The effect of minocycline on beta-amyloid-induced memory and learning deficit in male rats: A behavioral, biochemical, and histological study

Mahmoudian, Zahra Gholami; Komaki‬, Alireza; Rashidi, Iraj; Amiri, Iraj Sadegh; Ghanbari, Ali

doi:10.1016/j.jchemneu.2022.102158

Cited by 5 publications

(4 citation statements)

References 52 publications

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“…The production of phosphorylated tau protein drives in ammatory pathways, resulting in a vicious cycle. formation stimulates in ammatory cascades creating a vicious circle [7,10,14,15]. These ndings are consistent with our ndings, which revealed that a single intraperitoneal dose of LPS (5 mg/kg) induced neuroin ammation in the hippocampus.…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, previous studies found that minocycline decreased NF-kB in a rat model of spinal cord injury (SCI)induced neuropathic pain [24] and TLR-4 and COX-2 in the spinal cord of LPS rats, which protect against LPS -induced pain allodynia and hyperalgesia [16,25]. Minocycline also inhibited the development of amyloid and tau proteins in rats [10]. Importantly, the underlying molecular mechanism of action, dosedependent and preventive-therapeutic effects of minocycline in the hippocampus of LPS rats have not yet been fully explored.…”

Section: Discussionmentioning

confidence: 99%

“…It is a semi-synthetic second-generation tetracycline antibiotic (7-dimethylamino-6-dimethyl-6-deoxy-tetracycline) with a small molecular size (495 KDa) and good solubility that may pass the blood-brain barrier (BBB) into the cerebrospinal uid. In several neuroin ammatory diseases, it has anti-amyloid, antioxidant, antiin ammatory and anti-apoptotic properties [10]. In our previous studies, we found that minocycline prevents oxidative stress [11] and improves learning and memory impairment by inhibiting microglia and astrocytes activation in the hippocampus of LPS rats [12].…”

Section: Introductionmentioning

confidence: 99%

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Minocycline mitigates tau pathology via modulating the TLR-4/NF-кβ signalling pathway in the hippocampus of Alzheimer disease’s rat model

Qaid

Abdullah

Zakaria

et al. 2023

Preprint

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Introduction: The neuroinflammatory response was seen to impact the formation of phosphorylated tau protein in Alzheimer’s disease (AD). This study aims to investigate the molecular mechanism of minocycline in reducing phosphorylated tau protein formation in the hippocampus of lipopolysaccharide (LPS)-induced rats. Methods Fifty adult male Sprague Dawley (SD) rats were randomly allocated to 1 of 5 groups: control, LPS (5 mg/kg), LPS + minocycline (25 mg/kg), LPS + minocycline (50 mg/kg) and LPS + memantine (10 mg/kg). Minocycline and memantine were administered intraperitoneally (i.p) for two weeks, and LPS was injected i.p. once on day 5. ELISA was used to determine the level of phosphorylated tau protein in SD rats' hippocampal tissue. The density and expression of Toll-like receptor-4 (TLR-4), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кβ), tumour necrosis factor-alpha (TNF-α), and cyclooxygenase (COX)-2 were determined using Western blot and immunohistochemistry. Results Minocycline, like memantine, prevented LPS-induced increase in phosphorylated tau protein level via reduced density and expression of TLR-4, NF-кβ, TNF-α and COX-2 proteins in rat hippocampal tissue. Interestingly, higher doses were shown to be more neuroprotective than lower doses. Conclusion This study suggests that minocycline suppresses the neuroinflammation signalling pathway and decreased phosphorylated tau protein formation induced by LPS in a dose-dependent manner. Minocycline has been recommended can be used as a preventative and therapeutic drug for neuroinflammatory diseases such as AD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Minocycline mitigates tau pathology via modulating the TLR-4/NF-кβ signalling pathway in the hippocampus of Alzheimer disease’s rat model

Qaid

Abdullah

Zakaria

et al. 2023

Preprint

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“…An elevated plus maze test was used to measure anxiety levels (Gholami Mahmoudian et al, 2023). The maze consisted of two open arms without walls (50 × 10 × 0.5 cm), two enclosed arms with walls (50 × 10 × 40 cm), and a central area (10 × 10 cm) elevated at 50 cm height.…”

Section: Elevated Plus Maze (Epm)mentioning

confidence: 99%

Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats

Wang,

et al. 2024

Front. Mol. Neurosci.

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Prolonged or repeated exposure to stress elevates the risk of various psychological diseases, many of which are characterized by central nervous system dysfunction. Recent studies have demonstrated that circular RNAs (circRNAs) are highly abundant in the mammalian brain. Although their precise expression and function remain unknown, they have been hypothesized to regulate transcriptional and post-transcriptional gene expression. In this investigation, we comprehensively analyzed whether restraint stress for 2 days altered the circRNA expression profile in the amygdala of male rats. The impact of restraint stress on behavior was evaluated using an elevated plus maze and open field test. Serum corticosterone levels were measured using an enzyme-linked immunosorbent assay. A total of 10,670 circRNAs were identified using RNA sequencing. Ten circRNAs were validated by reverse transcription and quantitative polymerase chain reaction analysis. Gene ontology and Kyoto encyclopedia of genes and genomes pathway analyzes supported the notion that genes associated with differentially expressed circRNAs are primarily implicated in neuronal activity and neurotransmitter transport. Moreover, the three differentially expressed circRNAs showed high specificity in the amygdala. Overall, these findings indicate that differentially expressed circRNAs are highly enriched in the amygdala and offer a potential direction for further research on restraint stress.

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Minocycline as a prospective therapeutic agent for cancer and non-cancer diseases: a scoping review

Rezaei,

Moqadami,

Khalaj-Kondori

2023

Naunyn-Schmiedeberg's Arch Pharmacol

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The effect of minocycline on beta-amyloid-induced memory and learning deficit in male rats: A behavioral, biochemical, and histological study

Cited by 5 publications

References 52 publications

Minocycline mitigates tau pathology via modulating the TLR-4/NF-кβ signalling pathway in the hippocampus of Alzheimer disease’s rat model

Minocycline mitigates tau pathology via modulating the TLR-4/NF-кβ signalling pathway in the hippocampus of Alzheimer disease’s rat model

Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats

Minocycline as a prospective therapeutic agent for cancer and non-cancer diseases: a scoping review

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