Depression is the most prevalent psychiatric disorder and has received more attention due to its adverse outcomes, including suicide and a severe decrease in social and individual functioning. To this end, the present study examined the effect of movement therapy and progressive muscle relaxation on the depression rate in depressed patients. In the present interventional study, 60 patients diagnosed with major depression and hospitalized at Moradi Hospital's psychiatric ward in Rafsanjan in 2020, with an age of at least 20 years, were randomly divided into two groups: the intervention group and the control group. The subjects in the intervention group attended 30 sessions of 30–45 mins, with the researcher performing a movement therapy program followed by 15 to 20 minutes of progressive muscle relaxation. The Beck Depression Inventory was used to measure the degree of depression along with clinical pre-and post-intervention interviews. The mean depression scores were 37.26±7.70 and 36.93±8.166 for the participants in the intervention group and control group before the intervention, indicating no statistically significant intergroup difference (P=0.871). The mean depression scores after the intervention for the subjects in the intervention group and control group were 8.01±5.22 and 22.96±9.43, respectively. The results showed a statistically significant difference between the groups (P=0.001), with a greater decrease in depression scores in the intervention group compared to the control group. According to the present research, movement therapy and progressive muscle relaxation interventions effectively reduced depression in patients.