The effect of moxidectin 0,1% vs ivermectin 0,08% on milk production in sheep naturally infected by gastrointestinal nematodes

Abstract

BackgroundGastrointestinal nematode (GIN) infection is one of the main constraints to sheep production both in temperate and tropical countries. Economic losses caused by GIN are related to decreased production, treatment costs and even animal death. The present paper was aimed at assessing the anthelmintic efficacy (based on faecal egg count reduction) of moxidectin and ivermectin both admistered per os at dose rate of 0.2 mg/Kg body weight and the benefit of anthelmintic treatments on milk production in a commercial dairy sheep farms in central Italy whose animals were naturally infected by GIN.ResultsThe treatment with moxidectin was highly effective (> 98%) from day 7 until day 75, and effective (90-98%) until day 105. The treatment with ivermectin was highly effective (> 98%) from day 7 until day 14, effective (90-98%) at day 28 and moderately effective (80-89%) on day 45. The milk productions in the treated groups were significantly higher than those of the control group.ConclusionIn conclusion, the results of the present study demonstrated that moxidectin and ivermectin adminstered per os according to the manufacturer's instructions were both effective and safe anthelmintics in sheep. The total milk production was higher in the treated groups than the control group. Overall, animals treated with moxidectin had a milk production 40.8% higher than control group; whereas animals treated with ivermectin had a milk production 32.2% higher than control group.

The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT‐TCF pathway responses in human cancer

“…In support of this, WNT-TCF response blocking activity is detected at up to tenfold lower concentrations than those reported for chloride ion deregulation (this work; Drinyaev et al, 2004). The finding that Moxidectin is more potent than Ivermectin in controlling intestinal nematodes (Fatima et al, 2007;Cringoli et al, 2009) but similarly or less active on human cancer cells (this work), further supports different modes of action of macrocyclic lactones on cancer cells vs. parasites. The specificity and selectivity of Ivermectin and Selamectin we describe are also inconsistent with ubiquitous effects of these macrocyclic lactones through alterations of anion-selective Cys-loop channels (Hibbs & Gouaux, 2011;Lynagh & Lynch, 2012) or Farnesyl X receptors (Jin et al, 2013).…”

Interactions between parasitic infections and reproductive efficiency in sheep

“…Anthelmintic treatment has also been found to increase milk production (Rinaldi et al, 2007). More specifically, Fthenakis et al (2005) and Cringoli et al (2009) have reported that administration of an anthelmintic with a long persistent activity at the final stage of pregnancy, resulted in a significant (up to 40%) increase in total milk production throughout the subsequent lactation period. Finally, Fthenakis et al (2000) have identified a lower milk production in ewes with sarcoptic mange: up to 18% compared to healthy animals.…”

Efficacy of a moxidectin/triclabendazole oral formulation against mixed infections of Fasciola hepatica and gastrointestinal nematodes in sheep

“…Most of the available anthelminthics for controlling GIN in sheep fall into three main families: benzimidazoles, imidazothiazoles, and macrocyclic lactones. Moxidectin, a macrocyclic lactone, at a dosage of 0.2 mg/kg bodyweight, has been shown to be effective against pulmonary infections and GIN in sheep (Dorchies et al, 1996;Cringoli et al, 2009). Moxidectin has a longer persistence in sheep and maintains higher milk production than ivermectin (Cringoli et al, 2009).…”

“…Moxidectin, a macrocyclic lactone, at a dosage of 0.2 mg/kg bodyweight, has been shown to be effective against pulmonary infections and GIN in sheep (Dorchies et al, 1996;Cringoli et al, 2009). Moxidectin has a longer persistence in sheep and maintains higher milk production than ivermectin (Cringoli et al, 2009). The most widely used drug to combat Fasciola hepatica in sheep is a benzimidazole derivative, triclabendazole (TCBZ), due to its high efficacy against adult and immature flukes (Boray et al, 1983;Fairweather, 2005).…”