The Effect of Multidisciplinary Team Discussion Intervention on the Prognosis of Advanced Colorectal Cancer

Zhang, Huaqi; Yu, Ji-Shang; Wei, Zhewei; Wu, Wenhui; Zhang, Changhua

doi:10.7150/jca.56171

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…In the MDTC group, the treatment time, cancer recurrence/metastasis rate, and risk of death were lower. Thus, they approved that this type of intervention speeds up the treatment process and reduces the risk of death for patients with advanced colorectal cancer [20]. These results were consistent with the outcomes of the current study.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of endometrial cancer based on a multidisciplinary team in Sulaimaniyah, Iraq

Hussein,

Fattah

2023

JZS

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Background: Using a multidisciplinary team is a natural progression in cancer care, reflecting the gains achieved by many professions and disciplines and the use of various therapeutic modalities and patient support. Objectives: To investigate the prevalence of endometrial cancer, related risk factors, management, and follow-up before and after multidisciplinary team care (MDTC). Methods: This cross-sectional observational study was conducted on 186 patients with endometrial cancer confirmed by endometrial biopsy cytology (endometrioid/non-endometrioid type). Patient data on clinical, surgical, pathological, and adjuvant therapies were collected, including age, body mass index (BMI), surgical procedure, nodal staging, and final pathological analysis. Assessment of risk factors and clinical follow-up was done by the MDTC method. Results: The patient’s age at menstruation was >12 years in 151 (83.9%) patients and <12 years in 29 (16.1%) patients. No significant difference was observed between the two groups in examining cancer and evaluating risk factors. However, the evaluations in the MTC group were associated with minor changes in order to improve and manage risk factors. Conclusions: The MDTC can be effective in the overall management of endometrial cancer.

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Section: Discussionsupporting

confidence: 90%

Evaluation of endometrial cancer based on a multidisciplinary team in Sulaimaniyah, Iraq

Hussein,

Fattah

2023

JZS

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“…Glyceropholipid is a major component of cell membrane, which is involved in signal transduction between cells . Glyceropholipid can bind to antigen-presenting molecules and affect the function of the immune system . According to the blood biochemical indices of male rats, no changes were observed in the immune-related cells and chemicals, such as white blood cells.…”

Section: Discussionmentioning

confidence: 99%

Chronic Toxicity of Genetically Modified Maize with Cry1Ab-ma Gene and Its Effect on Serum Metabolites in Rats

Wang¹,

Hu²,

Lu³

et al. 2023

J. Agric. Food Chem.

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Genetic engineering has inserted the crystallin (Cry) gene of Bacillus thuringiensis into the genes of maize to cultivate a variety of transgenic insect-resistant maizes. At present, genetically modified maize with Cry1Ab-ma gene (maize CM8101) was in the stage of safety verification. In this study, a 1-year chronic toxicity test was carried out to evaluate the safety of maize CM8101. Wistar rats were selected for the experiment. Rats were randomly divided into three groups and fed the corresponding diets: genetically modified maize group (CM8101 group), parental maize group (Zheng58 group), and AIN group. Rat serum and urine were collected at the third, sixth, and twelfth months of the experiment, and viscera were collected at the end of the experiment for detection. Metabolomics was used to analyze the metabolites in the serum of rats at the 12th month. While the CM8101 group rats' diets were supplemented with 60% maize CM8101, no obvious poisoning symptoms were found in rats, and no poisoning death occurred. There were no negative effects on body weight, food intake, blood and urine indices, or organ histopathological examination results. Furthermore, metabolomics results revealed that, when compared to group differences, the gender of rats had a more obvious effect on metabolites. The CM8101 group primarily changed linoleic acid metabolism in female rats, while glyceropholipid metabolism was altered in male rats. In rats, consumption of maize CM8101 did not result in significant metabolic dysfunction.

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“…Obvious achievements have also been made in advanced esophageal cancer, advanced gastric cancer, and advanced colorectal cancer using MDT discussion intervention [ 29 , 30 , 31 ]. The results of the above studies further validate our conclusions and show that MDT discussion intervention can also be effectively applied to improve outcomes in other complex advanced tumor cases.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, as far as we are aware, the present cohort study is the first to explore the role of an MDT in the management of the diagnosis and treatment of advanced GIST. Multidisciplinary discussions about the impact of interventions on the efficiency of the treatment process are a major concern for many physicians, who are concerned that multiple MDT discussions might delay treatment for patients [ 30 ]. However, the results of the paper illustrate that MDT discussion intervention is an effective measure to improve outcomes, including PS and the survival of patients with advanced GISTs.…”

Section: Discussionmentioning

confidence: 99%

Improving Outcomes in the Advanced Gastrointestinal Stromal Tumors: The Role of the Multidisciplinary Team Discussion Intervention

Ran

Zhou

et al. 2023

JPM

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Objectives: There is disagreement over the prognostic value of multidisciplinary team (MDT) discussion for advanced gastrointestinal stromal tumors (GISTs). This study examined how an MDT affected patients with advanced GISTs in terms of their overall survival (OS) and whether it may enhance their performance status (PS). Methods: A retrospective data analysis was conducted on patients with advanced GISTs between 2000 and 2022. Depending on whether they had received the MDT discussion intervention, the patients were split into two groups. The OS between the two groups was compared using the Kaplan–Meier method. A multivariate Cox regression analysis was used to analyze the prognostic variables for advanced GIST. Fisher’s test was used to investigate the relationship between an MDT and PS. Results: There were 122 patients with an MDT and 117 patients without an MDT in this study. In comparison to the non-MDT group, the MDT group showed a higher survival rate (5-year OS, 42.62% vs. 28.21%, p < 0.05). MDT was an independent prognostic factor for OS in univariate and multivariate Cox regression analyses (p < 0.05). Fisher’s test revealed that there were variations in PS between the two groups (p < 0.05). Conclusions: The effectiveness of an MDT in the treatment of advanced GIST was examined for the first time in this study. MDT discussion intervention is an effective measure for improving the outcomes of patients with advanced GISTs.

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The Effect of Multidisciplinary Team Discussion Intervention on the Prognosis of Advanced Colorectal Cancer

Cited by 9 publications

References 21 publications

Evaluation of endometrial cancer based on a multidisciplinary team in Sulaimaniyah, Iraq

Evaluation of endometrial cancer based on a multidisciplinary team in Sulaimaniyah, Iraq

Chronic Toxicity of Genetically Modified Maize with Cry1Ab-ma Gene and Its Effect on Serum Metabolites in Rats

Improving Outcomes in the Advanced Gastrointestinal Stromal Tumors: The Role of the Multidisciplinary Team Discussion Intervention

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