The effect of microgeometry, implant thickness and polyurethane chemistry on the foreign body response to subcutaneous implants

Ward, W. Kenneth; Slobodzian, Emily P; Tiekotter, Kenneth L.; Wood, Michael D.

doi:10.1016/s0142-9612(02)00160-6

Cited by 151 publications

(131 citation statements)

References 25 publications

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“…The major reason for the failure of the implantable biodevice is the occurrence of biofouling, which has been recognized to elicit the rejection reaction and notorious fibrosis 31, 32, 33. While biofouling usually starts with the nonspecific adsorption of proteins to the implanted biomaterial surface 34, 35, 36, 37.…”

Section: Resultsmentioning

confidence: 99%

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Wang

Cui

et al. 2018

Advanced Science

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Recently, there has been a high expectation that high water absorbent hydrogels can be developed as an artificial vitreous body. However, the drawbacks associated with in vivo instability, biofouling, uncontrollable in situ reaction time, and injection‐induced precrosslinked fragmentation preclude their genuine use as vitreous substitutes. Here, a supramolecular binary copolymer hydrogel termed as PNAGA‐PCBAA by copolymerization of N‐acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) is prepared. This PNAGA‐PCBAA hydrogel physically crosslinked by dual amide hydrogen bonds of NAGA exhibits an ultralow solid content (1.6, 98.4 wt% water content), and shear‐thinning behavior, body temperature extrudability/self‐healability, rapid network recoverability, and very close key parameters (modulus, antifouling/antifibrosis, light transmittance, refractive index, ultrastability) to human vitreous body. It is demonstrated that the hydrogel can be readily injected by a 22G needle into the rabbits' eyes where the gelling network is rapidly recovered. After 16 weeks postoperation, the hydrogel acts as a very stable vitreous substitute without affecting the structure of soft tissues in eye, or eliciting adverse effects. This supramolecular binary copolymer hydrogel finds a broad application in ophthalmic fields as not only a self‐recoverable permanent vitreous substitute, but also transient intraocular filling for prevention of inner tissues in postsurgical eyes.

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Section: Resultsmentioning

confidence: 99%

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Wang

Cui

et al. 2018

Advanced Science

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“…It will also minimize implantation tissue damage and hence decrease the foreign body immune reaction. 3 The miniaturization of these functional implants will also permit these devices to achieve their long-term potential for continuous health monitoring.…”

Section: Introductionmentioning

confidence: 99%

Optical power transfer and communication methods for wireless implantable sensing platforms

et al. 2015

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Abstract. Ultrasmall scale implants have recently attracted focus as valuable tools for monitoring both acute and chronic diseases. Semiconductor optical technologies are the key to miniaturizing these devices to the longsought sub-mm scale, which will enable long-term use of these devices for medical applications. This can also enable the use of multiple implantable devices concurrently to form a true body area network of sensors. We demonstrate optical power transfer techniques and methods to effectively harness this power for implantable devices. Furthermore, we also present methods for optical data transfer from such implants. Simultaneous use of these technologies can result in miniaturized sensing platforms that can allow for large-scale use of such systems in real world applications.

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“…Суть последнего состоит в закономер-ной конкурентной динамике обмена (адгезии и диссоциации) плазменных белков на поверхности имплантата в зависимости от их концентрации в плазме крови. Начальная последовательность ад-сорбции следующая: альбумин -иммуноглобу-лин G -фибриноген и фибронектин -фактор XII и высокомолекулярный кининоген [31,55]. При-сутствие в составе провизорного матрикса мито-генов, хемоаттрактантов, цитокинов, факторов роста и других биоактивных соединений опреде-ляет его модулирующий эффект на активность клеточных элементов, в том числе моноци-тов/макрофагов, и характер последующих отгра-ничительных реакций на биоматериалы.…”

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“…W.K. Ward et al [55,56] установили, что подкожная имплантация пори-стых материалов с разным размером пор (поли-виниловые губки, E-PTFE) ведет к активному ан-гиогенезу в сравнении с солидными гладкими мембранами. Из большого количества исследова-ний влияния геометрии структуры биоматериалов на тканевую реакцию можно сделать два основ-ных вывода: 1) большинство клеток лучше связы-ваются с пористыми поверхностями, чем с глад-кими; 2) количество новообразованных капилля-ров больше на поверхности преимущественно пористых и тканных материалов в сравнении с гладкими.…”

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“…W.K. Ward et al [55] при имплантации сенсоров глюкозы, покрытых полиуретаном, вы-явили длительную высокую экспрессию РНК TGF1 и белка в ГКИТ, с наибольшим уровнем на 7-е сутки эксперимента. При этом выявлено нарастающее количество коллагена I типа вокруг имплантатов.…”

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Гигантские Клетки Инородных Тел И Тканевые Реакции На Поверхности Имплантатов

Dolzhikov¹,

Колпаков²,

Ярош³

et al. 2017

Курск. науч.-практ. вестн. «Человек и его здоровье»

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The effect of microgeometry, implant thickness and polyurethane chemistry on the foreign body response to subcutaneous implants

Cited by 151 publications

References 25 publications

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Antifouling Super Water Absorbent Supramolecular Polymer Hydrogel as an Artificial Vitreous Body

Optical power transfer and communication methods for wireless implantable sensing platforms

Гигантские Клетки Инородных Тел И Тканевые Реакции На Поверхности Имплантатов

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