The Effect of Mild Exercise in the Supine Position on the Pulmonary Arterial Pressure of Five Normal Human Subjects 1

Slonim, N. Balfour; Ravin, Abe; Balchum, Oscar J.; Dressler, Sidney H.

doi:10.1172/jci102969

Cited by 66 publications

(22 citation statements)

References 10 publications

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“…1) [8][9][10][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. After the exclusion of individuals with prospectively defined implausible data, 222 subjects (147 males, 33 females, 42 sex not available) were analysed.…”

Section: Resultsmentioning

confidence: 99%

Pulmonary vascular resistances during exercise in normal subjects: a systematic review

Kovàcs

Olschewski²,

Berghold³

et al. 2011

Eur Respir J

210

161

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The physiological range of pulmonary vascular resistance (PVR) and total pulmonary resistance (TPR), and the impact of exercise, age and posture have been a matter of debate for many years.We performed a systematic literature review including all right heart catheterisation data where individual PVR and TPR of healthy subjects both at rest and exercise were available. Data were stratified according to age, exercise level and posture.Supine resting PVR in subjects aged ,24 yrs, 24-50 yrs, 51-69 yrs and o70 yrs was 61¡23, 69¡28, 86¡15 and 90¡39 dyn?s?cm -5 , respectively. Corresponding TPR was 165¡50, 164¡46, 226¡64 and 223¡45 dyn?s?cm -5, respectively. During moderate exercise in subjects aged f50 yrs, an 85% increase in cardiac output was associated with a 25% decrease in TPR (p,0.0001) and a 12% decrease in PVR (p,0.01). At 51-69 yrs of age there was no significant decrease in TPR and PVR. In individuals aged o70 yrs TPR even increased by 17% (p50.01), while PVR did not change significantly. At higher exercise levels, TPR decreased in all age groups. In the upright position, based on a limited number of data, resting TPR and PVR were higher than in the supine position and decreased more prominently during exercise, suggesting the release of resting pulmonary vasoconstriction.These data may form a basis to define normal PVR at rest and exercise.

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Section: Resultsmentioning

confidence: 99%

Pulmonary vascular resistances during exercise in normal subjects: a systematic review

Kovàcs

Olschewski²,

Berghold³

et al. 2011

Eur Respir J

210

161

View full text Add to dashboard Cite

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“…These are shown in Table II (Riley et al, 1948;Hickam and Cargill, 1948;Dexter et al, 1951;Lewis et al, 1952;Slonim et al, 1954;Donald et al, 1955;Freedman et al, 1955;Barratt-Boyes and Wood, 1957).…”

Section: Resultsmentioning

confidence: 99%

Ventilation and haemodynamics in heart disease.

Gazetopoulos¹,

Davies²,

Oliver³

et al. 1966

Heart

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“…Influence of sex, geographical origin, exercise method and position on Ppa Sex and the geographical origin of the data did not significantly influence resting and exercise P pa values (online data supplement, tables G-I) [13,14,16,18,19,29,35,39,43,47].…”

Section: Pulmonary Arterial Pressure During Exercisementioning

confidence: 98%

Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review

Kovàcs

Berghold²,

Scheidl³

et al. 2009

Eur Respir J

905

639

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According to current guidelines, pulmonary arterial hypertension (PAH) is diagnosed when mean pulmonary arterial pressure (Ppa) exceeds 25 mmHg at rest or 30 mmHg during exercise. Issues that remain unclear are the classification of Ppa values ,25mmHg and whether Ppa .30 mmHg during exercise is always pathological.We performed a comprehensive literature review and analysed all accessible data obtained by right heart catheter studies from healthy individuals to determine normal Ppa at rest and during exercise. Data on 1,187 individuals from 47 studies in 13 countries were included. Data were stratified for sex, age, geographical origin, body position and exercise level.Ppa at rest was 14.0¡3.3 mmHg and this value was independent of sex and ethnicity. Resting Ppa was slightly influenced by posture (supine 14.0¡3.3 mmHg, upright 13.6¡3.1 mmHg) and age (,30 yrs: 12.8¡ 3.1mmHg; 30-50 yrs: 12.9¡3.0 mmHg; o50 yrs: 14.7¡4.0 mmHg). Ppa during exercise was dependent on exercise level and age. During mild exercise, Ppa was 19.4¡4.8 mmHg in subjects aged ,50 yrs compared with 29.4¡8.4 mmHg in subjects o50 yrs (p,0.001).In conclusion, while Ppa at rest is virtually independent of age and rarely exceeds 20 mmHg, exercise Ppa is age-related and frequently exceeds 30 mmHg, especially in elderly individuals, which makes it difficult to define normal Ppa values during exercise.

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The Effect of Mild Exercise in the Supine Position on the Pulmonary Arterial Pressure of Five Normal Human Subjects 1

Cited by 66 publications

References 10 publications

Pulmonary vascular resistances during exercise in normal subjects: a systematic review

Pulmonary vascular resistances during exercise in normal subjects: a systematic review

Ventilation and haemodynamics in heart disease.

Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review

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