The effect of metronidazole on vaginal microbiology and maternal and neonatal hematology

Kotcher, Emil; Frick, Carolyn A.; Giesel, L.O.

doi:10.1016/0002-9378(64)90253-4

Cited by 13 publications

(5 citation statements)

References 2 publications

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“…6 There seems no reason why the newborn vagina should not become colonized with Trichomonas vaginalis if the protozoon is encountered during delivery. It is however sterile and alkaline.…”

Section: Discussionmentioning

confidence: 99%

Trichomonas Vaginitis and Escherichia coli Urinary Infection in a Newborn Infant

Postlethwaite

1975

Clin Pediatr (Phila)

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“…6 There seems no reason why the newborn vagina should not become colonized with Trichomonas vaginalis if the protozoon is encountered during delivery. It is however sterile and alkaline.…”

Section: Discussionmentioning

confidence: 99%

Trichomonas Vaginitis and Escherichia coli Urinary Infection in a Newborn Infant

Postlethwaite

1975

Clin Pediatr (Phila)

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“…No congenital abnormalities were noted. Kotcher et al 21 treated 36 pregnant women with metronidazole in the third trimester. Of the 34 babies for which outcome was known, one had a congenital defect: a crooked foot.…”

Section: Watt and Jennisonmentioning

confidence: 99%

“…These authors reported an increased risk of spontaneous abortion in patients prescribed metronidazole in the 120-day period prior to spon-taneous abortion compared with those prescribed metronidazole 300-180 days prior to delivery; no excess risk was found when the population was compared with women who underwent elective abortion. The authors state that metronidazole therapy is frequently avoided during pregnancy; this may reflect no avoidance of therapy prior to elective abortions, compared with avoidance of [42] Umbilical hernia Hydrocephalus Small skin tags on ear Scott-Gray [11] Microcephaly + meningocele Multiple defects Cardiac lesion Mild hydrocephaly Watt, Jennison [17] Anencephaly Sands [16] Polydactyly (familial) Kotcher [21] Crooked foot Zacharias [18] Rh factor (stillborn) Cantú [30] Midline facial defects (I) *Roman numeral following defect indicates trimester treated, when reported.…”

Section: Human Studiesmentioning

confidence: 99%

Metronidazole appears not to be a human teratogen: Review of literature

Struthers¹

1997

Infect. Dis. Obstet. Gynecol.

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Metronidazole is used to treat trichomoniasis, bacterial vaginosis, and other diseases. As is the case with many drugs, physicians often hesitate to use it during pregnancy, particularly in the first trimester. A review of the nearly four decades' worth of published literature on metronidazole use in pregnant women indicates that it is not teratogenic, regardless of the trimester in which it is used. On the other hand, a number of published studies indicate that bacterial vaginosis and trichomoniasis are associated with preterm birth and low birth weight. Treatment of these conditions with metronidazole during pregnancy may decrease the incidence of preterm birth and low birth weight, thus potentially decreasing the complications that can result from prematurity. Infect. Dis. Obstet. Gynecol. 5:326–335, 1997. © 1998 Wiley‐Liss, Inc.

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“…taneous abortion compared with those prescribed metronidazole 300-180 days prior to delivery; no excess risk was found when the population was compared with women who underwent elective abortion. The authors state that metronidazole therapy is frequently avoided during pregnancy; this may reflect no avoidance of therapy prior to elective abortions, compared with avoidance of Down's syndrome (11) Cardiac defect (11) Hemangioma Anencephaly (stillborn) Beard [25] 2-Hydrocele Congenital hip dislocation Unilateral metatarsus varus Mental retardation (parents also) Robinson, Johnston [42] Polydactyly (familial) Kotcher [21] Crooked foot Zacharias [18] Rh factor (stillborn) Cant6 [30] Midline facial defects (I) therapy in those continuing pregnancy. The manner of presentation of abortion data makes recalculation impossible.…”

Section: Human Studiesmentioning

confidence: 99%