The Effect of N-Acetylcysteine and Ascorbic Acid-2-Phosphate Supplementation on Mesenchymal Stem Cell Function in B6.C-Lep<sup>ob</sup>/J Type 2 Diabetic Mice

Maartens, Michelle; Kruger, Maria Jacoba; Vyver, Marí van de

doi:10.1089/scd.2021.0139

Cited by 3 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gaining a point for demonstrating it targets several hallmarks of aging, NAC has been shown to decrease oxidative stress (only studied in conjunction with glycine), improve population doubling time of mesenchymal stem cells (only studied in conjunction with ascorbic acid), decrease the expression of senescence-associated genes, decrease mitochondrial dysfunction, and restore nutrient sensing. [73][74][75]…”

Section: Original Drugsmentioning

confidence: 99%

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

Leone,

Barzilai

2024

MRAJ

View full text Add to dashboard Cite

The biological mechanisms of aging drive the development of chronic diseases such as cardiovascular disease, diabetes, dementia, and cancer that dominate our current medical system. Geroscience-guided approaches seek to mitigate these pathological consequences of aging by targeting the fundamental hallmarks of aging. Using modalities that modulate these aging mechanisms to reinforce longevity we can prevent the onset of these diseases as well as target many of them at once. In this way, geroscience-guided approaches hope to extend both lifespan and healthspan in the near future. This article builds upon a previous paper which proposed a standardized process for evaluating FDA-approved medications for their geroscience potential and prioritized them to reflect preclinical and clinical evidence. In this article, we provide an update of the previous list of candidate gerotherapeutics to reflect the new and rapidly evolving evidence. We include the geroscience-guided evidence for three new FDA-approved drugs which did not have strong arguments for inclusion before: bisphosphonates, GLP-1 receptor agonists, beta blockers. This updated prioritization should help guide the efforts and financial investments for translating geroscience and allow immediate progress involving such candidate gerotherapeutics, especially the top 4 drugs: SGLT2 inhibitors, metformin, bisphosphonates, and GLP-1 receptor agonists. Since all of these drugs have been approved for safety and used extensively, repurposing them as gerotherapeutics should be considered in older adults.

show abstract

Section: Original Drugsmentioning

confidence: 99%

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

Leone,

Barzilai

2024

MRAJ

View full text Add to dashboard Cite

show abstract

Counteracting diabetes-induced adipose tissue derived-stromal cell senescence

Govender,

Kruger,

van de Vyver

2024

Biochimie

View full text Add to dashboard Cite

Role of oxidative stress in impaired type II diabetic bone repair: scope for antioxidant therapy intervention?

Li,

Alenazi,

Dally

et al. 2024

Front. Dent. Med

View full text Add to dashboard Cite

Impaired bone healing is a significant complication observed in individuals with type 2 diabetes mellitus (T2DM), leading to prolonged recovery, increased risk of complications, impaired quality of life, and increased risk of patient morbidity. Oxidative stress, resulting from an imbalance between the generation of reactive oxygen species (ROS) and cellular/tissue antioxidant defence mechanisms, has been identified as a critical contributor to the pathogenesis of impaired bone healing in T2DM. Antioxidants have shown promise in mitigating oxidative stress and promoting bone repair, particularly non-enzymic antioxidant entities. This comprehensive narrative review aims to explore the underlying mechanisms and intricate relationship between oxidative stress, impaired bone healing and T2DM, with a specific focus on the current preclinical and clinical evidence advocating the potential of antioxidant therapeutic interventions in improving bone healing outcomes in individuals with T2DM. From the ever-emerging evidence available, it is apparent that exogenously supplemented antioxidants, especially non-enzymic antioxidants, can ameliorate the detrimental effects of oxidative stress, inflammation, and impaired cellular function on bone healing processes during uncontrolled hyperglycaemia; and therefore, hold considerable promise as novel efficacious therapeutic entities. However, despite such conclusions, several important gaps in our knowledge remain to be addressed, including studies involving more sophisticated enzymic antioxidant-based delivery systems, further mechanistic studies into how these antioxidants exert their desirable reparative effects; and more extensive clinical trial studies into the optimisation of antioxidant therapy dosing, frequency, duration and their subsequent biodistribution and bioavailability. By enhancing our understanding of such crucial issues, we can fully exploit the oxidative stress-neutralising properties of these antioxidants to develop effective antioxidant interventions to mitigate impaired bone healing and reduce the associated complications in such T2DM patient populations.

show abstract

The Effect of N-Acetylcysteine and Ascorbic Acid-2-Phosphate Supplementation on Mesenchymal Stem Cell Function in B6.C-Lep^ob/J Type 2 Diabetic Mice

Cited by 3 publications

References 39 publications

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

Counteracting diabetes-induced adipose tissue derived-stromal cell senescence

Role of oxidative stress in impaired type II diabetic bone repair: scope for antioxidant therapy intervention?

Contact Info

Product

Resources

About

The Effect of N-Acetylcysteine and Ascorbic Acid-2-Phosphate Supplementation on Mesenchymal Stem Cell Function in B6.C-Lepob/J Type 2 Diabetic Mice

Cited by 3 publications

References 39 publications

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

Counteracting diabetes-induced adipose tissue derived-stromal cell senescence

Role of oxidative stress in impaired type II diabetic bone repair: scope for antioxidant therapy intervention?

Contact Info

Product

Resources

About

The Effect of N-Acetylcysteine and Ascorbic Acid-2-Phosphate Supplementation on Mesenchymal Stem Cell Function in B6.C-Lep^ob/J Type 2 Diabetic Mice