Animals being maintained on an inadequate diet demonstrate more efficient maze performance than do the control animals (Anderson & Smith, 1926;Griffiths & Senter, 1954). When B-complex vitamins, thiamine, or ribotlavin are withheld during the nursing period only, and the animals tested after weaning on an adequate diet, there is a significant diminution in maze performance (Maurer: 1935a(Maurer: , 1935b. A positive correlation between thiamine concentration in the diet of very young rats and subsequent learning ability has been clearly established by O'Neill (1949). Curiously, Vitamin A, protein, phosphorus, or iron deficiencies during this period result in no observable learning deficit (Bernhardl: 1936a(Bernhardl: , 1936b(Bernhardl: , 1936c. That vitamin levels of the fetus may affect postnatal learning ability and intelligence has been suggested by the works of Whitlcy, O 'Dell, and Hogan (1951) and Harrell, Woodyard, and Gates (1956).The work reported herein is unique in that for the first time, to the author's knowledge, a vitamin and mineral deficiency has been restricted to a specific interval in the prenatal period and the intelligence of the offspring tested after a normal weaning period.
METHOD SubjectsThe iVs were white rats of the Charles River Laboratories strain. The females were virgins weighing between 200 and 250 gm.