The Effect of Naproxen on Acute Mountain Sickness and Vascular Responses to Hypoxia

Rt, Meehan; Cymerman, Allen; Rock, Peter; Cs, Fulco; Hoffman, Joseph C.; Abernathy, Charles O.; Needleman, Samuel W.; Jt, Maher

doi:10.1097/00000441-198607000-00003

Cited by 19 publications

(8 citation statements)

References 21 publications

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“…It was concluded that vasodilating prostaglandins did not have a major role in the genesis of hypoxia-induced retinal vasodilatation in AMS [104]. The exact role of cytokines and prostaglandins in high-altitude sickness needs to be further investigated.…”

Section: Uvea and Immunologymentioning

confidence: 96%

Ophthalmological Effects of High Altitude

Karaküçük

Mirza²

2000

Ophthalmic Res

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High altitude has various effects on human beings. Altitude-related illnesses are a frequent cause of morbidity and occasional mortality in travelers to high altitudes throughout the world. The mountaineers all around the world are familiar with this condition, which is called acute mountain sickness (AMS). The primary altitude illnesses are AMS, high-altitude pulmonary edema and high-altitude cerebral edema. Altitude has potential undesired ophthalmological effects. The pathogenesis of these syndromes remains unclear despite considerable research in this field. Most of these problems are primarily preventable with an adequate level of information before and during travel. Further studies are needed to reveal the exact relationship between high altitude and ophthalmological findings. In this article, ophthalmological effects of high altitude, likely to be encountered by mountaineers as well as other enthusiasts of high altitude sports are reviewed. Emphasis on aviation and aerospace medicine is briefly given under related subtitles.

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Section: Uvea and Immunologymentioning

confidence: 96%

Ophthalmological Effects of High Altitude

Karaküçük

Mirza²

2000

Ophthalmic Res

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“…129,192 -194 Tyrosine improved symptoms, moods, and various performances in volunteers who showed average or greater than average adverse effects during an environmental challenge in which they had been treated with a placebo. 129,192,193 The drugs furosemide, 150 phenytoin, 195,196 and naproxen, 197 are ineffective or possibly harmful. Sleep preparations, alcohol, and sedatives should be avoided.…”

Section: Medical Strategiesmentioning

confidence: 99%

Cognitive performance, mood, and neurological status at high terrestrial elevation

Banderet¹,

Shukitt-Hale²

2002

PsycEXTRA Dataset

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. ABSTRACT (Maximum 200 words)Cognitive and psychomotor performance and mood states, including many critical behavioral functions such as sleep, memory, ■ reasoning, and vigilance, are significantly impaired by ascent to HTE higher than 3,000 m. Impairments in behavior caused by HTE can degrade military operations because the judgment and rate and accuracy of performance of military personnel can be affected. Such adverse effects have distinct and measurable time courses; onset of some effects is immediate (cognitive performance), whereas the onset of others is delayed (symptoms of AMS or adverse moods). The behavioral consequences of HTE are primarily dependent on the level of altitude, the duration of exposure the rate of ascent, an individual's state of physiological acclimation or acclimatization, characteristics of the task performed, and characteristics of the individual such as hypoxic sensitivity. Military history documents that the adverse effects induced by HTE need to be considered when military operations at altitude are planned and undertaken. Current research indicates that some performance decrements induced by ascent to extremely high mountains (e.g., Mount Everest, 8,848 m) may persist for a year or longer after return to lower elevations. Psychological, operational, and medical strategies have been employed to minimize these adverse effects. Psychological strategies often involve training and familiarization with the adverse effects that will be experienced at high altitude. Operational strategies include staging at intermediate altitudes, acclimatizing, and using supplemental oxygen from tanks of oxygen generators. Medical strategies often involve the use of medications to improve functioning at altitude and techniques to avoid complications. In most situations, multiple strategies are employed. The strategies now available and new developments to come will ensure that high-altitude military operations in the future will be less affected by adverse changes in cognitive and psychomotor performance and mood.14. SUBJECT TERMS high altitude, hypoxia, cognitive performance, moods, symptoms, time course of altitude effects, behavior NUMBER OF PAGES 3516. PRICE CODE

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“…In agreement two randomized controlled trials suggested that aspirin is useful for preventing HAH [4, 12]. By contrast, naproxen [25] and carbasalate [26] did not prevent AMS compared with placebo. Unfortunately, both studies did not report the incidence of HAH.…”

Section: Discussionmentioning

confidence: 94%

Efficacy of ibuprofen on prevention of high altitude headache: A systematic review and meta-analysis

Xiong

Wang

et al. 2017

PLoS ONE

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ObjectiveIbuprofen is used to prevent high altitude headache (HAH) but its efficacy remains controversial. We conducted a systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) of ibuprofen for the prevention of HAH.MethodsStudies reporting efficacy of ibuprofen for prevention of HAH were identified by searching electronic databases (until December 2016). The primary outcome was the difference in incidence of HAH between ibuprofen and placebo groups. Risk ratios (RR) were aggregated using a Mantel-Haenszel random effect model. Heterogeneity of included trials was assessed using the I2 statistics.ResultsIn three randomized-controlled clinical trials involving 407 subjects, HAH occurred in 101 of 239 subjects (42%) who received ibuprofen and 96 of 168 (57%) who received placebo (RR = 0.79, 95% CI 0.66 to 0.96, Z = 2.43, P = 0.02, I2 = 0%). The absolute risk reduction (ARR) was 15%. Number needed to treat (NNT) to prevent HAH was 7. Similarly, The incidence of severe HAH was significant in the two groups (RR = 0.40, 95% CI 0.17 to 0.93, Z = 2.14, P = 0.03, I2 = 0%). Severe HAH occurred in 3% treated with ibuprofen and 10% with placebo. The ARR was 8%. NNT to prevent severe HAH was 13. Headache severity using a visual analogue scale was not different between ibuprofen and placebo. Similarly, the difference between the two groups in the change in SpO2 from baseline to altitude was not different. One included RCT reported one participant with black stools and three participants with stomach pain in the ibuprofen group, while seven participants reported stomach pain in the placebo group.ConclusionsBased on a limited number of studies ibuprofen seems efficacious for the prevention of HAH and may therefore represent an alternative for preventing HAH with acetazolamide or dexamethasone.

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The Effect of Naproxen on Acute Mountain Sickness and Vascular Responses to Hypoxia

Cited by 19 publications

References 21 publications

Ophthalmological Effects of High Altitude

Ophthalmological Effects of High Altitude

Cognitive performance, mood, and neurological status at high terrestrial elevation

Efficacy of ibuprofen on prevention of high altitude headache: A systematic review and meta-analysis

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