The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs

Boskabady, Mohammad Hossein; Vahedi, Nassim; Amery, Sediqa; Khakzad, Mohammad Reza

doi:10.1016/j.jep.2011.07.030

Cited by 58 publications

(37 citation statements)

References 40 publications

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“…Th e results of the current study confi rm the previous fi ndings regarding the protective eff ects of NS on renal oxidative damage. Many studies have shown that NS have anti-infl ammatory eff ect in various models (Boskabady et al 2008;Boskabady et al 2011a;Boskabady et al 2011b;Boskabady et al 2011c;Gholamnezhad et al 2015). It has been demonstrated that NS treatment increases CAT, GSH-Px, and SOD activities in the renal ischemia-reperfusion injury (Mousavi 2015).…”

Section: Discussionmentioning

confidence: 99%

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Mohebbati

Hosseini

Haghshenas

et al. 2017

Endocrine Regulations

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Objective. We investigated the eff ects of hydroalcoholic extract of Nigella sativa (NS) on renal tissue oxidative damage associated with propylthiouracil (PTU)-induced hypothyroidism during neonatal and juvenile growth in rats.Methods. Pregnant rats were divided into fi ve groups designated as: 1) control; 2) propylthiouracil (PTU); 3) PTU-NS100; 4) PTU-NS200, and 5) PTU-NS400. All mothers except the control group received 0.005% PTU in their drinking water during lactation. Besides PTU, mothers in groups 3-5 received 100, 200, and 400 mg/kg of NS extract. Aft er lactation period, the off spring continued to receive the same experimental treatment for the fi rst 8 weeks of their life. Ten male off springs of each group were randomly selected, blood samples collected, and the kidney tissues removed.Results. Th e serum thyroxin concentration in PTU group was lower than control group and improved by extract. PTU increased the renal malondialdehyde (MDA), while reduced the total thiols concentrations and catalase (CAT) and superoxide dismutase (SOD) activity compared to control group. Administration of 200 and 400 mg/kg of NS extract decreased MDA level, while it increased the total thiols and 400 mg/kg increased CAT and SOD activity in renal tissues compared to PTU group. Serum creatinine and blood urea nitrogen (BUN) in PTU group was higher than in comparison with the control group. 400 mg/kg decreased creatinine, but both 200 and 400 mg/kg improved BUN concentration compared to PTU group.Conclusion. Th e results of this study demonstrate that the hydroalcoholic extract of NS has a protective eff ect on the renal tissue oxidative damage associated with PTU-induced hypothyroidism during neonatal and juvenile growth in rats.

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Section: Discussionmentioning

confidence: 99%

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Mohebbati

Hosseini

Haghshenas

et al. 2017

Endocrine Regulations

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“…N. sativa has been extensively studied for its biological activities and therapeutic potential and has been shown to possess a wide spectrum of activities such as anti-inflammatory [3], reduced ischemia-reperfusion injury [4], antioxidant [5, 6], antiepileptic [7], antibacterial [8], antihistaminic [9], antinociceptive [10], antidiabetic [11], hepatoprotective [12], and smooth muscle relaxant [9, 13] effects.…”

Section: Introductionmentioning

confidence: 99%

Endothelium-Independent Vasorelaxant Effects of Hydroalcoholic Extract fromNigella sativaSeed in Rat Aorta: The Roles of Ca²⁺and K⁺Channels

Niazmand

Fereidouni

Mahmoudabady

et al. 2014

BioMed Research International

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Objective. The aim of this study was to elucidate the mechanism(s) responsible for the vasorelaxant effect of Nigella sativa (N. sativa). Methods. The activity of different concentrations of N. sativa extract was evaluated on contractile responses of isolated aorta to KCl and phenylephrine (PE). Results. The extract (2–14 mg/mL) induced a concentration dependent relaxation both in endothelium-intact and endothelium-denuded aortic rings precontracted by PE (10−6 M) and KCl (6 × 10−2 M). Extract reduced PE- and KCl-induced contractions in presence of cumulative concentrations of calcium (10−5–10−2 M) significantly. L-NAME and indomethacin had no effect on vasorelaxation effect of extract in PE-induced contraction. Diltiazem and heparin reduced significantly this vasorelaxation at a concentration of 14 mg/mL of extract; however, N. sativa-induced relaxation was not affected by ruthenium red. Tetraethylammonium chloride reduced the extract-induced relaxation in concentrations of 2–6 mg/mL of extract significantly but glibenclamide reduced this relaxative effect in all concentrations of extract. Conclusions. The inhibitory effect of N. sativa seed extract on the contraction induced by PE and KCl was endothelium-independent. This relaxation was mediated mainly through the inhibition of Ca2+ and KATP channels and also intracellular calcium release.

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“…These results indicated a preventive effect of NS only and in combination with dexamethasone on tracheal responsiveness and lung inflammation of sulfur mustard-exposed guinea pigs 181 . Also, NS had an inhibitory effect on histamine (H1) receptors 182 , inhibitory effect on calcium channels 183 and opening effect on potassium channels 69 in guinea pig tracheal chains.…”

Section: Ns and Respiratory Diseasesmentioning

confidence: 64%

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The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs

Cited by 58 publications

References 40 publications

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Endothelium-Independent Vasorelaxant Effects of Hydroalcoholic Extract fromNigella sativaSeed in Rat Aorta: The Roles of Ca²⁺and K⁺Channels

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The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs

Cited by 58 publications

References 40 publications

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats

Endothelium-Independent Vasorelaxant Effects of Hydroalcoholic Extract fromNigella sativaSeed in Rat Aorta: The Roles of Ca2+and K+Channels

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Endothelium-Independent Vasorelaxant Effects of Hydroalcoholic Extract fromNigella sativaSeed in Rat Aorta: The Roles of Ca²⁺and K⁺Channels