The effect of mild therapeutic hypothermia on good neurological recovery after out-of-hospital cardiac arrest according to location of return of spontaneous circulation: A nationwide observational study

Bae, Kwang Soo; Shin, Sang Do; Ro, Young Sun; Song, Kyoung Jun; Lee, Eui Jung; Lee, Yu Jin; Suh, Gil Joon; Kwak, Young Ho

doi:10.1016/j.resuscitation.2015.01.024

Cited by 16 publications

(8 citation statements)

References 32 publications

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“…In an observational study of 11,158 patients admitted to hospital after OHCA in Korea, those treated with mild therapeutic hypothermia achieved a better neurological outcome than those who were not cooled. 74 After analysis using multivariable logistic regression, mild hypothermia was associated with better outcome for those patients achieving ROSC in the emergency department but not for those who achieved ROSC prehospital.…”

Section: Targeted Temperature Managementmentioning

confidence: 93%

Resuscitation highlights in 2015

et al. 2016

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Section: Targeted Temperature Managementmentioning

confidence: 93%

Resuscitation highlights in 2015

et al. 2016

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“…Neurological damage after resuscitation in out-of-hospital cardiac arrest (OHCA) patients induced poor outcomes or death [1]. Much effort has been made to reduce neurological damage in OHCA patients, of which targeted temperature management (TTM) has been shown to be excellent in reducing neurological damage in post-resuscitation treatment [2,3]. Although the exact mechanism of TTM is still unclear, previous studies have speculated that it works through the modes of inhibiting ischemia-reperfusion inju-ry, mitigating intracranial hypertension, reducing brain edema, and stimulating the protective system [4,5].…”

Section: Association Between Initial Body Temperature and Neurologic Outcomes Of Out-of-hospital Cardiac Arrest Patients Undergoing Targementioning

confidence: 99%

Association between initial body temperature and neurologic outcomes of out-of-hospital cardiac arrest patients undergoing targeted temperature management

Kim

Park

et al. 2021

J EMS Med

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Objective: Targeted temperature management (TTM) is the core post-resuscitation treatment to minimize neurologic deficit after out-of-hospital cardiac arrest (OHCA). Abnormal initial body temperature (BT) can be associated with neurologic damage during the arrest. We aimed to investigate the association between initial BT and neurologic outcomes of OHCA patients who underwent TTM. Methods: This study used a nationwide OHCA database from January 2013 to December 2018. Among OHCA patients with cardiac etiology over 18 years of age, patients with TTM treatment were included. BT at the initiation of TTM was categorized into three groups: low (35.5°C), normal (35.6°C−37.4°C), and high (37.5°C). The primary outcome was a good neurologic recovery (Cerebral Performance Categories 1 or 2). The association between initial BT and outcome was assessed using multivariable logistic regression analysis. Results: One thousand two hundred and twenty-six patients were analyzed, 354 (28.9%), 767 (62.6%), and 105 (8.6%) were in the low, normal, and high BT groups, respectively. Good neurologic recovery rate was 15.0%, 39.9%, and 34.3% respectively. The aOR for good neurologic recovery was 0.36 (95% confidence interval [CI], 0.25 to 0.51) in the low and 0.72 (95% CI, 0.43 to 1.22) in the high BT group compared with the normal BT group. Conclusion: Low BT at the initiation of TTM was associated with unfavorable neurologic recovery for OHCA patients who underwent TTM.

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“…Neurological damage after resuscitation in out-of-hospital cardiac arrest (OHCA) patients induced poor outcomes or death [1]. Much effort has been made to reduce neurological damage in OHCA patients, of which targeted temperature management (TTM) has been shown to be excellent in reducing neurological damage in post-resuscitation treatment [2,3]. Although the exact mechanism of TTM is still unclear, previous studies have speculated that it works through the modes of inhibiting ischemia-reperfusion injury, mitigating intracranial hypertension, reducing brain edema, and stimulating the protective system [4,5].…”

Section: Introductionmentioning

confidence: 99%

Association between initial body temperature and neurologic outcomes of out-of-hospital cardiac arrest patients undergoing targeted temperature management

Kim

Park

et al. 2023

J EMS Med

Self Cite

View full text Add to dashboard Cite

Objective: Targeted temperature management (TTM) is the core post-resuscitation treatment to minimize neurologic deficit after out-of-hospital cardiac arrest (OHCA). Abnormal initial body temperature (BT) can be associated with neurologic damage during arrest. We aimed to investigate the association between initial BT and neurologic outcomes of OHCA patients who underwent TTM. Methods: This study used a nationwide OHCA database from January 2013 to December 2018. Among OHCA patients older than 18 years and with cardiac etiology, those with TTM treatment were included. BT at the initiation of TTM was categorized into three groups: low (35.5°C), normal (35.6°C−37.4°C), and high (37.5°C). The primary outcome was good neurologic recovery (Cerebral Performance Category 1 or 2). The association between initial BT and outcome was assessed using multivariable logistic regression analysis. Results: A total of 1226 patients were analyzed, 354 (28.9%), 767 (62.6%), and 105 (8.6%) in the low, normal, and high BT groups, respectively. The good neurologic recovery rate was 15.0%, 39.9%, and 34.3% in these respective groups. The aOR for good neurologic recovery was 0.36 (95% confidence interval [CI], 0.25 to 0.51) in the low and 0.72 (95% CI, 0.43 to 1.22) in the high BT group compared with the normal BT group. Conclusion: Low BT at the initiation of TTM was associated with unfavorable neurologic recovery for OHCA patients who underwent TTM.

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The effect of mild therapeutic hypothermia on good neurological recovery after out-of-hospital cardiac arrest according to location of return of spontaneous circulation: A nationwide observational study

Cited by 16 publications

References 32 publications

Resuscitation highlights in 2015

Resuscitation highlights in 2015

Association between initial body temperature and neurologic outcomes of out-of-hospital cardiac arrest patients undergoing targeted temperature management

Association between initial body temperature and neurologic outcomes of out-of-hospital cardiac arrest patients undergoing targeted temperature management

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