The effect of moderate hemodilution with Fluosol-DA or normal saline on acetaminophen disposition in the rat

White

1990

Antipyrine disposition has been determined in the rat following administration of Fluosol-DA by an intravenous infusion without blood removal or a haemodilution procedure, and compared with data from sham haemodiluted rats (blood removed and returned) and control rats which only received antipyrine. Antipyrine total body and renal clearance and the formation clearance of two of its metabolites were affected differently at 48 h by the pretreatments. The haemodilution procedure enhanced, the sham haemodilution reduced, and the intravenous infusion had no effect on the phenobarbitone inducible cytochrome P450 isoenzyme activity.

Section: Discussionmentioning

confidence: 99%

Influence of the method of Fluosol-DA administration on antipyrine metabolism in the rat

White

1990

“…It has been established that Fluosol-DA (Fluosol) and specifically the PFCs in the emulsion induce the phenobarbitone-inducible microsomal cytochrome P450 isoenzymes both in concentration and activity (Armstrong & Lowe 1989;Mishin et a1 1989;Shrewsbury & White 1990a). Fluosol haemodilution decreased the nonmicrosomal sulphation of paracetamol at 48 h in rats (Shrewsbury & White 1990b).…”

mentioning

confidence: 88%

The Effect of Moderate Haemodilution with Fluosol-DA or Hespan on the Nonmicrosomal Acetylation of Sulphadimidine in the Rat

Hong

White

et al. 1992

The effects of Fluosol-DA (Fluosol) and Hespan haemodilution on the nonmicrosomal acetylation of sulphadimidine were studied in male rats. Fluosol increased the acetylsulphadimidine percent excreted in urine, the metabolic formation rate constant (kf), and the formation clearance (CLF) for 72 h after haemodilution without any significant changes in the sulphadimidine apparent volume of distribution (Vd) or total body clearance (CL). Hespan haemodilution increased the acetylsulphadimidine percent excreted in urine only at 48 h while significantly decreasing the sulphadimidine clearance, urinary excretion rate constant (ku), and renal clearance (CLR) for 72 h. The enhanced N-acetyltransferase activity after Fluosol haemodilution may have therapeutic consequences for concomitantly given drugs metabolized by this enzyme.

Plasma volumes, blood volumes, and plasma protein concentrations after moderate haemodilution with Fluosol-DA or normal saline in the rat

1991

Plasma volumes, blood volumes, and plasma total protein, albumin, and bilirubin concentrations have been determined in rats for 72 h following 20 or 40 mL kg-1 haemodilution with Fluosol-DA or 0.9% NaCl. Haemodilution with 20 mL kg-1 of either haemodiluent had no influence on the measured values. Plasma and blood volumes did not change after Fluosol-DA haemodilution at 40 mL kg-1, but albumin and bilirubin concentrations were decreased for 72 h. Only bilirubin concentrations were decreased for 72 h following haemodilution with 40 mL kg-1 of 0.9% NaCl. It was concluded that changes in a drug's plasma protein binding, and not the plasma or blood volume, are responsible for the reported alterations in a drug's apparent volume of distribution after haemodilution.