The Effect of Mushroom Beta‐Glucans from Solid Culture of Ganoderma lucidum on Inhibition of the Primary Tumor Metastasis

Abstract

This study evaluates the effect of mushroom beta-glucans (MBGS) derived from solid culture of Ganoderma lucidum on tumor inhibition by examining size of the primary tumor and rate of metastasis in Lewis lung carcinoma (LLC) bearing mice (C57BL/6), given oral administration of MBGS with radiation therapy. A previous result showed that MBGS enhances NK cell-mediated cytotoxicity in mice without LLC bearing in advance. Furthermore, applications of MBGS in conjunction with radiation therapy were effective in controlling tumor growth, and rate of metastasis, life threatening, and can potentially serve as a protective factor for wounds and hair loss that resulted from the overgrowth of primary tumor in LLC bearing mice.

Ganoderma lucidum: A Review with Special Emphasis on the Treatment of Various Cancer

“…When MBGS is administered in conjugation with radiation therapy it serves as a protective factor for the hair loss and wounds due to the overgrowth of primary tumor in LLC bearing mice. It is also effective in controlling tumor growth and rate of metastasis [41].…”

Beta-(1,3/1,6)-D-glucan Helps to Decrease Opportunistic Infections in Crohn's Disease Patients Treated with Biological Therapy

“…A previous results showed that beta-glucans enhanced NK cell-mediated cytotoxicity in mice without lung carcinoma bearing in advance. Furthermore, applications of beta-glucans in conjuction with radiation therapy were effective in controlling tumor growth, and rate of metastasis, life threatening and can potentially serve as protective factor for wounds and hair loss that resulted from overgrowth of primary tumor in Lewis lung carcinoma bearing mice [5].…”

Hepatorenal Syndrome Associated with the use of Reishi Fungus

“…Ganoderma lucidum, also known as lingzhi, mannentake, immortality mushroom, and red reishi mushroom, is the oldest known mushroom species used in Chinese and Japanese medicine, i.e. for more than 2000 years (1). It is believed that herbal drugs produced from this mushroom can cure diseases such as cardiovascular diseases, diabetes, renal failure, and cancers (1).…”

“…for more than 2000 years (1). It is believed that herbal drugs produced from this mushroom can cure diseases such as cardiovascular diseases, diabetes, renal failure, and cancers (1). In our presentation, we aim to discuss a case with acute hepatorenal failure associated with the use of reishi mushroom.…”