The Effect of Narrowband UV-B Treatment for Psoriasis on Vitamin D Status During Wintertime in Ireland

Abstract

To determine whether narrowband UV-B (NB-UV-B) may mediate its beneficial effect on psoriasis by increasingvitaminDlevels,andtoassesstheeffectofNB-UV-B on vitamin D status in patients with psoriasis in wintertime.

UVB and Vitamin D in Psoriasis

“…Psoriasis improved in all patients, with a reduction in the PASI score of about 75% on all regimens (59,73). Improvement in psoriasis correlated positively with the increase in 25(OH)D3 levels in one (58) (p=0.047; the group of patients treated with BUVB and NBUVB) but not in the other studies (57,61,62,73).…”

“…Improvement in psoriasis correlated positively with the increase in 25(OH)D3 levels in one (58) (p=0.047; the group of patients treated with BUVB and NBUVB) but not in the other studies (57,61,62,73). There was no correlation between change in serum 25(OH)D levels and change in PASI or change in DLQI in the study of psoriasis patients treated with NBUVB in Ireland (73). No relationship was found between levels of 25(OH)D and psoriasis but a negative correlation was found between the severity of psoriasis and the basal serum level of 1,25(OH)2D (80).…”

A Dermatologist's Perspective on Vitamin D

“…[1][2][3][4][5][6][7][8][9]51,65,66 It is well established that narrowband UV-B (311-313 nm) phototherapy results in increases in serum 25(OH)D levels. [72][73][74] Narrowband UV-B units are widely available in dermatology centers and offices and are also available as home units with a physician's prescription. [73][74][75] A study published in 2008 that evaluated more than 4600 patients who received narrowband UV-B phototherapy from 1985 to 2002 found no increase in skin cancer development.…”

“…This is the reason that we recommend referring these patients to our endocrinology colleagues for management with careful monitoring of serum 25(OH)D levels. 3,26,[72][73][74] The recent Endocrine Society Practice Guidelines on vitamin D recommended at least 6000 to 10,000 IU/d of vitamin D for patients with malabsorption disorders until a An explanation for this observation is that interferon-␥ levels are elevated in sarcoidosis; interferon-␥ is known to mediate an increase in the activity of 1-␣ hydroxylase, the enzyme responsible for the conversion of 25 76 …”

Narrowband Ultraviolet B Interferes with Gene Expression in the Peripheral Blood T Cells of Patients with Psoriasis

“…Some researchers believe that NB-UVB-radiated T cells can transfer immunosuppression, resulting in tumor induction [20]. Furthermore, NB-UVB treatment can affect vitamin D levels and protein kinase C delta-induced apoptosis [21], and evidence suggests that the therapeutic efficacy of NB-UVB for psoriatic lesions is accompanied by significantly increased serum vitamin D levels [22]. …”