The activated hepatic stellate cell (aHSC) is the main driving factor in the development of liver fibrosis. Inhibiting autophagy of aHSC can prevent the progression of liver fibrosis, but inhibiting autophagy of other liver cells has opposite effects. Hence, targeted inhibition of autophagy in aHSC is quite necessary for the treatment of liver fibrosis, which prompts us to explore the targeted delivery system of small molecule autophagy inhibitor hydroxychloroquine (HCQ) that can target aHSC and alleviate the liver fibrosis.MethodsThe delivery system of HCQ@retinol‐liposome nanoparticles (HCQ@ROL‐LNPs) targeting aHSC was constructed by the film dispersion and pH‐gradient method. TGF‐β‐induced HSC activation and thioacetamide (TAA)‐induced liver fibrosis mice model were established, and the targeting ability and therapeutic effect of HCQ@ROL‐LNPs in liver fibrosis were studied subsequently in vitro and in vivo.ResultsHCQ@ROL‐LNPs have good homogeneity and stability. They inhibited the autophagy of aHSC selectively by HCQ and reduced the deposition of extracellular matrix (ECM) and the damage to other liver cells. Compared with the free HCQ and HCQ@LNPs, HCQ@ROL‐LNPs had good targeting ability, showing enhanced therapeutic effect and low toxicity to other organs.ConclusionConstruction of HCQ@ROL‐LNPs delivery system lays a theoretical and experimental foundation for the treatment of liver fibrosis and promotes the development of clinical therapeutic drugs for liver diseases.

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Section: Discussionmentioning

confidence: 99%

Targeted inhibition of autophagy in hepatic stellate cells by hydroxychloroquine: An effective therapeutic approach for the treatment of liver fibrosis

Hou,

Zhai,

Zhang

et al. 2024

Liver International

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“…Humans and other living organisms are exposed to these elements via oral ingestion, inhalation, and skin contact (Sanaei et al., 2021 ). Heavy metals, such as mercury (Hg), lead (Pb), cadmium (Cd), and arsenic (As), have irreparable effects on health, even in small amounts (El‐Ghiaty & El‐Kadi, 2023 ; Seydi & Pourahmad, 2023 ; Wang et al., 2021 ). They have acute and chronic toxicity on different body organs.…”

Section: Introductionmentioning

confidence: 99%

“…on health, even in small amounts (El-Ghiaty & El-Kadi, 2023;Seydi & Pourahmad, 2023;Wang et al, 2021). They have acute and chronic toxicity on different body organs.…”

mentioning

confidence: 99%

Investigation of the simulated microgravity impact on heavy metal biosorption by Saccharomyces cerevisiae

Salavatifar,

Khosravi‐Darani

2024

Food Science & Nutrition

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Heavy metals are one of the most dangerous environmental pollutions, and their elimination is one of the health system's priorities. Microorganisms have been introduced as a safe absorber of such pollution and this ability is related to the characteristics of their surface layers. There are reports about some bacteria's increment of cell envelope thickness in space conditions. Therefore, this study investigated SMG effect on heavy metals biosorption using Saccharomyces (S.) cerevisiae. Furthermore, the stability of complex, isotherm, and kinetic absorption models has been investigated. The results showed that the SMG positively affected the biosorption of mercury (Hg) 97% and lead (Pb) 72.5% by S. cerevisiae. In contrast, it did not affect cadmium (Cd) and arsenic (As) biosorption. In gastrointestinal conditions, Hg, Cd, and As‐yeast complexes were stable, and their biosorption increased. In the case of the Pb‐yeast complex, in simulated gastric exposure, the binding decreased at first but increased again in simulated intestinal exposure in both SMG and normal gravity (NG). The metals' biosorption by yeast followed the pseudo‐second‐order kinetic and the Langmuir isotherm models for all metals (As) matched with Langmuir and Freundlich. The current research results demonstrate that microgravity provides desirable conditions for heavy metal biosorption by S. cerevisiae. Furthermore, the biosorbent–heavy metal complex remains stable after simulated gastrointestinal conditions. Altogether, the results of this study could be considered in detoxifying food and beverage industries and maintaining astronauts' health.

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Potentials of microbe-plant assisted bioremediation in reclaiming heavy metal polluted soil environments for sustainable agriculture

Omotayo,

Omotayo

2024

Environmental and Sustainability Indicators

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The effect of mercury on the mitochondria

Cited by 3 publications

References 47 publications

Targeted inhibition of autophagy in hepatic stellate cells by hydroxychloroquine: An effective therapeutic approach for the treatment of liver fibrosis

Targeted inhibition of autophagy in hepatic stellate cells by hydroxychloroquine: An effective therapeutic approach for the treatment of liver fibrosis

Investigation of the simulated microgravity impact on heavy metal biosorption by Saccharomyces cerevisiae

Potentials of microbe-plant assisted bioremediation in reclaiming heavy metal polluted soil environments for sustainable agriculture

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