The effect of metal ions released from different dental implant-abutment couples on osteoblast function and secretion of bone resorbing mediators

Alrabeah, Ghada; Brett, Peter; Knowles, Jonathan C.; Petridis, Haralampos

doi:10.1016/j.jdent.2017.08.002

Cited by 73 publications

(52 citation statements)

References 50 publications

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“…With time, orthopedic implants may display some bone loss called “aseptic loosening” and is the most common reason for secondary implant failure, which is related to wear products from the hip implant with activation of the innate and adaptive immune systems . This orthopedic notion may be compared to a recent in vitro analysis of dental implants that demonstrated leaked out metal ions to activate the regulation of bone resorbing mediators . The aseptic loosening of a hip arthroplasty is similar to the dental implant in that bone is gradually lost starting from the highest level of bone contact and, if continuous, gradually will remove more and more bone along the body of the implant.…”

Section: Methodsmentioning

confidence: 99%

On inflammation‐immunological balance theory—A critical apprehension of disease concepts around implants: Mucositis and marginal bone loss may represent normal conditions and not necessarily a state of disease

Albrektsson

Jemt

Mölne

et al. 2018

Clin Implant Dent Rel Res

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Background Oral implants have displayed clinical survival results at the 95%‐99% level for over 10 years of follow up. Nevertheless, some clinical researchers see implant disease as a most common phenomenon. Oral implants are regarded to display disease in the form of mucositis or peri‐implantitis. One purpose of the present article is to investigate whether a state of disease is necessarily occurring when implants display soft tissue inflammation or partially lose their bony attachment. Another purpose of this article is to analyze the mode of defense for implants that are placed in a bacteria rich environment and to analyze when an obtained steady state between tissue and the foreign materials is disturbed. Materials and Methods The present article is authored as a narrative review contribution. Results Evidence is presented that further documents the fact that implants are but foreign bodies that elicit a foreign body response when placed in bone tissue. The foreign body response is characterized by a bony demarcation of implants in combination with a chronic inflammation in soft tissues. Oral implants survive in the bacteria‐rich environments where they are placed due to a dual defense system in form of chronic inflammation coupled to immunological cellular actions. Clear evidence is presented that questions the automatic diagnostics of an oral implant disease based on the finding of so called mucositis that in many instances represents but a normal tissue response to foreign body implants instead of disease. Furthermore, neither is marginal bone loss around implants necessarily indicative of a disease; the challenge to the implant represented by bone resorption may be successfully counteracted by local defense mechanisms and a new tissue‐implant steady state may evolve. Similar reactions including chronic inflammation occur in the interface of orthopedic implants that display similarly good long‐term results as do oral implants, if mainly evaluated based on revision surgery in orthopedic cases. The most common mode of failure of orthopedic implants is aseptic loosening which has been found coupled to a reactivation of the inflammatory‐ immune system. Conclusions Implants survive in the body due to balanced defense reactions in form of chronic inflammation and activation of the innate immune system. Ten year results of oral and hip /knee implants are hence in the 90+ percentage region. Clinical problems may occur with bone resorption that in most cases is successfully counterbalanced by the defense/healing systems. However, in certain instances implant failure will ensue characterized by bacterial attacks and/or by reactivation of the immune system that now will act to remove the foreign bodies from the tissues.

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Section: Methodsmentioning

confidence: 99%

On inflammation‐immunological balance theory—A critical apprehension of disease concepts around implants: Mucositis and marginal bone loss may represent normal conditions and not necessarily a state of disease

Albrektsson

Jemt

Mölne

et al. 2018

Clin Implant Dent Rel Res

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“…Constructs that do not undergo any additional post‐manufacturing modifications can possess partially sintered particles on the implant surface. These remaining microparticles could detach during implant placement, and small particulate of metals are cytotoxic (Alrabeah, Brett, Knowles, & Petridis, ). For this reason, following HIP treatment, constructs were grit‐blasted and acid‐etched as described previously (Cheng et al, ; Cheng, Cohen, Boyan, & Schwartz, ).…”

Section: Methodsmentioning

confidence: 99%

Hot isostatic pressure treatment of 3D printed Ti6Al4V alters surface modifications and cellular response

et al. 2019

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Additive manufacturing can be used to create personalized orthopedic and dental implants with varying geometries and porosities meant to mimic morphological properties of bone. These qualities can alleviate stress shielding and increase osseointegration through bone ingrowth, but at the expense of reduced fatigue properties compared to machined implants, and potential for loose build particle erosion. Hot isostatic pressure (HIP) treatment is used to increase fatigue resistance; implant surface treatments like grit‐blasting and acid‐etching create microroughness and reduce the presence of loose particles. However, it is not known how HIP treatment affects surface treatments and osseointegration of the implant to bone. We manufactured two titanium–aluminum–vanadium constructs, one with simple through‐and‐through porosity and one possessing complex trabecular bone‐like porosity. We observed HIP treatment varied in effect and was dependent on architecture. Micro/meso/nano surface properties generated by grit‐blasting and acid‐etching were altered on biomimetic HIP‐treated constructs. Human mesenchymal stem cells (MSCs) were cultured on constructs fabricated +/− HIP and subsequently surface‐treated. MSCs were sensitive to 3D‐architecture, exhibiting greater osteogenic differentiation on constructs with complex trabecular bone‐like porosity. HIP‐treatment did not alter the osteogenic response of MSCs to these constructs. Thus, HIP may provide mechanical and biological advantages during implant osseointegration and function.

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“…High biotolerance of the cobalt alloys are caused by the passive layer created on their surface [3][4][5]. The use of chromium as an alloy additive affects the spontaneously forming chromium oxide, which is the main component forming the passive layer.…”

Section: Introductionmentioning

confidence: 99%

Application of thermal analysis in the selection of polymer components used as a binder for metal injection moulding of Co–Cr–Mo alloy powder

Matula

Tomiczek

Król

et al. 2018

J Therm Anal Calorim

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To produce the polymer-powder slurry for injection moulding the thermoplastic polymers such as polypropylene, highdensity polyethylene and ethylene-vinyl acetate were used. Depending on skeletal polymers, in every feedstock paraffin wax (PW) was used in the amount of 50% of binder. Application of PW gives the possibility using solvent debinding or thermal debinding at a lower temperature. Then the open porosity into the injected samples reduces the time of thermal debinding of binder residue. Application of one type of skeletal polymer requires using a long isothermal step. The use of a blend of skeletal polymers enables subsequent thermal degradation which consecutively removes skeletal polymers during the heating to the sintering temperature, to minimise the time of isothermal stops. The rheological properties of blends used as a binder and next feedstocks were investigated during mixing in the twin-screw extruder and capillary rheometer. This results gives the information about the possibility to produce feedstocks and then to their injection moulding. Thermal behaviour of samples was determined by differential scanning calorimetry and thermogravimetric analysis to obtain the information about the temperature of mixing the polymers and to propose the thermal debinding cycle.

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The effect of metal ions released from different dental implant-abutment couples on osteoblast function and secretion of bone resorbing mediators

Cited by 73 publications

References 50 publications

On inflammation‐immunological balance theory—A critical apprehension of disease concepts around implants: Mucositis and marginal bone loss may represent normal conditions and not necessarily a state of disease

On inflammation‐immunological balance theory—A critical apprehension of disease concepts around implants: Mucositis and marginal bone loss may represent normal conditions and not necessarily a state of disease

Hot isostatic pressure treatment of 3D printed Ti6Al4V alters surface modifications and cellular response

Application of thermal analysis in the selection of polymer components used as a binder for metal injection moulding of Co–Cr–Mo alloy powder

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