The effect of metallic magnesium degradation products on osteoclast-induced osteolysis and attenuation of NF-κB and NFATc1 signaling

Zhai, Zanjing; Qu, Xinhua; Li, Haowei; Yang, Ke; Wan, Peng; Tan, Lili; Ouyang, Zhengxiao; Liu, Xuqiang; Tian, Bo; Xiao, Fei; Wang, Wengang; Jiang, Chuan; Tang, Tingting; Fan, Qiming; Qin, An; Dai, Kerong

doi:10.1016/j.biomaterials.2014.04.044

Cited by 181 publications

(157 citation statements)

References 40 publications

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“…Early mineralization of the callus was enhanced and then continued normally. Furthermore, the Mg2Ag alloy reduced the number and activity of osteoclasts, a finding that is consistent with our in vitro observations and with the results reported by others [26,31,35]. Thus, the increased callus formation mediated by intramedullary Mg2Ag implants during fracture healing in mice is probably due to both an increase in bone formation and a decrease in bone resorption.…”

Section: Discussionsupporting

confidence: 82%

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Jähn¹,

Saito

Taipaleenmäki

et al. 2016

Acta Biomaterialia

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Intramedullary stabilization is frequently used to treat long bone fractures. Implants usually remain unless complications arise. Since implant removal can become technically very challenging with the potential to cause further tissue damage, biodegradable materials are emerging as alternative options. Magnesium (Mg)-based biodegradable implants have a controllable degradation rate and good tissue compatibility, which makes them attractive for musculoskeletal research. Here we report for the first time the implantation of intramedullary nails made of an Mg alloy containing 2% silver (Mg2Ag) into intact and fractured femora of mice. Prior in vitro analyses revealed an inhibitory effect of Mg2Ag degradation products on osteoclast differentiation and function with no impair of osteoblast function. In vivo, Mg2Ag implants degraded under non-fracture and fracture conditions within 210 days and 133 days, respectively. During fracture repair, osteoblast function and subsequent bone formation were enhanced, while osteoclast activity and bone resorption were decreased, leading to an augmented callus formation. We observed a widening of the femoral shaft under steady state and regenerating conditions, which was at least in part due to an uncoupled bone remodeling. However, Mg2Ag implants did not cause any systemic adverse effects. These data suggest that Mg2Ag implants might be promising for intramedullary fixation of long bone fractures, a novel concept that has to be further investigated in future studies.

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Section: Discussionsupporting

confidence: 82%

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Jähn¹,

Saito

Taipaleenmäki

et al. 2016

Acta Biomaterialia

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show abstract

“…As described previously [11,13,27], a calvarial model of titanium particle-induced osteolysis was used in 7 to 8-week-old male C57BL/ 6 J mice (n ¼ 84), obtained from the Experimental Animal Center of Soochow University. Briefly, mice were randomly divided into four groups: sham control (sham), Ti particles only (vehicle), and Ti particles with low (0.1 mg/g/day) or high (0.3 mg/g/day) concentrations of icariin (low-icariin and high-icariin groups, respectively; Sigma, St. Louis, MO, USA).…”

Section: Animalsmentioning

confidence: 99%

Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model

et al. 2015

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“…Total hip arthroplasty (THA) is considered the most effective treatment for severe trauma, rheumatoid arthritis and other end-stage joint diseases [1]. However, periprosthetic osteolysis and subsequent aseptic loosening (AL) remain the most common reasons for total hip arthroplasty (THA) failure and revision http surgery [2,3].…”

Section: Introductionmentioning

confidence: 99%

The fibroblast expression of RANKL in CoCrMo-particle-induced osteolysis is mediated by ER stress and XBP1s

et al. 2015

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The effect of metallic magnesium degradation products on osteoclast-induced osteolysis and attenuation of NF-κB and NFATc1 signaling

Cited by 181 publications

References 40 publications

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model

The fibroblast expression of RANKL in CoCrMo-particle-induced osteolysis is mediated by ER stress and XBP1s

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