The Effect of Mycoplasma on the Karyology of Normal Cells

Paton, Gillian R.; Jacobs, Jonathan P.; Perkins, F. T.

doi:10.1111/j.1749-6632.1967.tb27707.x

Cited by 14 publications

(2 citation statements)

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“…Several investigators have demonstrated that mycoplasmas induce chromosomal aberrations in cultured cells (10,50,130,131,185,186). Most commonly, the aberrations consist .of achromatic gaps and chromatid breaks, but translocations, dicentrics, pulverization, and other gross abnormalities have been observed ( Fig.…”

Section: Karyologic Changes In Mycoplas-ma-infected Tissue Culture Cellsmentioning

confidence: 99%

Mycoplasmas and cell cultures.

Stanbridge¹

1971

Bacteriological Reviews

118

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Such terms are now in disfavor and the correct generic name, Mycoplasma, should be used. Recently the mycoplasmas have been classified into two separate families, the sterol-requiring Mycoplasmataceae and the sterol-nonrequiring Acholeplasmataceae (44). To the present time, over 30 named species of mycoplasmas have been included within the two families. In addition there are several unidentifiable isolates (L. Hayflick, personal communication). The above classification refers to classic (large-colony) mycoplasmas. It does not include T-strain mycoplasmas (so called, because they form tiny colonies approximately one-fourth the size of classic mycoplasma colonies) on agar. T-strain mycoplasmas were first isolated by Shepard from human urino-genital tracts (170). They have now been isolated from various animals. The T-strain group, as a whole, is unclassified at the present time. A unique requirement for urea (171), in addition to sterol requirement, for growth of these mycoplasmas has prompted the suggestion that they should be included as a separate genus in the order Mycoplasmatales (156a). MORPHOLOGY OF MYCOPLASMAS The mycoplasma organism is distinctive for its small size of 130 to 300 nm and for the lack of a cell wall, the limiting boundary being a plasma 206

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Section: Karyologic Changes In Mycoplas-ma-infected Tissue Culture Cellsmentioning

confidence: 99%

Mycoplasmas and cell cultures.

Stanbridge¹

1971

Bacteriological Reviews

118

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“…New and persistent chromosome varieties were found; these were telocentric, metacentric, and subtelocentric types. Paton, Jacobs, and Perkins (1967) studying chromosomes in WI 38 cells, reported that three human mycoplasma species caused changes which included chromatid breaks, structural abnormalities, and increased polyploidy. M. pharyngis (orale 1), M. fermentans, and M. hominis were studied.…”

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confidence: 99%