The effect of Nigella sativa oil- and wheat germ oil-loaded metal organic frameworks on chronic murine toxoplasmosis

Mohammad, Omnia Sobhi; Naggar, Heba M. El; Abdelmaksoud, Hagar F.; Barakat, Ashraf M.; Abdelhameed, Reda M.; Shehata, Mai Abdel Sameaa

doi:10.1016/j.actatropica.2023.106823

Cited by 7 publications

(4 citation statements)

References 53 publications

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“…In comparison, the PYR+SDZ combination was more effective and showed a significant reduction ( p < 0.05) (71.41%) compared to the chronically infected group. This finding is consistent with the results of Mohammad et al [ 49 ], who found that the brain cyst count in infected mice treated with Cu-BTC MOF was significantly reduced by 24.4%. Moreover, in consensus, Saadatmand et al [ 30 ] revealed that the oral administration of Zn NPs for 14 days at doses of 32.5 and 75 mg/kg/day significantly decreased ( p < 0.001) the mean number and diameter of the brain tissue cysts.…”

Section: Discussionsupporting

confidence: 93%

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Sarhan,

Felemban,

Alelwani

et al. 2024

Pharmaceuticals

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Toxoplasma gondii causes a global parasitic disease. Therapeutic options for eradicating toxoplasmosis are limited. In this study, ZnO and Mg-doped ZnO NPs were prepared, and their structural and morphological chrematistics were investigated. The XRD pattern revealed that Mg-doped ZnO NPs have weak crystallinity and a small crystallite size. FTIR and XPS analyses confirmed the integration of Mg ions into the ZnO framework, producing the high-purity Mg-doped ZnO nanocomposite. TEM micrographs determined the particle size of un-doped ZnO in the range of 29 nm, reduced to 23 nm with Mg2+ replacements. ZnO and Mg-doped ZnO NPs significantly decreased the number of brain cysts (p < 0.05) by 29.30% and 35.08%, respectively, compared to the infected untreated group. The administration of ZnO and Mg-doped ZnO NPs revealed a marked histopathological improvement in the brain, liver, and spleen. Furthermore, ZnO and Mg-doped ZnO NPs reduced P53 expression in the cerebral tissue while inducing CD31 expression, which indicated a protective effect against the infection-induced apoptosis and the restoration of balance between free radicals and antioxidant defense activity. In conclusion, the study proved these nanoparticles have antiparasitic, antiapoptotic, and angiogenetic effects. Being nontoxic compounds, these nanoparticles could be promising adjuvants in treating chronic toxoplasmosis.

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Section: Discussionsupporting

confidence: 93%

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Sarhan,

Felemban,

Alelwani

et al. 2024

Pharmaceuticals

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“…However, the Me49 parasite strain has a high rate of cyst rupture associated with the cellular immune response, which is why the decrease in the number of liver cysts observed with infection has been explained. [39].…”

Section: Discussionmentioning

confidence: 99%

Spiramycin-chitosan Nanoparticles Decline Parasite Burden and Renovate Patent Histopathological Changes in Liver and Lung in Mice Experimentally Infected with Acute Toxoplasmosis

Osama,

El-Dib,

khattab

et al. 2024

Egyptian Journal of Veterinary Sciences

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HE present study was designed to evaluate the use of nanoparticles in improving the antiparasitic effect of Spiramycin, Spiramycin loaded on Carboxymethyl chitosan nanoparticles (CMC Np), ) on experimental toxoplasmosis. Different doses of the drugs under study were assessed using parasitological and histopathological investigations. For this purpose, a total of 38 female Swiss albino mice were divided as follows; Group 1 (5 mice) as a negative control group (non-infected, non-treated group). Group 2 (5 mice) as a positive control group (infected, nontreated group); Group 3: In this group, 28 mice were infected, and treatment started after 10-15 days post-infection for 1 week on a daily basis. The third group was subdivided into four subgroups (7 mice for each), which were treated as follows; subgroup (3a); the infected mice treated with Spiramycin alone in a dose of 100 mg/ kg /day orally, sub group (3b); the infected mice treated with CMC Np orally. Sub group (3c); the infected mice treated with Spiramycin loaded on CMC Np of concentration of 0.35 gm/100 ml H 2 O (low dose-LD) orally. Subgroup (3d); the infected mice treated with Spiramycin loaded on CMC Np of concentration of 0.70 g/ 100 ml H 2 O (High dose-HD) orally. At the end of the experiment, liver and lung were dissected for detection of the parasite burden and the histopathological examination of the tissues was carried out to allocate the histopathological findings in these organs and detection of tissue cysts. Remarkably, a noticeable decrease in parasitic load was stated pooled with renovation of histopathological alterations were prominent with treated groups in association with infected non-treated group.

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“…Another example, reported in 2023, is the therapeutic efficacy of Cu-BTC as a host of two oils that decreases the parasite load of Toxoplasma gondii by 51%, while the empty MOF does not present any antiparasitic effect. 124 Furthermore, it is the beginning of proposals for systems made up of several molecules at the same time such as vancomycin and Fe 3 O 4 housed in MOF-199 and this system is encapsulated by guanidylated β-cyclodextrin. The authors reported a nanosystem called [VAN@Fe 3 O 4 /MOF-199(Cu)]BCD-Gn with MICs of 16 and 128 μg mL −1 , evaluated in S. aureus and E. coli , respectively.…”

Section: Biological Applicationsmentioning

confidence: 99%

Copper(ii)-MOFs for bio-applications

Aguila-Rosas,

Ramos,

Quirino-Barreda

et al. 2023

Chem. Commun.

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The effect of Nigella sativa oil- and wheat germ oil-loaded metal organic frameworks on chronic murine toxoplasmosis

Cited by 7 publications

References 53 publications

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Spiramycin-chitosan Nanoparticles Decline Parasite Burden and Renovate Patent Histopathological Changes in Liver and Lung in Mice Experimentally Infected with Acute Toxoplasmosis

Copper(ii)-MOFs for bio-applications

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