The Effect of Mineralocorticoid and Glucocorticoid Receptor Antagonism on Autobiographical Memory Recall and Amygdala Response to Implicit Emotional Stimuli

Young, Kymberly; Preskorn, Sheldon; Victor, Teresa A.; Misaki, Masaya; Bodurka, Jerzy; Drevets, Wayne C.

doi:10.1093/ijnp/pyw036

Cited by 13 publications

(20 citation statements)

References 53 publications

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“…Previous neuroimaging experiments have provided evidence that high levels of exogenous GCs, mimicking stress-associated states, alter both the neural processing in response to emotional or cognitive stimulation and the resting state functional connectivity (7)(8)(9)(10)(11)(12)(13)(14). These studies suggest a specific role for MRs in some of these stress-related changes in both neural processing and functional connectivity (15,16), while MR or GC receptor antagonism impacts the amygdala-dependent processing of emotional faces (77). Our study findings now provide evidence that even in the absence of a stressful stimulus, the ultradian GC rhythm is critical in regulating neural dynamics and, consequently, behavioral and cognitive phenotypes.…”

Section: Discussionmentioning

confidence: 95%

Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

Kalafatakis

Russell

Harmer

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

104

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Glucocorticoids (GCs) are secreted in an ultradian, pulsatile pattern that emerges from delays in the feedforward-feedback interaction between the anterior pituitary and adrenal glands. Dynamic oscillations of GCs are critical for normal cognitive and metabolic function in the rat and have been shown to modulate the pattern of GC-sensitive gene expression, modify synaptic activity, and maintain stress responsiveness. In man, current cortisol replacement therapy does not reproduce physiological hormone pulses and is associated with psychopathological symptoms, especially apathy and attenuated motivation in engaging with daily activities. In this work, we tested the hypothesis that the pattern of GC dynamics in the brain is of crucial importance for regulating cognitive and behavioral processes. We provide evidence that exactly the same dose of cortisol administered in different patterns alters the neural processing underlying the response to emotional stimulation, the accuracy in recognition and attentional bias toward/away from emotional faces, the quality of sleep, and the working memory performance of healthy male volunteers. These data indicate that the pattern of the GC rhythm differentially impacts human cognition and behavior under physiological, nonstressful conditions and has major implications for the improvement of cortisol replacement therapy.

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Section: Discussionmentioning

confidence: 95%

Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

Kalafatakis

Russell

Harmer

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

104

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“…These differential effects may be explained by differences in basal cortisol between different groups and also between people within a diagnostic group, as well as individual differences in the reception of cortisol within the brain, particularly in areas of the brain such as the hippocampus [37]. Indeed, administration of a glucocorticoid receptor antagonist to healthy participants, thereby reducing the occupation of these receptors by cortisol, has been found to lead to significant improvements in specificity relative to a placebo [69]. No study has yet examined the neural mechanism by which cortisol influences specific memory retrieval.…”

Section: The Neuroendocrinology Of Memory Specificitymentioning

confidence: 99%

The Neurobiology of Reduced Autobiographical Memory Specificity

Barry

Chiu

Raes

et al. 2018

Trends in Cognitive Sciences

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There has been a recent growth in investigations into the neural mechanisms underlying the problems recalling specific autobiographical events that are a core feature of emotional disorders. In this review we provide the first synthesis of this literature, taking into account brain as well as cognitive mechanisms. We suggest that these problems are driven by idiosyncratic activation in areas of the brain associated with assigning salience and self-relevance to emotional memories. Other areas associated with inhibiting distraction and constructing vivid memory representations are also important. Each of these mechanisms may work independently or in concert with one another. Importantly, this interaction between mechanisms may differ between diagnostic and demographic groups such that similar problems in specificity may be characterised by different mechanisms. Given this challenge, neuroimaging may prove useful in identifying patient-specific biomarkers for interventions. Autobiographical Memory SpecificityAutobiographical memories (AMs), defined as memories for personally experienced past events, offer examples of who we are and of failures and successes to be avoided or replicated. Some people, however, exhibit difficulty recalling specific events from their past (e.g., an occasion where they ate dinner with friends). When asked to retrieve a memory related to a cue (e.g., friend), they might instead retrieve general information (e.g., the idea of what a friend is). This tendency for reduced autobiographical memory specificity (rAMS) is one of the core cognitive mechanisms associated with emotional disorders such as depression [1-6] (Box 1 and Figure 1). rAMS is also a cognitive mechanism for which targeted interventions exist, and its amelioration through these interventions has been found to lead to an improvement in disorder symptoms [7][8][9][10]. Neuroscience research has begun to elucidate the neurobiology of specific autobiographical memory retrieval and its role amongst clinical groups who have difficulty retrieving specific memories. We provide the first synthesis of this literature. This review examines what we know about the neurobiology of autobiographical memory and memory specificity in particular. We consider what this means for why rAMS occurs and its role in emotional disorders, contrasting this neuroscience evidence with cognitive models of rAMS. We also consider what these advances in neuroscience mean for interventions seeking to improve memory specificity or to treat emotional disorders. The Biological Architecture of Autobiographical MemoryResearchers have identified a network of brain regions across the prefrontal cortex, medial temporal lobe (MTL), limbic system, and occipital lobe that is associated with the retrieval (see Glossary) and re-experiencing of AMs, irrespective of their specificity [11][12][13], but which might be differentially activated as a function of specificity (Figure 2, Key Figure). In particular, activity in lateral portions of the prefrontal cortex (PFC) has been as...

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“…Although earlier studies found no relation between MR functioning and perspective taking (Wingenfeld et al 2014 ), or even diminished perspective taking (Wingenfeld et al 2016 ), higher MR functioning after pharmacological stimulation resulted in enhanced empathic concern (Wingenfeld et al 2014 ) in clinically depressed adults. Moreover, in healthy subjects increased emotion processing has been reported after pharmacological stimulation (Schultebraucks et al 2016 ), and diminished emotion processing after pharmacological inhibition of MR functioning (Young et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Stressful Parenting and Mineralocorticoid Receptor Haplotypes on Social Development During Adolescence and Young Adulthood

Endedijk

Nelemans

Schür

et al. 2019

J Youth Adolescence

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The development of social behavior could be affected by stressful parenting. The mineralocorticoid receptor, one of the two main receptors for the stress hormone cortisol, plays a vital role in adequate responses to stress. Therefore, the effects of stressful parenting on social development (i.e., empathic concern, perspective taking and prosocial behavior) may be moderated by functional genetic variation in mineralocorticoid receptor haplotypes (a combination of alleles). A group of 343 adolescents (44.3% females) was followed from the age of 13 until 24 years. Growth curve analyses showed lower levels of prosocial behaviors and a slower increase in empathic concern and perspective taking in adolescents who reported more stressful parenting. In contrast, relatively higher levels of prosocial behavior, empathic concern and perspective taking were present in combination with stress resilient mineralocorticoid receptor haplotypes. Despite sex differences in social development with earlier social development for girls, no consistent sex differences were found with regard to mineralocorticoid receptor haplotypes. The current study showed that genetic variation in mineralocorticoid receptor impacts the social development during adolescence and young adulthood.

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The Effect of Mineralocorticoid and Glucocorticoid Receptor Antagonism on Autobiographical Memory Recall and Amygdala Response to Implicit Emotional Stimuli

Cited by 13 publications

References 53 publications

Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

The Neurobiology of Reduced Autobiographical Memory Specificity

The Role of Stressful Parenting and Mineralocorticoid Receptor Haplotypes on Social Development During Adolescence and Young Adulthood

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