The effect of microgravity on tissue structure and function of rat testis

Ding, Ye; Tang, Jin; Zou, Jun; She, Ruiping; Wang, Yinghua; Zhuo, Yong; Tian, Jianhui; Xia, Kangkang; Yin, Jingdong; Wang, Desheng

doi:10.1590/s0100-879x2011007500147

Cited by 11 publications

(7 citation statements)

References 33 publications

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“…A summary of the key information from these articles is shown in Table 1 . These articles included five studies from Japan (23.8%), four studies from China (19.04%), four studies from Russia (19.04%), three studies from the United States (14.2%), one study from India (4.76%), one study from the United Kingdom (4.76%), one study from Australia (4.76%), one study from Egypt (4.76%), and one study from Spain (4.76%) ( Tash and Bracho, 1999 ; Tash et al, 2002 ; Kamiya et al, 2003 ; Sasaki et al, 2004 ; Ikeuchi et al, 2005 ; Ding et al, 2011 ; Kumar et al, 2013 ; Li et al, 2013 ; Yan et al, 2013 ; Zhou et al, 2016 ; Wakayama et al, 2017 ; Olejnik et al, 2018 ; Usik and Ogneva, 2018 ; Fuller et al, 2019 ; Matsumura et al, 2019 ; Ogneva et al, 2020a ; Boada et al, 2020 ; Ogneva et al, 2020b ; Said et al, 2020 ; Ogneva, 2021 ). Seventeen of the articles conducted the experiment on Earth (fifteen simulations and two occupational exposures), three of the studies performed the experiment on the International Space Station (ISS), and one of the articles conducted experiments during a Space Shuttle mission.…”

Section: Resultsmentioning

confidence: 99%

“…Four articles did not mention the sample size ( Tash et al, 2002 ; Ogneva et al, 2020b ; Said et al, 2020 ; Ogneva, 2021 ), but in the remaining studies, the reported sample sizes ranged between 12 and 560 subjects. Thirteen articles were exclusively performed on microgravity ( Tash and Bracho, 1999 ; Tash et al, 2002 ; Kamiya et al, 2003 ; Sasaki et al, 2004 ; Ikeuchi et al, 2005 ; Ding et al, 2011 ; Masini et al, 2012 ; Usik and Ogneva, 2018 ; Matsumura et al, 2019 ; Ogneva et al, 2020a ; Boada et al, 2020 ; Said et al, 2020 ; Ogneva, 2021 ), while seven articles were performed on ionizing radiation ( Kumar et al, 2013 ; Li et al, 2013 ; Zhou et al, 2016 ; Wakayama et al, 2017 ; Olejnik et al, 2018 ; Fuller et al, 2019 ; Ogneva et al, 2020b ), and only one article conducted combined experiments on both microgravity and ionizing radiation ( Yan et al, 2013 ).…”

Section: Resultsmentioning

confidence: 99%

“…Tail suspension caused severe damage to the seminiferous tubules making the basal lamina appear rough. Ding et al also mentioned that with extended suspension time, the damage to the testes became more serious even reaching irreversibility ( Ding et al, 2011 ). Tash et al who used the tail suspension method to produce a microgravity environment showed a significant reduction in the number of testicular sperm and elongating spermatids accompanied the decline in testicular weight in the tail suspended animals (1.10 ± 0.11 g, p < 0.001) versus the control group (1.70 ± 0.06 g).…”

Section: Discussionmentioning

confidence: 99%

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Effects of space flight on sperm function and integrity: A systematic review

