The effect of mucin-containing artificial saliva on severe xerostomia

Sgravenmade, Ej; Roukema, P.A.; Panders, Ak

doi:10.1016/s0300-9785(74)80009-8

Cited by 55 publications

(18 citation statements)

References 10 publications

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“…24 Five classes of salivary substitutes are available commercially: aqueous ion solutions, aqueous ion and carboxymethylcellulose preparations, mucin containing solutions, glycoprotein-containing agents and enzyme containing gel. 24 The main problems associated with artificial salivas are the short duration of action [25][26][27][28] and in some cases objectionable taste. 28 The use of pilocarpine to treat radiation induced xerostomia is not a new concept.…”

Section: S C I E N T I F I C a R T I C L Ementioning

confidence: 99%

“…24 The main problems associated with artificial salivas are the short duration of action [25][26][27][28] and in some cases objectionable taste. 28 The use of pilocarpine to treat radiation induced xerostomia is not a new concept. It has been shown 20 that use of 5mg tablets, three times a day for three months was effective in increasing salivary flow and providing symptomatic improvement.…”

Section: S C I E N T I F I C a R T I C L Ementioning

confidence: 99%

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An Investigation into the Use of Pilocarpine as a Sialagogue in Patients With Radiation Induced Xerostomia

Frydrych

Davies

Slack‐Smith

et al. 2002

Australian Dental Journal

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Background: Radiation therapy to the head and neck region can be an effective form of treatment for malignancies. Unfortunately damage to salivary glands may occur. Treatment of resultant dry mouth is at present very poor. The purpose of this pilot study was to investigate whether pilocarpine dissolved in artificial saliva and administered in a mouth spray would be effective in relieving such symptoms. Methods: Twenty-three patients with radiation induced hyposalivation were recruited for this randomized, double-blind investigation. Subjects were randomly allocated to placebo or control medicaments used for eight weeks. All subjects were evaluated for the severity of their xerostomia associated symptoms prior to administration of the spray and again eight weeks later. Results: The questionnaire and the visual analogue scale did not reveal any improvements in the dry mouth symptoms between cases and controls. Sideeffects were reported among cases, mostly mild and tolerable. All patients taking pilocarpine (with base salivary flow rates > 0ml/min) demonstrated improvement in stimulated and unstimulated salivary flow rates. Candida counts decreased among the cases and controls although decrease among the cases was much greater. Conclusions:The results obtained indicate that provided residual functioning salivary tissue exists, pilocarpine used as formulated is effective and warrants further investigation.

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Section: S C I E N T I F I C a R T I C L Ementioning

confidence: 99%

Section: S C I E N T I F I C a R T I C L Ementioning

confidence: 99%

An Investigation into the Use of Pilocarpine as a Sialagogue in Patients With Radiation Induced Xerostomia

Frydrych

Davies

Slack‐Smith

et al. 2002

Australian Dental Journal

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“…This indi cates that mucins have a greater ability to complex calcium ions than CMC. The af finity of mucins for calcium (and/or phos phates) is relatively high, probably be cause of the presence of sialic acid ['s-Gravenmade et al, 1974['s-Gravenmade et al, , 1981. A fur ther increase in the mucin concentration (solution V) resulted in a lower level of re hardening.…”

Section: Discussionmentioning

confidence: 99%

“…The most important ones are the sensation of a dry mouth, difficulties in oral func tioning (mastication, swallowing, and speech), nocturnal oral discomfort, and a burning sensation of the oral mucosa and tongue [Bertram, 1967;Mason and Chis holm, 1975). Synthetic salivas containing carboxymethylcellulose (CMC) or mucin and salts in equivalent concentrations as in mixed human saliva, and sweetened with sorbitol or xylitol, have been used in the management of the dry mouth syn drome [Matzker and Schreiber, 1972;' s-Gravenmade et al, 1974;Shannon et al, 1977]. These substitutes have been shown to reduce the patients' complaints of xer ostomia [Klestovet al, 1981;Vissink et al, 1983].…”

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confidence: 99%

Rehardening Properties of Mucin- or CMC-Containing Saliva Substitutes on Softened Human Enamel

et al. 1985

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The rehardening of artificially softened human enamel by nine different saliva substitutes and four control solutions in vitro has been investigated by microhardness measurements. The saliva substitutes were all based on the same formula, containing mucins or carboxymethylcellulose (CMC) as the main macromolecules, and phosphate, calcium and fluoride as the main electrolytes, and sorbitol or xylitol. All the saliva substitutes had a rehardening potential. The largest reduction of the rehardening potential was observed after addition of high concentrations of CMC or mucins and the addition of sorbitol. The best rehardening properties were observed for low viscous mucin- or CMC-containing saliva substitutes with xylitol.

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“…In addition to moistening the mucosa, aiding the digestive process, providing ions for remineralization, and chemically buffering the oral cavity, saliva provides lubrication of oral tissues I- [1][2][3][4][5][6][7][8][9][10][11][12]. The lubricating capacity of saliva has intuitively been correlated with the viscosity of the secretion by previous investigators [7,[12][13][14][15]. These lubricating properties are provided mainly by high molecular weight O-and N-linked glycoproteins that order water molecules and increase the viscosity of saliva beyond that of water [2, 5, 8-11, 15, 16].…”

Section: Introductionmentioning

confidence: 99%

Rheology of stimulated whole saliva in a typical pre-orthodontic sample population

Kusy

Schäfer

1995

J Mater Sci: Mater Med

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The dynamic viscosity (t~) of stimulated whole saliVa in a typical pre-orthodontic sample population was characterized as a function of temperature (T). Samples were collected from 30 adolescents or young adults, after screening for factors that are known to have an effect on salivary viscosity. Using a cone and plate viscometer, 1.5 ml of stimulated whole saliva was evaluated at a constant shear rate of 450s -1 from T=20°C to T= 40°C. Data from the I~-T plots showed a negative dependence of the form, p = a-bT, over a range of I~ from 1.08 to 2.45 centipoise (cps) at 34 °C. Most of the samples fell into a narrow envelope, where the mean I~ of the saliva samples ranged from 2.42+0.61 cps at 20°C to 1.57_+0.32 cps at 37°C. With regard to sample stability, viscosity-time plots indicated that a small but predictable decrease in t~ occurred during the 3 h period. The i~-Tplots generated from fresh and frozen saliva samples demonstrated an appreciable change in p as a result of refrigeration. With regard to sample reproducibility, viscometric data obtained from a typical pre-orthodontic patient over a 1-week period fluctuated within a fairly broad envelope of values.

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The effect of mucin-containing artificial saliva on severe xerostomia

Cited by 55 publications

References 10 publications

An Investigation into the Use of Pilocarpine as a Sialagogue in Patients With Radiation Induced Xerostomia

An Investigation into the Use of Pilocarpine as a Sialagogue in Patients With Radiation Induced Xerostomia

Rehardening Properties of Mucin- or CMC-Containing Saliva Substitutes on Softened Human Enamel

Rheology of stimulated whole saliva in a typical pre-orthodontic sample population

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