The effect of micronutrient supplementation on serum anti-Mullerian hormone levels: a retrospective pilot study

Lipovac, Markus; Aschauer, Judith; Imhof, Hannah; Herrmann, Clara; Sima, M.; Weiss, P; Imhof, Martin

doi:10.1080/09513590.2022.2028770

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…Additionally, fatty acid levels have been found to impact menopausal symptoms [63]. Previous research supports the administration of omega-3 fatty acids to increase ovarian reserve [64], by potentially delaying the onset of menopause. Our main and replication MR analyses, pathway analysis, and observational study in ALSPAC converge to a delaying effect of omega-3, polyunsaturated, and monounsaturated fatty acids, on age at menopause, suggesting a protective role of polyunsaturated and omega-3 fatty acid supplementation in women at risk of premature menopause.…”

Section: Discussionmentioning

confidence: 93%

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

Yazdanpanah,

Gamache

et al. 2024

Genome Med

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Background The role of metabolism in the variation of age at menarche (AAM) and age at natural menopause (ANM) in the female population is not entirely known. We aimed to investigate the causal role of circulating metabolites in AAM and ANM using Mendelian randomization (MR). Methods We combined MR with genetic colocalization to investigate potential causal associations between 658 metabolites and AAM and between 684 metabolites and ANM. We extracted genetic instruments for our exposures from four genome-wide association studies (GWAS) on circulating metabolites and queried the effects of these variants on the outcomes in two large GWAS from the ReproGen consortium. Additionally, we assessed the mediating role of the body mass index (BMI) in these associations, identified metabolic pathways implicated in AAM and ANM, and sought validation for selected metabolites in the Avon Longitudinal Study of Parents and Children (ALSPAC). Results Our analysis identified 10 candidate metabolites for AAM, but none of them colocalized with AAM. For ANM, 76 metabolites were prioritized (FDR-adjusted MR P-value ≤ 0.05), with 17 colocalizing, primarily in the glycerophosphocholines class, including the omega-3 fatty acid and phosphatidylcholine (PC) categories. Pathway analyses and validation in ALSPAC mothers also highlighted the role of omega and polyunsaturated fatty acids levels in delaying age at menopause. Conclusions Our study suggests that metabolites from the glycerophosphocholine and fatty acid families play a causal role in the timing of both menarche and menopause. This underscores the significance of specific metabolic pathways in the biology of female reproductive longevity.

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Section: Discussionmentioning

confidence: 93%

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

Yazdanpanah,

Gamache

et al. 2024

Genome Med

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Preconceptional micronutrient supplementation and spontaneous pregnancy rates in women of higher reproductive age and unexplained infertility: A comparative study

Aschauer,

Halát,

Imhof

2024

Clínica e Investigación en Ginecología y Obstetricia

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Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats

Rezaei Moghadam,

Khoshrou,

Kakhki

et al. 2023

Nicotine and Tobacco Research

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Abstracts Introduction The present study aimed to assess the efficacy of folic acid (FA) on withdrawal following nicotine (Nic) administration in adolescent male rats. Methods Adolescent male rats were divided into two groups: 1) vehicle and 2)Nic (Nic-2mg/kg), and were under the treatment from 21 to 42 days of age. After that, they continued the experiment without treatment and returned to a regular diet, except for one of those who received Nic. The rats were divided into four groups where they were treated with different doses of FA (5, 10, and 15 mg/kg) and bupropion (Bup) by oral gavage, and the final group included normal rats that received only FA (15mg/kg) from 42 days of age for three weeks during which withdrawal occurred. Results Results showed that adolescent Nic exposure exacerbated the behavioral indices of anxiety- and depression-like behaviors, while FA attenuated the effects of Nic withdrawal on anxiety and depression as well as Bup. In support, the biochemical results demonstrated a balance between oxidant and antioxidant mediators in addition to increase and decrease of serotonin and monoamine oxidase (MAO) activity in cortical tissue. TNF-α as an inflammatory agent was decreased, whereas IL-10 as an anti-inflammatory parameter was increased. Conclusion The present findings suggest anxiety and depression caused by Nic withdrawal were attenuated by FA more likely through reduction activity of MAO, the important enzyme responsible for serotonin metabolism along with balance between oxidant/anti-oxidant and pro-inflammatory/anti-inflammatory mediators. However, various mechanisms might be involved, which requires further investigation. Implications Nic withdrawal induced depression and anxiety like behavior in rats followed by neuro-oxidative damage and neuro-inflammation. Folic acid supplementation as well as bupropion improved cognitive disorders induced by Nic withdrawal by increasing neuro-inflammation, neuro-oxidative damage.

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The effect of micronutrient supplementation on serum anti-Mullerian hormone levels: a retrospective pilot study

Cited by 5 publications

References 28 publications

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause

Preconceptional micronutrient supplementation and spontaneous pregnancy rates in women of higher reproductive age and unexplained infertility: A comparative study

Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats

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