The effect of mild temperature hyperthermia on tumour hypoxia and blood perfusion: relevance for radiotherapy, vascular targeting and imaging

Sun, Xuejun; Xing, Ligang; Ling, C. Clifton; Li, Gloria C.

doi:10.3109/02656730903479855

Cited by 58 publications

(39 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three synergistic mechanisms have been identified: (1) Inhibition of DNA damage repair: HT enhances the effectiveness of radiotherapy by inhibiting repair of DNA damage [9][10][11], (2) Direct cell killing: HT selectively kills radioresistant hypoxic tumour cells [11][12][13][14], (3) Reoxygenation: HT increases tissue perfusion resulting in reoxygenation, thereby reducing hypoxia and increasing radiosensitivity [15][16][17][18][19]24,25].…”

Section: Synergistic Mechanisms Of Hyperthermiamentioning

confidence: 99%

“…Ideally all three mechanisms of radiosensitisation by hyperthermia suggested in the literature should be modelled: inhibition of DNA damage repair [9][10][11], direct cell killing of radioresistant hypoxic tumour cells [11][12][13][14] and reoxygenation by increased tissue perfusion [15][16][17][18][19]. The contribution of each of these mechanisms to radiosensitisation is still a subject of debate and due to this complicated mix of synergistic effects the optimal treatment scheme for combined radiotherapy and hyperthermia is difficult to determine based on the present literature.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thermoradiotherapy planning: Integration in routine clinical practice

Crezee

Leeuwen

Oei

et al. 2015

International Journal of Hyperthermia

View full text Add to dashboard Cite

Planning of combined radiotherapy and hyperthermia treatments should be performed taking the synergistic action between the two modalities into account. This work evaluates the available experimental data on cytotoxicity of combined radiotherapy and hyperthermia treatment and the requirements for integration of hyperthermia and radiotherapy treatment planning into a single planning platform. The underlying synergistic mechanisms of hyperthermia include inhibiting DNA repair, selective killing of radioresistant hypoxic tumour tissue and increased radiosensitivity by enhanced tissue perfusion. Each of these mechanisms displays different dose-effect relations, different optimal time intervals and different optimal sequences between radiotherapy and hyperthermia. Radiosensitisation can be modelled using the linear-quadratic (LQ) model to account for DNA repair inhibition by hyperthermia. In a recent study, an LQ model-based thermoradiotherapy planning (TRTP) system was used to demonstrate that dose escalation by hyperthermia is equivalent to $10 Gy for prostate cancer patients treated with radiotherapy. The first step for more reliable TRTP is further expansion of the data set of LQ parameters for normally oxygenated normal and tumour tissue valid over the temperature range used clinically and for the relevant time intervals between radiotherapy and hyperthermia. The next step is to model the effect of hyperthermia in hypoxic tumour cells including the physiological response to hyperthermia and the resulting reoxygenation. Thermoradiotherapy planning is feasible and a necessity for an optimal clinical application of hyperthermia combined with radiotherapy in individual patients.

show abstract

Section: Synergistic Mechanisms Of Hyperthermiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermoradiotherapy planning: Integration in routine clinical practice

Crezee

Leeuwen

Oei

et al. 2015

International Journal of Hyperthermia

View full text Add to dashboard Cite

show abstract

“…One of the first demonstrations of hyperthermia is vasodilation, which leads to an increase in blood supply to the tumor [60]. This effect enhances the tumor microenvironment for the action of the immune system by improving oxygenation and reducing acidosis [61]. The vasodilation effect is produced with temperature up until about 43°C, above which perfusion will decrease because of vascular collapse; this affects reoxygenation and drug delivery, complicating the empirical formulation of a thermal dose.…”

Section: Vascular Effects Of Hyperthermiamentioning

confidence: 99%

Intravesical Chemohyperthermia for NMIBC: Rationale and Results of This Developing Treatment

