Agnew's general strain theory (GST) [Agnew R (2001) Journal of Research in Crime and Delinquency 38:319-361; Agnew R (2006a) Pressured Into Crime: An Overview of General Strain Theory. LA:Roxbury] has been the focus of considerable academic attention and has become an important criminological theory [Cullen et al. (2006) Taking Stock: The Status ofCriminological Theory. New Brunswick, NJ: Transaction].However, most previous empirical studies have employed Western samples (e.g., US sample) to test this theory, which hinders the generalizability of GST. Although some studies have used Eastern samples to evaluate GST, these studies are only cross-sectional, which makes drawing any causal relationship problematic, and a cross-sectional study cannot uncover the more dynamic relationship between strain, negative emotion, and delinquency. Furthermore, depression has become epidemic around the world [World Health Organization 2001, http://www.who.int/whr/2001/en/whr01_en.pdf) and many previous studies that test GST focus only on anger. This makes depression a crucial element in testing GST. The present study uses longitudinal data (Taiwan Youth Project) and a latent growth model (LGM) to investigate strain, depression, and delinquent acts among adolescents (12-15 years old). The results generally support GST propositions: both strain and depression increase delinquency, and depression mediates the strain-delinquency relationship. Some cultural-specific influences were also discovered.