The effect of montelukast on early‐life wheezing: A randomized, double‐blinded placebo‐controlled study

Keskin, Özlem; Yılmaz, Ebru; Motzkus, Christine; Saçkesen, Cansın; Lilly, Craig M.; Kalaycı, Ömer

doi:10.1111/pai.12822

Cited by 10 publications

(9 citation statements)

References 31 publications

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“…The use of montelukast was the most significant protective factor for hospitalization due to wheezing. Some studies in preschool wheezers have shown that montelukast was effective for reducing caregiver-observed wheezing, the need for salbutamol and acute exacerbations that required oral corticosteroids or hospitalization ( 33 , 34 ). However, a recent meta-analysis did not demonstrate benefit of montelukast in preschoolers with recurrent wheezing, but it raised the need of studies that evaluate a montelukast responder phenotype ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Associated With Health Care Utilization in Preschool Recurrent Wheezers in a Tropical Environment

Muñoz¹,

Guevara²,

Escamilla³

et al. 2021

Front. Allergy

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Introduction: The severity of wheezing episodes is related with the need for health services, but the factors associated with health care utilization in preschool recurrent wheezers in underdeveloped regions are unclear.Objective: To evaluate the factors associated with health care utilization in preschool recurrent wheezers in Cartagena, Colombia.Methods: One hundred twenty-seven recurrent wheezers (age 2–6 years old) who were admitted to the emergency room (ER) due to wheezing in a Pediatric reference hospital in Cartagena were included. Children were evaluated by means of questionnaires and classified according to the number of ER visits, need for hospitalization and history of intensive care unit (ICU) admission due to wheezing within the last year. Total serum IgE and specific IgE to house dust mite allergens (HDM) were measured by ImmunoCAP® and allergen sensitization was evaluated by skin prick tests (SPT).Results: The maternal report of nocturnal cough without fever in their children increased the risk to have ≥5 ER visits in the last year due to wheezing. The use of montelukast was negatively associated with hospitalization, while a history of pneumonia and lack of tap water, increased the risk of hospitalization due to wheezing. A history of bronchiolitis, family history of asthma, cohabiting with two or more siblings, passive exposure to smoke and lack of sewage facilities increased the risk of ICU admission due to wheezing. The presence of atopy evaluated by SPT reactivity, total IgE levels or specific IgE to HDM were not associated with health care utilization. We also found that seroprevalence of positive IgE (≥0.35 kU/L) was 27% to B. tropicalis and 20.3% to D. pteronyssinus but the prevalence of positive IgE sensitization to these allergens was below 2% and 8% when evaluated by SPT, respectively.Conclusions: Poverty indicators are associated with ICU admission in a group of preschool recurrent wheezers and should be considered as aggravating factors for wheezing. These factors must be systematically assessed in the medical approach in underdeveloped regions in the tropics. Nocturnal cough without fever is a symptom associated with frequent ER visits while atopy was not associated with health care utilization in preschool recurrent wheezers.

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Section: Discussionmentioning

confidence: 99%

Risk Factors Associated With Health Care Utilization in Preschool Recurrent Wheezers in a Tropical Environment

Muñoz¹,

Guevara²,

Escamilla³

et al. 2021

Front. Allergy

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“…Another interesting finding from our review is the shift to study specific subgroups in childhood asthma, including preschool wheezing (32, 33), children with asthma and EIB symptoms (19, 24, 25, 35), mild vs. severe asthma (12–14, 16), controlled vs. uncontrolled asthma (16, 21, 37), and asthma exacerbations (29–31, 36). Most studies focused on the diagnostic potential to differentiate between two well-defined groups at a certain time-point (cross-sectional study design).…”

Section: Discussionmentioning

confidence: 99%

“…By means of the search strategy, we identified 10 longitudinal studies of which two were randomized double-blind placebo controlled trials. Keskin et al studied the effect of montelukast on preschool wheezing, and measured eicosanoids in EBC at first visit (32). Unfortunately, EBC was not collected after start of the trial in order to evaluate the effect of intervention on EBC markers.…”

Section: Findings From Longitudinal Studiesmentioning

confidence: 99%

Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective

2019

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Exhaled breath condensate (EBC) was introduced more than two decades ago as a novel, non-invasive tool to assess airway inflammation. This review summarizes the latest literature on the various markers in EBC to predict asthma in children. Despite many recommendations and two comprehensive Task Force reports, there is still large heterogeneity in published data. The biggest issue remains a lack of standardization regarding EBC collection, preservation, processing, and analysis. As a result, published studies show mixed or conflicting results, questioning the reproducibility of findings. A joint, multicenter research study is urgently needed to address the necessary methodological standardization.

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“…Montelukast is a cysteinyl‐leukotriene‐1 receptor antagonist and has been recently studied as a drug candidate for reducing the number of wheezing episodes in children 3‐36 months of age . The randomized, double‐blinded, placebo‐controlled study suggested that treatment with montelukast had beneficial effects only during the first 7 days of treatment compared to placebo and may be used to replace salbutamol during that time period.…”

Section: Asthma Treatmentmentioning

confidence: 99%

Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. EAACI's major goals include supporting the promotion of health, in which the prevention of allergy and asthma plays a critical role, and disseminating the knowledge of allergic disease to all stakeholders. In 2018, the remarkable progress in the identification of basic mechanisms of allergic and respiratory diseases as well as the translation of these findings into clinical practice were observed. Last year's highlights include publication of EAACI guidelines for allergen immunotherapy, many EAACI Position Papers covering important aspects for the specialty, better understanding of molecular and cellular mechanisms, identification of biomarkers for disease prediction and progress monitoring, novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, introduction of new drugs to the clinics, recently completed phase three clinical studies, and publication of a large number of allergen immunotherapy studies and meta‐analyses.

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The effect of montelukast on early‐life wheezing: A randomized, double‐blinded placebo‐controlled study

Abstract: Background: Cysteinyl-leukotrienes are increased in the airways of infants with virus-

Cited by 10 publications

References 31 publications

Risk Factors Associated With Health Care Utilization in Preschool Recurrent Wheezers in a Tropical Environment

Risk Factors Associated With Health Care Utilization in Preschool Recurrent Wheezers in a Tropical Environment

Exhaled Breath Condensate in Childhood Asthma: A Review and Current Perspective

Highlights and recent developments in airway diseases in EAACI journals (2018)

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