Alejandro¹,

Javier²,

Daniel³

et al. 2017

Bladder Cancer - Management of NMI and Muscle-Invasive Cancer

View full text Add to dashboard Cite

Bladder cancer is the fourth most common cancer in men, and the lifetime risk of getting bladder cancer is 2.4%. Approximately 75% of newly diagnosed cases of bladder cancer are non-muscle-invasive bladder cancer (NMIBC), and half of them will show recurrence and/or progression after transurethral resection. Therefore, after transurethral resection, in high-risk patients, intravesical therapy is mandatory. However, bacillus CalmetteGuérin (BCG) is associated with important side effects such as systemic tuberculosis and bladder retraction. Chemohyperthermia (CHT) has shown a 60% lower recurrence rate than standard mitomycin C (MMC). However, its effectiveness in high-risk patients, especially CIS and BCG refractory patients, is even more important. CHT will probably be an option for patients unsuitable for radical cystectomy or those on whom BCG can't be used. Two main technologies are currently available for intravesical CHT: microwaves and recirculating heated fluids. Both of them have pros and cons that should be known and evaluated by a urologist. In this chapter, we will speak about rationale, technical options, clinical results, ongoing studies, and future perspective for this interesting treatment option for intermediate and high-risk patients with NMIBC.Keywords: NMIBC, MMC, BCG, chemohyperthermia, radio frequency, recirculant systems, adjuvant, neoadjuvant BackgroundIn 2002, the world-adjusted incidence rate of bladder cancer was 33 new cases/100,000 inhabitants/year. That makes it the fourth tumor with the highest incidence in men, after lung, prostate, and colorectal cancers [1].© 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Each body tumor has unique characteristics in terms of its presentation, histological types, surgical approaches, and sensitivity to different types of treatment (surgery, chemotherapy,Approximately, 95% of bladder neoplasms are urothelial carcinomas, and 75% of them will be diagnosed as non-muscle-invasive tumors. However, they have a high tendency to recur, and one-third of them will reappear during the first 5 years after transurethral resection. Incidence of recurrence and progression is directly related to the tumoral grade and stage, being higher in carcinoma in situ and T1G3 tumors.Most recidives have similar grade and stage to the original tumor. However, a significant number of bladder cancers progress to invasive tumors whose prognosis and treatment are completely different. Therefore, intravesical postoperative therapy is mandatory, especially in those with medium and high-risk tumors.The urethra allows ease of access from the outside, which generally allows a resection of the tumor and the application of chemo-and/or immunotherapy locally with minimal systemic toxicity.Intravesical chemotherapy, with single postoperat...

show abstract

“…The cells' radiosensitivity is subjected to many factors, such as the hypoxia [1], temperature [2], concentration of NO [3]. In the investigation of possible factors influencing radiosensitivity, previous studies mainly focused on the process of apoptosis and DNA-repair [4].…”

Section: Introductionmentioning

confidence: 99%

Short-Term Hyperosmolality Pretreatment on Cells Can Reduce the Radiosensitivity via RVI and Akt1 Activation

Liu

Huang²,

Zhang³

et al. 2013

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: The ionizing radiation (IR) has been applied in clinical treatment for many years and the radiosensitivity is crucial to the treatment. Radiosensitivity of cells is subjected to many environmental factors, such as hypoxia and temperature. Hyperosmolality as a common environmental factor has been demonstrated to be associated with survival and apoptosis of cells in many studies. Thus we investigated the influence of hyperosmolality on cells radiosensitivity. Methods: We examined the viability and surviving fraction of L-O2 cells of irradiated L-O2 cells, and detected the effect on AHH-1 cells by flow cytometry, in order to investigate the effect of short-term hyperosmolality pretreatment on cells radiosensitivity. Comet assay was used to assess the DNA strand breaks. Then the detection of Akt1 by western blot and the process of regulatory volume increase by CYSY-TT were involved in the mechanism. Result: We demonstrated that a short-term hyperosmolality pretreatment on cells could reduce their radiosensitivity. Further research indicated that the short-term hypertonic condition could induce regulatory volume increase (RVI), which activated Akt1 and degenerated the IκB-α. This process was associated with reduced cells radiosensitivity. Finally, we used the flufenamic acid (FFA), a blocker to cation channels (HICCs) to inhabit RVI and consequently inhabit the protective effect of hyperosmolality on irradiated cells. Conclusion: a short-term hyperosmolality pretreatment could reduce the cells radiosensitivity by RVI and following activation of Akt1.

show abstract

The effect of mild temperature hyperthermia on tumour hypoxia and blood perfusion: relevance for radiotherapy, vascular targeting and imaging

Cited by 58 publications

References 26 publications

Thermoradiotherapy planning: Integration in routine clinical practice

Thermoradiotherapy planning: Integration in routine clinical practice

Intravesical Chemohyperthermia for NMIBC: Rationale and Results of This Developing Treatment

Short-Term Hyperosmolality Pretreatment on Cells Can Reduce the Radiosensitivity via RVI and Akt1 Activation

Contact Info

Product

Resources

About