The Effect of Nephrectomy and Suprarenalectomy in the Rat on Resistance.

Gottesman, J.; Gottesman, Julius

doi:10.3181/00379727-24-3222

Cited by 7 publications

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“…We should like to call attention again to the latent period after suprarenalectomy. As pointed out previously (6), the great drop in resistance does not occur until about the 5th day after the operation. This is illustrated in Table VIII where of 18 rats injected between the 2nd and 4th days, only 5 were killed, whereas of 31 rats injected with the same amounts between the 5th and 8th days, 24 were killed.…”

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confidence: 61%

The Use of Histamine as a Standard Test for Diminished Resistance in Suprarenalectomized Rats

Marmorston-Gottesman¹,

Gottesman²

1928

Journal of Experimental Medicine

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The resistance of suprarenalectomlzed animals to a number of nonspecific poisons is markedly reduced, as has been shown by several independent workers (1-6). These observers employing such poisons as cobra venom, curare, morphine, diphtheria toxin and typhoid vaccine were able to demonstrate a striking difference in resistance between normal and suprarenalectomized rats. In comparing the results obtained in different laboratories with the same poison, considerable differences in the lethal dose appeared to exist. With some of the poisons, as for example, typhoid vaccine, it seemed likely that the difference could be explained by a lack of uniformity of the preparation. Inasmuch as this test may have considerable value in future experimental work, it seemed advisable to secure additional data concerning certain of these poisons in order to find a stable substance having a relatively constant ratio between the lethal dose for suprarenalectomized rats and that for normal rats. This ratio should be at least 1:20. If such a substance could be found, the test might be standardized. In our attempts to standardize this test, we have used, up to the present time, typhoid vaccine, chloral hydrate, sodium cyanide and histamine, and the results obtained may be summarized as follows:Typhoid Vaccine.--Marine and his coworkers (4) have shown that 75 per cent of rats are killed by 0.25 cc. of a standard typhoid vaccine within 8 days after suprarenalectomy. In a recent paper we showed (6) that suprareualectomized rats surviving in good condition are killed by typhoid vaccine in doses of 0.4-1 cc. at the height of susceptibility (5-7 days). On repeating these experiments, it was noted 5o3 on

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confidence: 61%