The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)

Waer, Hanaa F.; Edress, Saleh

doi:10.21608/ejhm.2006.17916

Cited by 13 publications

(10 citation statements)

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“…3,4 The production of ROS increased lipid peroxidation, disrupting the intracellular antioxidant/FR balance. 13 In the present experiment, we found that MSG causes adverse effect on the liver and heart by (i) altering serum lipid profile, (ii) increasing level of hepato-cardiac marker enzyme and pro-inflammatory cytokines, and (iii) causing oxidative stress via disturbing the redox status to reduce cellular viability and tissue damage in dose-dependent manner. Moreover, the injurious impact of MSG was higher in 600 mg/kg body weight dose as compared to the rest of the groups.…”

Section: Discussionsupporting

confidence: 49%

“…Furthermore, MSG has been directly associated with oxidative stress. 3,4,13 MSG causes oxidative stress in this study by lowering SOD, CAT, and glutathione levels while increasing TBARS and NO levels in hepatic and cardiac tissue. All of these events have resulted in enhanced hepatic and cardiac damage, as seen by the other two elevated cardiac marker enzymes 17 LDH and CK-MB.…”

Section: Discussionmentioning

confidence: 52%

“…3,4 The production of ROS increased lipid peroxidation, disrupting the intracellular antioxidant/FR balance. 13…”

Section: Discussionmentioning

confidence: 99%

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Monosodium glutamate causes hepato-cardiac derangement in male rats

2021

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People in the fast-food era rely on pre-packaged foods and engage in limited physical activity, which leads to a shift in eating patterns. Monosodium glutamate (MSG), a dietary ingredient used in this sort of cuisine, has been found to be hazardous to both experimental animals and humans. The objective of this study was to explore at the unnecessary changes caused by consuming MSG in secret and exceeding the recommended dosage. Hence, we decided to evaluate the impact of MSG by using three different doses (200, 400, and 600 mg/kg body weight orally) for 28 days in rats. We uncovered that all three MSG dosages result in a rise in body weight, dyslipidemia, inflammatory response, and hepato-cardiac marker enzymes, all of which imply hepatic and cardiac toxicity. Furthermore, changes in redox status suggest oxidative stress, which was higher in all three MSG dosages although not as much as in the MSG-600 group when compared to control. Such effects eventually manifested themselves in tissue architecture of the liver and heart, resulting in severe hepato-cardiac derangement, but the degree of tissue damage was greater in the MSG-600 group. As a result, it is possible that MSG has a negative influence on the liver and heart. However, the MSG-600 group showed a substantial effect, indicating that MSG should not be used in food preparation. Therefore, the findings of the study may aid in the formulation of health-care strategies and serve as a warning to the general public regarding the use of MSG in daily diet.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 52%

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Monosodium glutamate causes hepato-cardiac derangement in male rats

2021

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“…Free glutamic acid is combined with sodium, and it is a neurotransmitter that caused nerves to die. MSG acted as excitotoxin (17). brain regions, such as the cerebral cortex, cerebellum, and hippocampus (18).…”

Section: Mosaad and Sabrymentioning

confidence: 99%

Toxicity of monosodium glutamate intake on different tissues induced oxidative stress: A Review

Al-Otaibi

Mansour

Elabd

et al. 2022

Journal of Medical and Life Science

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Monosodium glutamate (MSG) is one of the commonest food additives in the developed world and it is commonly used as a flavor enhancer. MSG can be found in various concentrations in numerous food products. It is the salt of glutamic acid, one of the naturally occurring amino acids. Aim of work: the present review was prepared to illustrate the effects of Monosodium Glutamate on different vital tissues like pulmonary tissues, brain, liver, kidney, testes, and others. Monosodium glutamate treatment showed numerous pathological changes in different vital tissues like the lung, including highly congested blood vessels, granuloma, ruptured bronchial walls, narrowed alveolar sacs, fibrosis, and increased collagen fibers which might induce oxidative stress Also, Monosodium glutamate treated rats showed decreased DNA content and increased protein content, increased amyloid-β protein content and increased PAS +ve materials in different tissues. Conclusion: the present study concluded that monosodium glutamate consumption led to numerous dystrophic changes in different tissues which might induce oxidative stress Therefore, MSG is considered a toxic agent due to increased production of ROS, so that, the ingestion of this substance by humans should be reviewed and great attention must be directed towards this substance to avoid its highly desirable uses.

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“…Monosodium Glutamate can enhance the taste of food but some results of MSG study showed that even though MSG is safe for consumption, it also can cause toxicity against certain organs function as it affects the appetite and promote weight loss [4], affect the activities of the motion [3], can damage the arcuate nucleus in the hypothalamus [5], MSG can also cause uterine fibroids in animals, and decreased quantity of animal infant [6]. Organ damage caused by MSG may also occur due to the oxidative stress and apoptosis as well as hypoxia [7],…”

Section: Introductionmentioning

confidence: 99%

The Effect of Monosodium Glutamate Administration on Estradiol Levels on Pregnant Wistar Rats

Ariendha¹,

Apriyanti²,

Almasi‐Hashiani³

et al. 2021

Advances in Health Sciences Research

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The purpose of this study was to see the influence of the MSG administratsion to the estrogens levels, progesterone levels, and the quantity of infant on pregnant Wistar rats. The design of this study was experimental research with post test only control group design on 24 samples pregnant albino Wistar rats. The sample was divided into four groups, one control group and three treatment group. The control group was not given the MSG while the treatment group 1, 2 and 3 were given MSG with a dose of 43.2 mg, 86.4 mg, and 172.8 mg for 16 days pregnancy. The levels of estradiol rats were measured using Enzyme Linked Immunosorbent Assay (ELISA) in the Biomedicine Laboratsory Medical Faculty of Andalas University. Data analysis was conducted by using the Kruskal Wallis Test to know the levels of estradiol and then continued with Mann Whitney Test. The results of this study were the MSG have an effect on estradiol levels (p-value < 0.05). In conclusion, the median estradiol levels were higher in the treatment group compared to the control group.

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The Effect of Monosodium Glutamate (MSG) On Rat Liver And The Ameliorating Effect Of “Guanidino Ethane Sulfonic acid (GES)” (Histological, Histochemical and Electron Microscopy Studies)

Cited by 13 publications

References 0 publications

Monosodium glutamate causes hepato-cardiac derangement in male rats

Monosodium glutamate causes hepato-cardiac derangement in male rats

Toxicity of monosodium glutamate intake on different tissues induced oxidative stress: A Review

The Effect of Monosodium Glutamate Administration on Estradiol Levels on Pregnant Wistar Rats

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