The effect of natural antimicrobials against Campylobacter spp. and its similarities to Salmonella spp, Listeria spp., Escherichia coli, Vibrio spp., Clostridium spp. and Staphylococcus spp

Balta, Igori; Linton, Mark; Pinkerton, Laurette; Kelly, Carmel; Ştef, Lavinia; Peţ, Ioan; Ştef, D.; Criste, Adriana; Gundogdu, Ozan; Corcionivoschi, Nicolae

doi:10.1016/j.foodcont.2020.107745

Cited by 37 publications

(19 citation statements)

References 111 publications

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“…Recent developments in this area paved the way for new, more effective and environmentally friendly alternatives to tackle coccidial infections. These developments have placed host safety as the top priority, ensuring that few if any secondary effects are expressed as are often seen for antibiotics, anticoccidial or anti-parasitic drugs 9,10 .…”

mentioning

confidence: 99%

“…Phytobiotics and organic acids often inhibit pathogens, including parasites, and can modulate animal gastrointestinal tract health via multiple mechanisms 5,7,9,11 . Phytochemicals, such as saponins, exhibit a unique ability to adhere to the protozoan cholesterol cellular membrane of Eimeria spp., causing further lysis and cellular death 11,12 .…”

mentioning

confidence: 99%

“…Natural antimicrobial phytochemical blends enriched with organic acids are promising additions to pathogen control programmes because they can be easily integrated in animal feeds 9 . Commercial blends of organic acids such as Acidomix (Ammonium formate, formic acid, Ammonium Propionate), Activate (2-hydroxyl-4-calcium butyrate, fumaric acid, Benzoic acid) and Lacplus (lactic acid, citric acid, fumaric acid, phosphoric acid) reduced lesion scores, oocyst indices, increased body weight, and improved feed conversion ratio in E. tenella-infected chicks 1 .…”

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confidence: 99%

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The in vitro and in vivo anti-virulent effect of organic acid mixtures against Eimeria tenella and Eimeria bovis

Balta

Marcu

Linton

et al. 2021

Sci Rep

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Eimeria tenella and Eimeria bovis are complex parasites responsible for the condition of coccidiosis, that invade the animal gastrointestinal intestinal mucosa causing severe diarrhoea, loss of appetite or abortions, with devastating impacts on the farming industry. The negative impacts of these parasitic infections are enhanced by their role in promoting the colonisation of the gut by common foodborne pathogens. The aim of this study was to test the anti-Eimeria efficacy of maltodextrin, sodium chloride, citric acid, sodium citrate, silica, malic acid, citrus extract, and olive extract individually, in vitro and in combination, in vivo. Firstly, in vitro infection models demonstrated that antimicrobials reduced (p < 0.05), both singly and in combination (AG), the ability of E. tenella and E. bovis to infect MDBK and CLEC-213 epithelial cells, and the virulence reduction was similar to that of the anti-coccidial drug Robenidine. Secondly, using an in vivo broiler infection model, we demonstrated that AG reduced (p = 0.001) E. tenella levels in the caeca and excreted faeces, reduced inflammatory oxidative stress, improved the immune response through reduced ROS, increased Mn-SOD and SCFA levels. Levels of IgA and IgM were significantly increased in caecal tissues of broilers that received 0.5% AG and were associated with improved (p < 0.0001) tissue lesion scores. A prophylactic approach increased the anti-parasitic effect in vivo, and results indicated that administration from day 0, 5 and 10 post-hatch reduced tissue lesion scores (p < 0.0001) and parasite excretion levels (p = 0.002). Conclusively, our in vitro and in vivo results demonstrate that the natural antimicrobial mixture (AG) reduced parasitic infections through mechanisms that reduced pathogen virulence and attenuated host inflammatory events.