et al. 2022

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With the advancement in space exploration and the intention to establish an inhabitable human settlement on Mars, it is important to investigate the effects of exposure to space/microgravity and the associated radiations on procreation. Sperm function and integrity are fundamental to male reproduction and can potentially be affected by the environmental changes experienced in space. Therefore, this study was conducted to systematically gather, filter, and collate all the relevant information on the effects of spaceflight on male reproductive parameters and functions. A search was performed utilizing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were extracted from the major electronic databases including PubMed, and other credible literature sources. MeSH search terms that were employed included “spermatozoa”, “microgravity”, and “ionizing radiation”. The literature search did not discriminate against papers published before a certain date due to the very limited number of articles available. However, there was a restriction on the male gender and language (English). The parameters included in this study are sperm motility, total sperm count, sperm DNA fragmentation hormonal levels and testicular histology. Following a comprehensive literature search, a total of 273 articles were retrieved and screened, 252 articles were excluded due to the irrelevance to the topic, duplication, and non-original articles. A total of 21 articles met the inclusion criteria and are included in the current study. Findings from these studies showed that sperm motility was decreased after exposure to microgravity and ionizing radiation. Total sperm count was also found to be reduced by microgravity only. Sperm DNA fragmentation was increased by both ionizing radiation and microgravity. Testosterone levels and testicular weight were also decreased by microgravity. Although there is a dearth in the literature regarding the effects of microgravity and ionizing radiation on male reproductive parameters, the available findings showed that exposure to microgravity poses a risk to male reproductive health. Therefore, it is essential to develop countermeasures to either manage, treat, or prevent these consequential adverse effects. Hence, this review also highlights some potential countermeasure approaches that may mitigate the harmful effects of microgravity and associated exposures on male reproductive health.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of space flight on sperm function and integrity: A systematic review

et al. 2022

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“…Rodents subjected to simulated microgravity induce oxidative stress and lipid peroxidation causing damage to brain (Wise et al 2005) liver (Stein et al 2005), testis (Ding et al 2011) and muscle loss (Fitts et al 2000). Liver plays a major role in carbohydrate metabolism and the microgravity environment may have a profound effect, probably altering the regulatory enzyme activities of glycolysis and gluconeogenesis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Simulated Microgravity on the Activity of Regulatory Enzymes of Glycolysis and Gluconeogenesis in Mice Liver

Ramirez

Periyakaruppan

Sarkar

et al. 2014

Microgravity Sci. Technol.

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Gravity supports all the life activities present on earth. Microgravity environments have effect on the biological functions and physiological status of an individual. The present study was undertaken to investigate the effect of simulated microgravity on important regulatory enzymes of carbohydrate metabolism in liver using HLS mice model. Following hind limb unloading of mice for 11 days the animal's average body weights were found to be not different, while the liver weights were decreased and found to be significantly different (p < 0.005) from control mice. Further, in liver the specific activity of hexokinase enzyme was reduced (p < 0.02) and the phosphoenolpyruvate carboxykinase activity was significantly increased in simulated microgravity subjected mice compared to control (p < 0.003). Immunoblot analysis show decreased phosphofructokinase-2 activity in HLS mice compared to control. Liver lactate dehydrogenase activity significantly reduced in simulated microgravity subjected mice (p < 0.005). Thus in our study the rodents have adapted to simulated microgravity

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“…3 In contrast, several studies reported not only degenerative changes in seminiferous tubules and severe irreversible damage to the testicular structure of rodents, but also highlighted diminished sperm parameters (e.g., concentration, motility, progressive motility) under conditions of real and simulated microgravity. [4][5][6] Furthermore, a decrease in testosterone levels were observed in rats that were onboard COS-MOS 2044 or subjected to hindlimb suspension as a model for mimicking microgravity conditions. 7,8 Thyroid and testicular functions of mice, that spent 91 days onboard the ISS, were also affected.…”

mentioning

confidence: 99%

Human spaceflight: to infertility and beyond

Maya

Plessis

2019

Int J Reprod Contracept Obstet Gynecol

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Garrett-Bakelman FE et al, demonstrated a spectrum of molecular and physiological changes attributed to spaceflight in their recently published “NASA Twins Study”.1 During his 340 days in space onboard the International Space Station (ISS), one of a pair of monozygotic twins was not only challenged by noise, isolation, hypoxia, and alterations in the circadian rhythm, but more importantly the exposure to ionizing radiation (IR) and microgravity. Terrestrials are subjected constantly to surface gravity and most if not all physiological processes have adapted accordingly. It is therefore easy to envisage that weightlessness can have consequences for space travellers.2

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The effect of microgravity on tissue structure and function of rat testis

Cited by 11 publications

References 33 publications

Effects of space flight on sperm function and integrity: A systematic review

Effects of space flight on sperm function and integrity: A systematic review

Effect of Simulated Microgravity on the Activity of Regulatory Enzymes of Glycolysis and Gluconeogenesis in Mice Liver

Human spaceflight: to infertility and beyond

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