The effect of monocular occlusion on hippocampal c-Fos expression in domestic chicks (Gallus gallus)

Morandi-Raikova, Anastasia; Mayer, Uwe

doi:10.1038/s41598-020-64224-9

Cited by 24 publications

(21 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, until recently, only few studies investigated the presence of similar effects at the neurobiological level (e.g., Johnston et al 1995). In our recent works, we started to tackle this issue reporting cases of neurobiological lateralisation in various brain areas of dark-incubated chicks (e.g., Mayer et al 2017;Lorenzi et al 2019;Morandi-Raikova and Mayer 2020;Morandi-Raikova et al 2021; see also Mayer et al 2016;Lorenzi et al 2017;Golüke et al 2019;Corrales Parada et al 2021 for similar trends). Intriguingly, in our latest work (Morandi-Raikova et al 2021), we described a case anatomical lateralisation in the entopallium of dark-incubated chicks.…”

Section: Discussionmentioning

confidence: 99%

Light-incubation effects on lateralisation of single unit responses in the visual Wulst of domestic chicks

et al. 2021

Self Cite

View full text Add to dashboard Cite

Since the ground-breaking discovery that in-egg light exposure triggers the emergence of visual lateralisation, domestic chicks became a crucial model for research on the interaction of environmental and genetic influences for brain development. In domestic chick embryos, light exposure induces neuroanatomical asymmetries in the strength of visual projections from the thalamus to the visual Wulst. Consequently, the right visual Wulst receives more bilateral information from the two eyes than the left one. How this impacts visual Wulst’s physiology is still unknown. This paper investigates the visual response properties of neurons in the left and right Wulst of dark- and light-incubated chicks, studying the effect of light incubation on bilaterally responsive cells that integrate information from both eyes. We recorded from a large number of visually responsive units, providing the first direct evidence of lateralisation in the neural response properties of units of the visual Wulst. While we confirm that some forms of lateralisation are induced by embryonic light exposure, we found also many cases of light-independent asymmetries. Moreover, we found a strong effect of in-egg light exposure on the general development of the functional properties of units in the two hemispheres. This indicates that the effect of embryonic stimulation goes beyond its contribution to the emergence of some forms of lateralisation, with influences on the maturation of visual units in both hemispheres.

show abstract

Section: Discussionmentioning

confidence: 99%

Light-incubation effects on lateralisation of single unit responses in the visual Wulst of domestic chicks

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…In terms of TnA expression, high expression levels of 5-HTR2C have been observed in the rodent medial amygdala, which is considered to be the counterpart of the avian TnA 51 , 52 , suggesting the conserved roles of 5-HTR2C in the mammalian medial amygdala and avian TnA. For example, exposure to novel objects or novel environments is associated with the activation of TnA in avian species 53 , 54 . Avian species exhibit a reluctance to approach novel objects or novel environments (neophobia).…”

Section: Discussionmentioning

confidence: 99%

The dorsal arcopallium of chicks displays the expression of orthologs of mammalian fear related serotonin receptor subfamily genes

Fujita

Aoki

Mori

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Fear is an adaptive emotion that elicits defensive behavioural responses against aversive threats in animals. In mammals, serotonin receptors (5-HTRs) have been shown to modulate fear-related neural circuits in the basolateral amygdala complex (BLA). To understand the phylogenetic continuity of the neural basis for fear, it is important to identify the neural circuit that processes fear in other animals. In birds, fear-related behaviours were suggested to be processed in the arcopallium/amygdala complex and modulated by the serotonin (5-HT) system. However, details about the distribution of 5-HTRs in the avian brain are very sparsely reported, and the 5-HTR that is potentially involved in fear-related behaviour has not been elucidated. In this study, we showed that orthologs of mammalian 5-HTR genes that are expressed in the BLA, namely 5-HTR1A, 5-HTR1B, 5-HTR2A, 5-HTR2C, 5-HTR3A, and 5-HTR4, are expressed in a part of the chick arcopallium/amygdala complex called the dorsal arcopallium. This suggests that serotonergic regulation in the dorsal arcopallium may play an important role in regulating fear-related behaviour in birds. Our findings can be used as a basis for comparing the processing of fear and its serotonergic modulation in the mammalian amygdala complex and avian arcopallium/amygdala complex.

show abstract

“…The copyright holder for this preprint this version posted February 25, 2022. ; https://doi.org/10.1101/2022.02.24.481770 doi: bioRxiv preprint involved in filial imprinting (Horn, 2004) and was not responsive to novel environments in our previous studies (Mayer et al, 2018;Morandi-Raikova and Mayer, 2020;).…”

Section: Introductionmentioning

confidence: 70%

Active exploration of a novel environment drives the activation of the hippocampus-amygdala complex of domestic chicks

Morandi-Raikova

Mayer

2022

Preprint

Self Cite

View full text Add to dashboard Cite

In birds, like in mammals, the hippocampus critically mediates spatial navigation through the formation of a spatial map. This study investigates the impact of active exploration of a novel environment on the hippocampus of young domestic chicks, during formation of a new spatial map. Chicks that were free to actively explore the novel environment exhibited a significantly higher neural activation (measured by c-Fos expression), compared to those that passively observed the novel environment from a restricted area. The difference was limited to the anterior and the dorsolateral parts of the intermediate hippocampus. Furthermore, the nucleus taeniae of the amygdala showed a higher c-Fos expression in the active exploration group than the passive observation group. In both brain regions, brain activation correlated with the number of locations that chicks visited during the test. This suggest that the increase of c-Fos expression in the hippocampus is related to increased firing rates of spatially coding neurons. Furthermore, our study indicates a functional linkage of the hippocampus and nucleus taeniae of the amygdala in processing spatial information. Overall, with the present study, we confirm that, in birds like in mammals, exploration of novel environments activates hippocampus, which is likely related to the formation of new spatial representations.

show abstract

The effect of monocular occlusion on hippocampal c-Fos expression in domestic chicks (Gallus gallus)

Cited by 24 publications

References 127 publications

Light-incubation effects on lateralisation of single unit responses in the visual Wulst of domestic chicks

Light-incubation effects on lateralisation of single unit responses in the visual Wulst of domestic chicks

The dorsal arcopallium of chicks displays the expression of orthologs of mammalian fear related serotonin receptor subfamily genes

Active exploration of a novel environment drives the activation of the hippocampus-amygdala complex of domestic chicks

Contact Info

Product

Resources

About