The Effect of Microneedle Thickness on Pain During Minimally Invasive Facial Procedures: A Clinical Study

Sezgin, Billur; Özel, Begüm; Bulam, Hakan; Güney, Kırdar; Tuncer, Serhan; Çenetoğlu, Seyhan

doi:10.1177/1090820x14532941

Cited by 30 publications

(19 citation statements)

References 19 publications

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“…A narrower gauge needle (33-G) was found to be more acceptable than a larger gauge (30-G). 70,71 Small syringes with graduated markings are recommended to facilitate the division of the total dose into several injections. Ascher et al recommend the use of needles marked into thirds along their length to allow the clinician to judge how deep the injection has been placed.…”

Section: The Influence Of Technique On Abo Efficacymentioning

confidence: 99%

Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration

Nestor

Ablon

Pickett

2017

Aesthetic Surgery Journal

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Time to onset of response and duration of response are key measures of botulinum toxin efficacy that have a considerable influence on patient satisfaction with aesthetic treatment. However, there is no overall accepted definition of efficacy for aesthetic uses of botulinumtoxinA (BoNT-A). Mechanical methods of assessment do not lend themselves to clinical practice and clinicians rely instead on assessment scales such as the Frontalis Activity Measurement Standard, Frontalis Rating Scale, Wrinkle Severity Scale, and Subject Global Assessment Scale, but not all of these have been fully validated. Onset of activity is typically seen within 5 days of injection, but has also been recorded within 12 hours with abobotulinumtoxinA. Duration of effect is more variable, and is influenced by parameters such as muscle mass (including the effects of age and sex) and type of product used. Even when larger muscles are treated with higher doses of BoNT-A, the duration of effect is still shorter than that for smaller muscles. Muscle injection technique, including dilution of the toxin, the volume of solution injected, and the positioning of the injections, can also have an important influence on onset and duration of activity. Comparison of the efficacy of different forms of BoNT-A must be made with the full understanding that the dosing units are not equivalent. Range of equivalence studies for abobotulinumtoxinA (Azzalure; Ipsen Limited, Slough UK/Galderma, Lausanne CH/Dysport, Ipsen Biopharm Limited, Wrexham UK/Galderma LP, Fort Worth, TX) and onabotulinumtoxinA (Botox; Allergan, Parsippany, NJ) have been conducted, and results indicate that the number of units of abobotulinumtoxinA needs to be approximately twice as high as that of onabotulinumtoxinA to achieve the same effect. An appreciation of the potential influence of all of the parameters that influence onset and duration of activity of BoNT-A, along with a thorough understanding of the anatomy of the face and potency of doses, are essential to tailoring treatment to individual patient needs and expectations.

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Section: The Influence Of Technique On Abo Efficacymentioning

confidence: 99%

Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration

Nestor

Ablon

Pickett

2017

Aesthetic Surgery Journal

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“…To minimize patient discomfort, ice packs and/or topical anesthetics can be placed on the planned injection site, and the smallest possible gauge needle is used. 8 Diffusion of BoNT from the injection site can occur and must be accounted for when determining injection sites. Depending on the desired effects, the concentration of BoNT can be varied to precisely treat specific muscle groups without increasing the area of diffusion.…”

Section: General Injection Guidelines and Techniquesmentioning

confidence: 99%

“…In patients with total paralysis without synkinesis, BoNT can be used on the nonparalyzed side to treat the apparent hyperkinesis (►Figs. 8,9). Meanwhile, in patients with partial recovery, BoNT can be used to treat the synkinesis on the affected side and compensatory hyperkinesis on the nonparlyzed side.…”

Section: Facial Paralysismentioning

confidence: 99%

Neurotoxins

Ong

Sherris

2019

Facial plast Surg

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Botulinum toxin is integral to the practice of facial plastic surgery. Since it was approved by the U.S. Food and Drug Administration for the temporary improvement of glabellar rhytids in 2002, botulinum toxin has achieved a growing number of off-label clinical applications. These include the management of facial rhytids, brow ptosis, excessive gingival display, masseteric hypertrophy, platysmal banding, facial nerve paralysis, hypertrophic scars, and keloids. Many forms of botulinum toxin have been developed, and their safety and efficacy have been thoroughly established. This article will review the aesthetic and functional uses of botulinum toxin as it relates to the field of facial plastic and reconstructive surgery. In addition, the authors will discuss the suggested quantity of units per injection site based on onabotulinumtoxinA.

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“…corrugatores optimal behandelt werden können). Aus kleineren Studien gibt es Hinweise, dass die Verwendung von konservierter Kochsalzlösung (Bacteriostatic 0,9 % Sodium Chloride, Abbott Laboratories, North Chicago, IL 60064, USA) [11] und kleinere Nadeln (33 G statt 30 G) die Schmerzhaftigkeit weiter vermindern [12].…”

Section: Vorgelöste Toxineunclassified

Botulinumtoxin A – was gibt es Neues?

Rzany¹

2017

Akt Dermatol

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ZusammenfassungNach über 20 Jahren Anwendung von Botulinumtoxin A in der Ästhetischen Medizin gibt es wenig neue Herausforderungen. Die Standardindikationen, die Standardinjektionspunkte und die Dosierungen sind klar und ermöglichen eine wirksame und sichere Behandlung unserer Patienten. Um die Behandlungszufriedenheit kontinuierlich zu verbessern, müssen individuelle Wünsche und die jeweilige anatomische Konstellation im Injektionsplan berücksichtig werden. Mit jedem neuen Patienten wachsen unsere Erfahrungen. Wir sehen mehr, verstehen mehr und lernen unsere Patienten besser zu behandeln. Mit den neuen Toxinen aus Asien und den vorverdünnten Toxinen wird sich der Markt für Botulinumtoxine in den nächsten Jahren beleben. Die Behandlungen mit Botulinumtoxin werden mit großer Wahrscheinlichkeit durch das vermehrte Angebot der Botulinumtoxine günstiger für unsere Patienten werden.

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The Effect of Microneedle Thickness on Pain During Minimally Invasive Facial Procedures: A Clinical Study

Abstract: 3.

Cited by 30 publications

References 19 publications

Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration

Key Parameters for the Use of AbobotulinumtoxinA in Aesthetics: Onset and Duration

Neurotoxins

Botulinumtoxin A – was gibt es Neues?

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