The effect of mucosal dryness on the electrogustometric threshold

Lee, Ji-Young; Kim, Ji Rak; Byun, Jin‐Seok; Choi, Jae‐Kap; Jung, Jae‐Kwang

doi:10.1016/j.physbeh.2022.113826

Cited by 1 publication

(2 citation statements)

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“…However, the ability to taste these chemicals has been reported to be a heritable trait 7,43 . Although EGM has been thought to be an objective measurement tool in GD, the result of EGM is dependent on various other factors, such as mucosal dryness and the condition of the electrode, and the usefulness of EGM is not conclusive 44,45 . Therefore, we suggest that chemical gustatory function tests, including subjective questionnaires, are recommended to truly evaluate the presence of GD.…”

Section: Discussionmentioning

confidence: 97%

“…7,43 Although EGM has been thought to be an objective measurement tool in GD, the result of EGM is dependent on various other factors, such as mucosal dryness and the condition of the electrode, and the usefulness of EGM is not conclusive. 44,45 Therefore, we suggest that chemical gustatory function tests, including subjective questionnaires, are recommended to truly evaluate the presence of GD. Furthermore, since lifestyle factors, such as consumption of a Western-style diet, can result in variations in chemosensory abilities, 46 culture-specific gustatory function tests with corresponding normal ranges should be established and implemented for the proper diagnosis of GD in PD.…”

Section: Discussionmentioning

confidence: 99%

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Gustatory dysfunction is related to Parkinson's disease: A systematic review and meta‐analysis

Kwak

Kim

Min

2023

Int Forum Allergy Rhinol

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BackgroundOlfactory dysfunction has been reported to be involved in Parkinson's disease (PD) pathogenesis. However, gustatory dysfunction in PD has not been evaluated as in‐depth as olfactory dysfunction. We reviewed the previously published studies regarding gustatory function in PD patients and suggested the possibility that gustatory dysfunction may also be associated with PD.MethodsMEDLINE, Cochrane Library, Embase, and PubMed databases were searched for studies evaluating gustatory function in PD patients. We used the standardized mean difference and a 95% confidence interval (CI) as the effect analysis index regarding the taste strip test. The relative risk and 95% CI were used as the effect analysis index for the questionnaires and propylthiouracil (PTU)/phenylthiocarbamide (PTC) perception test. Statistical heterogeneity was assessed using forest plots, Cochran's Q, and the I2 statistic; heterogeneity was considered high when I2 was over 75%. Publication bias was assessed by funnel plots and the Egger bias test.ResultsWe identified 19 articles that reported the results of gustatory function tests in PD patients and healthy controls. Most of these studies used various gustatory tests, including taste strips, questionnaires, taste solutions, PTU/PTC perception tests, and electrogustometry, and reported significantly lower gustatory function in PD patients than in the controls. However, several articles reported contradictory results.ConclusionsBased on these studies, gustatory dysfunction is closely related to PD. However, the number of studies and enrolled subjects was small, and a unified gustatory function test was lacking. Therefore, further studies with larger populations and normalized gustatory function tests are needed.

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Section: Discussionmentioning

confidence: 97%