The Effect of Methionine and Threonine Supplementations on Immune Responses of Broiler Chickens Challenged with Infectious Bursal Disease

Abstract

Problem statement:The aim of this study was conducted to determine the effects of supplementing methionine and threonine higher than the National Research Council (NRC) recommendation in the diets on immune responses of broiler chickens challenged with Infectious Bursal Disease (IBD). Approach: A total of 450 day-old male broiler chicks were assigned to one of the nine dietary treatments. Three levels of methionine (NRC (M1), 2 times NRC (M2) and 3 times NRC (M3)) and 3 levels of threonine (NRC (T1), 2 times NRC (T2) and 3 times NRC (T3)) were fed. On day 28, all birds were challenged with a commercial live-IBDV vaccine. Results: Antibody titer against IBD and ND were influenced by interaction of threonine and methionine. On 7 days after IBD challenge, ND antibody titer of the broilers receiving the highest level of methionine and threonine was significantly higher than that of other treatment groups. Lesion score of the bursa of the broilers receiving control diet was significantly the highest compared with the other treatments. Conclusion/Recommendations:The results obtained on the present study indicated that threonine and methionine requirements of broiler based on recommendation of NRC are not sufficient to meet the requirement of the new commercial poultry and commercial broiler companies under non-hygienic condition.

Effects of different sulphur amino acids and dietary electrolyte balance levels on performance, jejunal morphology, and immunocompetence of broiler chicks

“…Different levels of DEB (Borges, ; Borges et al, ; Ahmad et al., ) as well as SAA (Weissman et al., ; Maroufyan et al., ) when administered individually have remarkable effects on performance and immunological parameters. Investigation of their interactions for additive or reductive effects with respect to the above‐mentioned parameters should be interesting because manipulations in DEB have been shown to affect the metabolic pathway and the fate of some amino acids such as lysine and leucine (Adekunmisi and Robbins, ,b; Brake et al., ).…”

“…DEB (Borges, ; Borges et al., ; Ahmad et al., ) or Met (Weissman et al., ; Maroufyan et al., ) each has its own remarkable effects on the performance and immunological responses of birds. The interactions between these two factors could, therefore, be of great interest because of the possible reciprocal relationship(s) between DEB and amino acid metabolism (Patience et al., ; Brake et al., ).…”

Effect of threonine and potassium carbonate supplementation on performance, immune response and bone parameters of broiler chickens

“…Therefore, taking threonine into the feed formulation matrix would be a critical limitation in order to use of other EAAs such as total suphur AAs and Lys in the body efficiently (Kidd 2000). Some researcher have shown that excess dietary threonine promoted broiler chicken performance (Rezaeipour et al 2012), immunological responses through increasing the relative weight of immune organs, synthesis of immunoglobulin A (IgA), immunoglobulin G (IgG), and secretory IgA (Corzo et al 2007;Maroufyan et al 2010;Ren et al 2014).…”

Assessment of Nutritional Value of Single‐Cell Protein from Waste‐Activated Sludge as a Protein Supplement in Poultry Feed

“…However, the high levels of methionine and cysteine compensates for the tryptophan deficiency. Chicks grown on feed rich in these amino acids (in the absence of tryptophan) were shown to develop resistance to the infectious form of Bursal Disease, thereby compensating for the lack in tryptophan (Maroufyan et al, 2010).…”