Nurses as part of the hospital organization, of course, are required to be able to provide effective and efficient services. But in reality, the services received by patients are not in line with expectations, this can be due to a lack of supervision and the presence of conflicts between nurses. This study aims to analyse the effect of supervision on the performance of nurses with work conflicts as moderators at Royal Prima Marelan Hospital. Explanatory descriptive quantitative research method, conducted at Royal Prima Marelan Hospital in July 2022. For the population of 151 people, a sampling technique using Slovin with a confidence level of 95%, obtained 139 samples. Data analysis used multiple linear regression, and T-test and Test F. Research results of supervisory variables and conflict variables had a calculation of 4,522 and 3,870 with a table t value of 1.977 then the calculated>table value at α= 5% (4.522 and 3.870>1.977), with a significant value of 0.002 smaller than 0.05 (0.000<0.05) so that the H0 research results were rejected and H1 was accepted. The value of the coefficient of determination (Adjusted R Square) is 0.430. Supervision variables (X1) and Work Conflict variables (X2 partially affect nurse performance (Y) at Royal Prima Marelan Hospital. The value of the coefficient of determination is 43%, while the remaining 57% is a variation of other variables that were not studied in this study, such as motivation, incentives, and so on.