The effect of methylphenidate on sustained attention among adolescents with attention-deficit hyperactivity disorder

Lufi, Dubi; Bassin-Savion, Shiry; Rubel, Lilach

doi:10.1080/13554794.2015.1023317

Cited by 5 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that MPH decreased misses and false alarms, and led to faster responses compared to placebo (Figure 3). These results replicate previous findings obtained with this dataset (Dockree et al, 2017) and others within the literature (Solanto, 1998; Spencer et al, 2009; Nandam et al, 2011; Bedard et al, 2015; Lufi et al, 2015). The beneficial effect of MPH could stem from its combined effect on both dopamine and noradrenaline, neuromodulators involved in cortical activation (Jones, 2005), sensory processing (Sara and Bouret, 2012) and motivation (Robbins, 1997).…”

Section: Discussionsupporting

confidence: 93%

Pharmacological manipulations of physiological arousal and sleep-like slow waves modulate sustained attention

Pinggal

Dockree

O’Connell

et al. 2022

Preprint

View full text Add to dashboard Cite

Sustained attention describes our ability to keep a constant focus on a given task. This ability is modulated by our physiological state of arousal. Although lapses of sustained attention have been linked with dysregulations of arousal, the underlying physiological mechanisms remain unclear. An emerging body of work proposes that the intrusion during wakefulness of sleep-like slow waves, a marker of the transition toward sleep, could mechanistically account for attentional lapses. This study aimed to expose, via pharmacological manipulations of the monoamine system, the relationship between the occurrence of sleep-like slow waves and the behavioural consequences of sustained attention failures. In a double-blind, randomised-control trial, 32 healthy participants received methylphenidate, atomoxetine, citalopram or placebo during four separate experimental sessions. During each session, electroencephalography (EEG) was used to measure neural activity whilst participants completed a visual task requiring sustained attention. Methylphenidate, which increases wake-promoting dopamine and noradrenaline across cortical and subcortical areas, improved behavioural performance whereas atomoxetine, which increases dopamine and noradrenaline predominantly over frontal cortices, led to more impulsive responses. Additionally, citalopram, which increases sleep-promoting serotonin, led to more missed trials. Based on EEG recording, citalopram was also associated with an increase in sleep-like slow waves. Importantly, compared to a classical marker of arousal such as alpha power, only slow waves differentially predicted both slower and faster responses in a region-specific fashion. These results suggest that a decrease in arousal can lead to local sleep intrusions during wakefulness which could be mechanistically linked to impulsivity and sluggishness.

show abstract

Section: Discussionsupporting

confidence: 93%

Pharmacological manipulations of physiological arousal and sleep-like slow waves modulate sustained attention

Pinggal

Dockree

O’Connell

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…These effects were paralleled by stable subjective reports of sleepiness (Figure S1), meaning that participants did not experience the classical build-up of fatigue with time-on-task. These results replicate previous findings in this dataset (Dockree et al, 2017) and others within the literature (Bedard et al, 2015;Lufi et al, 2015;Nandam et al, 2011;Solanto, 1998;Spencer et al, 2009). The beneficial effect of MPH could stem from its combined effect on both dopamine and noradrenaline, neuromodulators involved in cortical activation (Jones, 2005) and motivation (Robbins, 1997).…”

Section: Sustained Attention Is Fine-tuned By Neuromodulatorssupporting

confidence: 90%

Pharmacological Manipulations of Physiological Arousal and Sleep-Like Slow Waves Modulate Sustained Attention

et al. 2022

View full text Add to dashboard Cite

Sustained attention describes our ability to keep a constant focus on a given task. This ability is modulated by our physiological state of arousal. Although lapses of sustained attention have been linked with dysregulations of arousal, the underlying physiological mechanisms remain unclear. An emerging body of work proposes that the intrusion during wakefulness of sleeplike slow waves, a marker of the transition toward sleep, could mechanistically account for attentional lapses. This study aimed to expose, via pharmacological manipulations of the monoamine system, the relationship between the occurrence of sleep-like slow waves and the behavioural consequences of sustained attention failures. In a double-blind, randomisedcontrol trial, 32 healthy participants received methylphenidate, atomoxetine, citalopram or placebo during four separate experimental sessions. During each session, electroencephalography (EEG) was used to measure neural activity whilst participants completed a visual task requiring sustained attention. Methylphenidate, which increases wakepromoting dopamine and noradrenaline across cortical and subcortical areas, improved behavioural performance whereas atomoxetine, which increases dopamine and noradrenaline predominantly over frontal cortices, led to more impulsive responses. Additionally, citalopram, which increases sleep-promoting serotonin, led to more missed trials. Based on EEG recording, citalopram was also associated with an increase in sleep-like slow waves. Importantly, compared to a classical marker of arousal such as alpha power, only slow waves differentially predicted both slower and faster responses in a region-specific fashion. These results suggest that a decrease in arousal can lead to local sleep intrusions during wakefulness which could be mechanistically linked to impulsivity and sluggishness..

show abstract

Methylphenidate selectively modulates one sub-component of the no-go P3 in pediatric ADHD medication responders

Aasen

Øgrim

Kropotov

et al. 2018

Biological Psychology

View full text Add to dashboard Cite

Methylphenidate (MPH) has been shown to modulate the amplitude of the no-go P3 component of the event-related potential (ERP; Øgrim, Aasen, & Brunner, 2016). Using group independent component analysis, the no-go P3 from a cued go/no-go task has been separated into two sub-components (Brunner et al., 2013). This study investigated whether sub-components of the no-go P3 could be identified in children with ADHD, and how MPH modulates their amplitudes. ERPs were registered twice (on/off MPH) in 57 children with ADHD classified as medication responders in a four-week medication trial. Two no-go P3 sub-components were identified. In the MPH session, the amplitude of one sub-component, the IC P3no-go (mean latency 378 ms, with a central distribution), was significantly larger than at baseline, whereas the other sub-component, the IC P3no-go (mean latency 428 ms, with a centro-frontal distribution), was not significantly affected. These results add to the literature documenting that the no-go P3 consists of two overlapping phenomena with different functional correlates.

show abstract

The effect of methylphenidate on sustained attention among adolescents with attention-deficit hyperactivity disorder

Cited by 5 publications

References 27 publications

Pharmacological manipulations of physiological arousal and sleep-like slow waves modulate sustained attention

Pharmacological manipulations of physiological arousal and sleep-like slow waves modulate sustained attention

Pharmacological Manipulations of Physiological Arousal and Sleep-Like Slow Waves Modulate Sustained Attention

Methylphenidate selectively modulates one sub-component of the no-go P3 in pediatric ADHD medication responders

Contact Info

Product

Resources

About