The effect of metformin treatment to ovarian response in cases with PCOS

Abstract

Metformin therapy has led to a higher pregnancy outcome, as well as to a decrease in hyperstimulation risk, cycle cancellations, and multiple pregnancy rates with a lower gonadotropin dosage.

RETRACTED: Effect of metformin pretreatment on pregnancy outcome of in vitro matured oocytes retrieved from women with polycystic ovary syndrome

“…Administration of metformin was shown to improve ovarian response to exogenous gonadotropin in women with CC-resistant PCOS (6,8), the dosage of gonadotropins administrated was reduced, as well as a higher pregnancy outcome achieved, by the administration of metformin (11). Studies have elucidated the effect of metformin treatment before IVF in patients with PCOS, which show more mature oocytes collected and higher clinical pregnancy rates obtained than the control group (16,18).…”

“…Furthermore, metformin administration has been shown to improve ovarian response to exogenous gonadotropin in women with CC-resistant PCOS (6,8). It also has been reported that the dosage of gonadotropins administrated was reduced and a higher pregnancy outcome was achieved by the administration of metformin (11).…”

Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

“…A total of 28 RCTs potentially resulted for inclusion in the meta-analysis (22,, but of these 11 studies were excluded. In particular, the abortion rate was not evaluated in two studies (35,50), data on the abortion rate were not available from papers and could not be obtained from the investigators after E-mail contact for five studies (30,37,44,53,54), and it was not possible to contact the corresponding investigators for four studies (31,33,47,49). Thus, a total of 17 RCTs (22, 32, 34, 36, 38-43, 45, 46, 48, 51, 52, 55, 56) were included in the final analysis.…”

Association between ovarian stimulators with or without intrauterine insemination, and assisted reproductive technologies on multiple births

“…This later conclusion was based on three studies with small sample sizes and not necessary designed to establish the risk of multiple births. [47][48][49] . A potential effect of the metformin, used to increase the ovarian response to ovarian stimulators through the reduction of insulin levels in PCOS subfertile women, on the risk of multiple births,noted in this study, merits investigation.…”