The effect of naproxen on the concentration of prostaglandins in human seminal fluid

Bendvold, E.; Gottlieb, Claes; Svanborg, K.; Bygdeman, M.; Eneroth, P.; Cai, Qi-Hang

doi:10.1016/s0015-0282(16)48623-1

Cited by 22 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, other NSAIDs such as flurbiprofen, acetylsalicylic acid, naproxen can decrease PG levels in human semen and increase fertility [68][69][70]83]. These findings can be partially explained by Isidori et al, that high baseline levels of PGs are harmful because they reduce testicular DNA synthesis and cause down regulation of the receptors for the same PGs.…”

Section: Discussionmentioning

confidence: 99%

“…The short treatment with naproxen did not have any impact on human fertility. The data suggest that the reduction of PGs is not secondary to the effect of naproxen on sperm characteristics [68]. However further studies need to be performed to assess the long-term effect of naproxen, or other NSAIDs on fertility and sperm characteristics (motility, morphology, density).…”

Section: Potential Effects Of Nsaids In Seminal Fluid Pgsmentioning

confidence: 94%

“…Bendvold et al showed that all PGs (PGE, PGF, 19-hydroxy-PGE, and 19-hydroxy-PGF,8α-19-hydroxy-PGF 2α , 8ß-19-hydroxy-PGF 1α ) were reduced in semen samples of six volunteers before, during and after treatment with naproxen 250 mg 3 times daily for 2 weeks [68]. Interestingly, the results showed that for maintaining normal sperm motility it is essential to have a balanced concentration ratio between 19-hydroxy-PGF and 19-hydroxy-PGE.…”

Section: Potential Effects Of Nsaids In Seminal Fluid Pgsmentioning

confidence: 99%

See 2 more Smart Citations

Arachidonic Acid Pathways and Male Fertility: A Systematic Review

Hoxha

Barbonetti

Zappacosta

2023

IJMS

View full text Add to dashboard Cite

Arachidonic acid (AA) is a polyunsaturated fatty acid that is involved in male fertility. Human seminal fluid contains different prostaglandins: PGE (PGE1 and PGE2), PGF2α, and their specific 19-hydroxy derivatives, 18,19-dehydro derivatives of PGE1 and PGE2. The objective of this study is to synthesize the available literature of in vivo animal studies and human clinical trials on the association between the AA pathway and male fertility. PGE is significantly decreased in the semen of infertile men, suggesting the potential for exploitation of PGE agonists to improve male fertility. Indeed, ibuprofen can affect male fertility by promoting alterations in sperm function and standard semen parameters. The results showed that targeting the AA pathways could be an attractive strategy for the treatment of male fertility.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Potential Effects Of Nsaids In Seminal Fluid Pgsmentioning

confidence: 94%

Section: Potential Effects Of Nsaids In Seminal Fluid Pgsmentioning

confidence: 99%

See 1 more Smart Citation

Arachidonic Acid Pathways and Male Fertility: A Systematic Review

Hoxha

Barbonetti

Zappacosta

2023

IJMS

View full text Add to dashboard Cite

show abstract

Indomethacin and Oxaprozin Lower Seminal Prostaglandin Levels But Do Not Influence Sperm Motion Characteristics and Serum Hormones of Young Healthy Men in a Placebo‐Controlled Double‐Blind Trial

Knuth

Kuhne

Crosby

et al. 1989

Journal of Andrology

View full text Add to dashboard Cite

To evaluate the influence of indomethacin and oxaprozin on reproductive function in healthy young men, 34 volunteers with normal semen parameters were recruited. In a randomized double-blind design, 12 men were treated with placebo, 12 received 600 mg/day of oxaprozin and 10 took indomethacin 25 mg t.i.d. This treatment phase lasted for 14 days after which a follow-up period extended for another 10 weeks. Sperm counts, percentage of motile and normally formed sperm cells, sperm velocity, linearity, lateral head displacement and beat frequency were evaluated by computerized image analysis once before treatment and at weekly intervals during the rest of the study. Prostaglandin levels in seminal plasma were significantly reduced after 2 weeks of treatment and remained suppressed for at least 2 additional weeks. In spite of this long lasting impairment of physiologic prostaglandin concentrations, no changes in any of the measured parameters were detectable when compared with the placebo group. Basal levels of testosterone, estradiol, LH, FSH, TSH and prolactin were unchanged. The response of hypophyseal hormones to a combined GnRH/TRH test before, during and after the treatment also was not affected. Overall, no negative influence of indomethacin or oxaprozin treatment on male reproductive function could be found in healthy volunteers. Since the active treatment phase was only 14 days, one can only speculate about long term effects of the tested drugs on reproductive parameters in men.

show abstract

Male fertility

Bygdeman¹

1986

Prostaglandins and Their Inhibitors in Clinical Obstetrics and Gynaecology

View full text Add to dashboard Cite

The effect of naproxen on the concentration of prostaglandins in human seminal fluid

Cited by 22 publications

References 8 publications

Arachidonic Acid Pathways and Male Fertility: A Systematic Review

Arachidonic Acid Pathways and Male Fertility: A Systematic Review

Indomethacin and Oxaprozin Lower Seminal Prostaglandin Levels But Do Not Influence Sperm Motion Characteristics and Serum Hormones of Young Healthy Men in a Placebo‐Controlled Double‐Blind Trial

Male fertility

Contact Info

Product

Resources

About