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confidence: 99%

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confidence: 99%

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confidence: 99%

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The in vitro and in vivo anti-virulent effect of organic acid mixtures against Eimeria tenella and Eimeria bovis

Balta

Marcu

Linton

et al. 2021

Sci Rep

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“…Biofilm-disrupting and antimicrobial properties of many naturally occurring compounds against pathogens have been previously explored [67][68][69]. Such compounds (Table 1) include different plant extracts and their components (e.g., containing polyphenols), essential oils (e.g., containing carvacrol) and marine inhabitants (algae extracts), and a number of these have been tested against campylobacters.…”

Section: Natural Antibiofilm Compoundsmentioning

confidence: 99%

“…Several studies found that reuterin and reuterin-related compounds exhibit antimicrobial and antibiofilm activities against wide range of Gram-positive and -negative bacteria including B. subtilis, Clostridium difficile, E. coli, Fusobacterium nucleatum, Listeria spp. and P. aeruginosa [67,89,[191][192][193][194]. Reuterin also suppressed the growth of Campylobacter strains with MIC range between 1.5 to 5.8 µM.…”

Section: Microorganism-derived Compoundsmentioning

confidence: 99%

Campylobacter Biofilms: Potential of Natural Compounds to Disrupt Campylobacter jejuni Transmission

Elgamoudi

Korolik

2021

IJMS

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Microbial biofilms occur naturally in many environmental niches and can be a significant reservoir of infectious microbes in zoonotically transmitted diseases such as that caused by Campylobacter jejuni, the leading cause of acute human bacterial gastroenteritis world-wide. The greatest challenge in reducing the disease caused by this organism is reducing transmission of C. jejuni to humans from poultry via the food chain. Biofilms enhance the stress tolerance and antimicrobial resistance of the microorganisms they harbor and are considered to play a crucial role for Campylobacter spp. survival and transmission to humans. Unconventional approaches to control biofilms and to improve the efficacy of currently used antibiotics are urgently needed. This review summarizes the use plant- and microorganism-derived antimicrobial and antibiofilm compounds such as essential oils, antimicrobial peptides (AMPs), polyphenolic extracts, algae extracts, probiotic-derived factors, d-amino acids (DAs) and glycolipid biosurfactants with potential to control biofilms formed by Campylobacter, and the suggested mechanisms of their action. Further investigation and use of such natural compounds could improve preventative and remedial strategies aimed to limit the transmission of campylobacters and other human pathogens via the food chain.

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Multifunctional skin dressings synthesized via one‐pot photopolymerization: Advancing wound healing and infection prevention strategies

Zambroni,

Martínez,

Cagnetta

et al. 2024

Polymers for Advanced Techs

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In the field of wound healing treatment, the development of new materials is essential to cover multiple functions, such as acceleration of the healing process, prevention of infection and response to stimuli, especially if they present lower costs or are easier to manufacture. These properties are of great importance to prompt skin cicatrization. In this work, new multifunctional skin dressings for wound healing and infection prevention are developed based on new hydrogel materials. The dressings are produced via a straightforward and environmentally friendly one‐pot photopolymerization manufacturing process utilizing vitamin B2 aqueous solutions as sensitizer, and energy‐efficient blue light sources. These dressings exhibit a high swelling capacity, pH and temperature responsiveness, biocompatibility, antimicrobial activity in the absence of conventional antibiotics, and are capable of promoting wound healing. The formulation is based on the combination of three monomers: 2‐((methacryloyloxy)ethyl)trimethylammonium chloride, methacrylic acid and N‐vinyl caprolactam. Collagen, hyaluronic acid, and essential oil of hop are added to enhance antimicrobial properties and stimulate regenerative cellular processes. In vivo experiments have demonstrated that pristine dressings are superior in promoting collagen and fibroblast regeneration and accelerating cicatrization as compared to dressings containing natural products. The dressing embedded with hop also displayed antimicrobial characteristics. The preparation and testing of these new efficient wound dressings are described. This study is distinctive in its integration of environmentally conscious manufacturing techniques with innovative material formulations, resulting in superior wound dressings that are both cost‐effective and highly functional. By achieving enhanced healing and infection prevention without the employment of conventional antibiotics, this work represents a substantial advancement in sustainable and effective wound care management.

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The effect of natural antimicrobials against Campylobacter spp. and its similarities to Salmonella spp, Listeria spp., Escherichia coli, Vibrio spp., Clostridium spp. and Staphylococcus spp

Cited by 37 publications

References 111 publications

The in vitro and in vivo anti-virulent effect of organic acid mixtures against Eimeria tenella and Eimeria bovis

The in vitro and in vivo anti-virulent effect of organic acid mixtures against Eimeria tenella and Eimeria bovis

Campylobacter Biofilms: Potential of Natural Compounds to Disrupt Campylobacter jejuni Transmission

Multifunctional skin dressings synthesized via one‐pot photopolymerization: Advancing wound healing and infection prevention strategies

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