The Effect of Modified Sini Decoction on Survival Rates of Patients with Hepatitis B Virus Related Acute-on-Chronic Liver Failure

Abstract

Aim of the Study.To verify the effect of modified sini decoction on patients with hepatitis B virus related acute-on-chronic liver failure.Materials and Methods.A retrospective cohort study was conducted. Patients who had been treated with modified sini decoction and standard comprehensive internal medicine were assigned to an observation group, and patients who had been treated with standard comprehensive internal medicine were selected as a control group. The total bilirubin (TBIL), albumin (ALB), alanine aminotransferase (ALT), prothrombin activity (PTA), CTP, and MELD scores were analyzed at weeks 4, 8, and 12 after treatment, respectively. Meanwhile, the 12-week survival rate was analyzed.Results.The levels of TBIL and ALT were remarkably decreased, while the levels of ALB and PTA were remarkably increased in both groups at weeks 4, 8, and 12 after treatment, respectively, but the effects in the observation group were greater (P < 0.05). The CTP and MELD scores at 8-week and 12-week were lower in the observation group than in the control group (P < 0.05). At 12 weeks, the mean survival times of the observation group and the control group were 66.7 and 45.5 d, respectively. Significant improvement of 12-week survival rate [39/62 (62.9%) versus 18/50 (36.0%), P = 0.001] was observed in the observation group after treatment.Conclusions.Modified sini decoction could protect the liver function and improve the survival rates of patients with hepatitis B virus related acute-on-chronic liver failure.

Adipose-derived mesenchymal stem cells attenuate acute lung injury and improve the gut microbiota in septic rats

“…Millions of years of coevolution have shaped the symbiotic relationship between humans and microorganisms, in which the gut bacteria play a crucial role in the metabolism of human nutrients, while the human gut provides a nutrient rich environment for the bacteria. Therefore, an imbalance in the gut microecology leads to the occurrence or aggravation of disease [32][33][34][35][36][37]. Dysfunction of the intestinal epithelium, dysfunction of the immune system, and translocation of enteropathogenic bacteria are considered to be the key factors leading to infectious complications and multiple organ dysfunction syndromes.…”

Study on the mechanism of quercetin in Sini Decoction Plus Ginseng Soup to inhibit liver cancer and HBV virus replication through CDK1

“…Our previous studies found that the potential therapeutic effect of SNRS on ALF might be through promoting the expression of PPARα and increasing the level of ATP in liver tissue, inhibiting the necrosis of liver cells, reducing liver cell damage, and improving liver function (He et al, 2022). Our previous studies also found that modified sini decoction could protect the liver function and improve the survival rates of patients with hepatitis B virus related acute-on-chronic liver failure (Luo et al, 2019). Moreover, a study have shown that sini decoction inhibits tumor progression and enhances anti-tumor immune response in mouse colon cancer model (Chen et al, 2023).…”

“…Sini Decoction Plus Ginseng Soup (SNRS) was first described in “Treatise on Febrile Diseases” written by Zhong‐jing Zhang, which consists of four herbs: Zhi Gan Cao (licorice), Gan Jiang (dried ginger), Fu Zi (aconite lateral root) and Ren Shen (ginseng). Some previous studies have found that sini decoction can treat a variety of liver diseases and cancer (Chen et al., 2023; He et al., 2022; Luo et al., 2019). Our previous studies demonstrated that SNRS inhibited hepatocyte necrosis, reduced hepatocyte damage, and improved liver function in mice with acute liver failure (He et al., 2022).…”

Adipose-Derived Mesenchymal Stem Cells Attenuate Acute Lung Injury Through Regulation of the Gut Microbiota in Septic Rats

“…Millions of years of coevolution have shaped the symbiotic relationship between humans and microorganisms, in which the gut bacteria play a crucial role in the metabolism of human nutrients, while the human gut provides a nutrient rich environment for the bacteria. Therefore, an imbalance in the gut microecology leads to the occurrence or aggravation of disease [24][25][26][27][28][29] . Dysfunction of the intestinal epithelium, dysfunction of the immune system, and translocation of enteropathogenic bacteria are considered to be the key factors leading to infectious complications and multiple organ dysfunction syndromes.…”