The effect of mesenchymal stromal cells ın the microenvironment on cancer development

Sağlam-Uçar, Özlem; Değirmenci, İrfan; Halbutoğulları, Zehra Seda; Pösteki, Gökhan; Subaşi-Demirci, Cansu; Erman, Gülay; Karaöz, Erdal; Utkan, Nihat Zafer

doi:10.1007/s12032-022-01703-1

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, they are immune-evasive [ 10 , 11 ]. They have also been shown to secrete extracellular vesicles into the extracellular space to regulate and maintain tissue homeostasis through mechanisms of paracrine signaling [ 12 , 13 ]. MSCs can act as potent pro- and anti-inflammatory, angiogenic, and self-renewal-inducing cells, which makes them suitable to be used in regenerative medicine/advanced therapy applications [ [14] , [15] , [16] , [17] ].…”

Section: Introductionmentioning

confidence: 99%

Platelet lysate for expansion or osteogenic differentiation of bone marrow mesenchymal stem cells for 3D tissue constructs

Anerillas

Wiberg

Kingham

et al. 2023

Regenerative Therapy

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Platelet lysate for expansion or osteogenic differentiation of bone marrow mesenchymal stem cells for 3D tissue constructs

Anerillas

Wiberg

Kingham

et al. 2023

Regenerative Therapy

View full text Add to dashboard Cite

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Zhang,

Yue,

Chen

et al. 2023

Mol Cancer

102

View full text Add to dashboard Cite

Despite centuries since the discovery and study of cancer, cancer is still a lethal and intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as a pivotal component of the tumor microenvironment. The versatility and sophisticated mechanisms of CAFs in facilitating cancer progression have been elucidated extensively, including promoting cancer angiogenesis and metastasis, inducing drug resistance, reshaping the extracellular matrix, and developing an immunosuppressive microenvironment. Owing to their robust tumor-promoting function, CAFs are considered a promising target for oncotherapy. However, CAFs are a highly heterogeneous group of cells. Some subpopulations exert an inhibitory role in tumor growth, which implies that CAF-targeting approaches must be more precise and individualized. This review comprehensively summarize the origin, phenotypical, and functional heterogeneity of CAFs. More importantly, we underscore advances in strategies and clinical trials to target CAF in various cancers, and we also summarize progressions of CAF in cancer immunotherapy.

show abstract

The effect of mesenchymal stromal cells ın the microenvironment on cancer development

Cited by 2 publications

References 44 publications

Platelet lysate for expansion or osteogenic differentiation of bone marrow mesenchymal stem cells for 3D tissue constructs

Platelet lysate for expansion or osteogenic differentiation of bone marrow mesenchymal stem cells for 3D tissue constructs

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Contact Info

Product

Resources

About